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View article: Metabolic network analysis of Crohn’s disease reveals sex- and age-specific cellular phenotypes
Metabolic network analysis of Crohn’s disease reveals sex- and age-specific cellular phenotypes Open
View article: Cardiac Tamponade as the Initial Presentation of Squamous Cell Carcinoma of the Lung: A Case Report and Literature Review
Cardiac Tamponade as the Initial Presentation of Squamous Cell Carcinoma of the Lung: A Case Report and Literature Review Open
Squamous cell carcinoma (SCC) of the lung, a subtype of nonsmall cell lung cancer (NSCLC), uncommonly causes pericardial effusion. Pericardial effusions occur in 10% to 12% of lung cancer cases but are rarely the initial presentation. We r…
View article: Frequency of spasticity and its association with gender, mechanism, level and type of injury in chronic traumatic SCI patients
Frequency of spasticity and its association with gender, mechanism, level and type of injury in chronic traumatic SCI patients Open
Background: Spinal cord injury is known as a “disconnection syndrome” which leads to loss of ability of the spinal cord to correspond ascending and descending impulses and thus results in loss of motor, sensory and autonomic functions belo…
View article: Decoding the genetic blueprints of neurological disorders: disease mechanisms and breakthrough gene therapies
Decoding the genetic blueprints of neurological disorders: disease mechanisms and breakthrough gene therapies Open
Neurological disorders pose a rapidly growing global health burden, significantly affecting cognitive and motor functions with profound societal repercussions. This comprehensive review probe into the genetic foundations of various neurolo…
View article: Tolebrutinib in Nonrelapsing Secondary Progressive Multiple Sclerosis
Tolebrutinib in Nonrelapsing Secondary Progressive Multiple Sclerosis Open
In participants with nonrelapsing secondary progressive multiple sclerosis, the risk of disability progression was lower among those who received treatment with tolebrutinib than among those who received placebo. (Funded by Sanofi; HERCULE…
View article: Towards Robust Multimodal Representation: A Unified Approach with Adaptive Experts and Alignment
Towards Robust Multimodal Representation: A Unified Approach with Adaptive Experts and Alignment Open
Healthcare relies on multiple types of data, such as medical images, genetic information, and clinical records, to improve diagnosis and treatment. However, missing data is a common challenge due to privacy restrictions, cost, and technica…
View article: Comparative Analysis of Salivary and Serum Inflammatory Mediator Profiles in Patients With Rheumatoid Arthritis and Periodontitis
Comparative Analysis of Salivary and Serum Inflammatory Mediator Profiles in Patients With Rheumatoid Arthritis and Periodontitis Open
Background: Periodontitis (PD) and rheumatoid arthritis (RA) are chronic inflammatory conditions, characterized by dysregulated immune response and excessive production of inflammatory mediators. The oral disease PD is triggered by periodo…
View article: Metabolic Network Analysis of Crohn's Disease Reveals Sex- and Age-Specific Cellular Phenotypes
Metabolic Network Analysis of Crohn's Disease Reveals Sex- and Age-Specific Cellular Phenotypes Open
View article: Author Correction: Early-childhood linear growth faltering in low- and middle-income countries
Author Correction: Early-childhood linear growth faltering in low- and middle-income countries Open
View article: 20438. EFICACIA Y SEGURIDAD DE TOLEBRUTINIB VERSUS PLACEBO EN LA ESCLEROSIS MÚLTIPLE SECUNDARIA PROGRESIVA NO RECURRENTE: RESULTADOS DEL ENSAYO HERCULES DE FASE 3
20438. EFICACIA Y SEGURIDAD DE TOLEBRUTINIB VERSUS PLACEBO EN LA ESCLEROSIS MÚLTIPLE SECUNDARIA PROGRESIVA NO RECURRENTE: RESULTADOS DEL ENSAYO HERCULES DE FASE 3 Open
View article: 20412. EFICACIA Y SEGURIDAD DE TOLEBRUTINIB VS. TERIFLUNOMIDA EN ESCLEROSIS MÚLTIPLE RECURRENTE: RESULTADOS DE LOS ESTUDIOS FASE 3 GEMINI 1 Y 2
20412. EFICACIA Y SEGURIDAD DE TOLEBRUTINIB VS. TERIFLUNOMIDA EN ESCLEROSIS MÚLTIPLE RECURRENTE: RESULTADOS DE LOS ESTUDIOS FASE 3 GEMINI 1 Y 2 Open
View article: 6629 Pure Androgen Secreting Adrenal Adenoma In A Premenopausal Woman
6629 Pure Androgen Secreting Adrenal Adenoma In A Premenopausal Woman Open
Disclosure: S. Syed: None. Background: Pure androgen secreting adrenal adenomas are extremely rare; most of the reported cases occur in post-menopausal women, with significant virilization of acute onset and are usually malignant. Here we …
View article: ERDS: Optimizing Domains Using Observation-Based Extremity
ERDS: Optimizing Domains Using Observation-Based Extremity Open
View article: Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children
Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children Open
This scoring system involving 5 histologic parameters demonstrates very high discrimination between EED and normal biopsies, indicating that this scoring system can be applied with confidence to studies of intestinal biopsies in EED.
View article: Machine-learning-based integrative –‘omics analyses reveal immunologic and metabolic dysregulation in environmental enteric dysfunction
Machine-learning-based integrative –‘omics analyses reveal immunologic and metabolic dysregulation in environmental enteric dysfunction Open
View article: A shared group of bacterial taxa in the duodenal microbiota of undernourished Pakistani children with environmental enteric dysfunction
A shared group of bacterial taxa in the duodenal microbiota of undernourished Pakistani children with environmental enteric dysfunction Open
Environmental enteric dysfunction (EED) is a subclinical syndrome of altered small intestinal function postulated to be an important contributor to childhood undernutrition. The role of small intestinal bacterial communities in the pathoph…
View article: Challenges in IBD Research 2024: Precision Medicine
Challenges in IBD Research 2024: Precision Medicine Open
Precision medicine is part of 5 focus areas of the Challenges in IBD Research 2024 research document, which also includes preclinical human IBD mechanisms, environmental triggers, novel technologies, and pragmatic clinical research. Buildi…
View article: Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multicountry analysis
Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multicountry analysis Open
View article: Diffusion and Multi-Domain Adaptation Methods for Eosinophil Segmentation
Diffusion and Multi-Domain Adaptation Methods for Eosinophil Segmentation Open
Eosinophilic Esophagitis (EoE) represents a challenging condition for medical providers today. The cause is currently unknown, the impact on a patient's daily life is significant, and it is increasing in prevalence. Traditional approaches …
View article: Diffusion and Multi-Domain Adaptation Methods for Eosinophil Segmentation
Diffusion and Multi-Domain Adaptation Methods for Eosinophil Segmentation Open
Eosinophilic Esophagitis (EoE) represents a challenging condition for medical providers today. The cause is currently unknown, the impact on a patient's daily life is significant, and it is increasing in prevalence. Traditional approaches …
View article: Prediction of response to anti-TNFα using integrative computational approaches in Crohn’s disease—Needle in a haystack or a promising biomarker?
Prediction of response to anti-TNFα using integrative computational approaches in Crohn’s disease—Needle in a haystack or a promising biomarker? Open
In the January issue of Cell Reports Medicine, Gerassy-Vainberg et al.1 demonstrate the utility of integrative methods to reveal molecular mechanisms associated with anti-tumor necrosis factor-alpha therapy response in patients …
View article: Inspiring diverse researchers in Virginia: Cultivating research excellence through a career-building program
Inspiring diverse researchers in Virginia: Cultivating research excellence through a career-building program Open
Historically underrepresented groups in biomedical research have continued to experience low representation despite shifting demographics. Diversity fosters inclusive, higher quality, and innovative team science. One avenue for diversifyin…
View article: Inspiring Diverse Researchers in Virginia: Cultivating Research Excellence Through a Career Building Program
Inspiring Diverse Researchers in Virginia: Cultivating Research Excellence Through a Career Building Program Open
Historically underrepresented groups in biomedical research have continued to experience low representation despite shifting demographics. Diversity fosters inclusive, higher quality, and innovative team science. One avenue for diversifyin…
View article: Author Correction: Early-childhood linear growth faltering in low- and middle-income countries
Author Correction: Early-childhood linear growth faltering in low- and middle-income countries Open
View article: Author Correction: Child wasting and concurrent stunting in low- and middle-income countries
Author Correction: Child wasting and concurrent stunting in low- and middle-income countries Open
View article: Uncertainty Quantification for Eosinophil Segmentation
Uncertainty Quantification for Eosinophil Segmentation Open
Eosinophilic Esophagitis (EoE) is an allergic condition increasing in prevalence. To diagnose EoE, pathologists must find 15 or more eosinophils within a single high-power field (400X magnification). Determining whether or not a patient ha…
View article: Uncertainty Quantification for Eosinophil Segmentation
Uncertainty Quantification for Eosinophil Segmentation Open
Eosinophilic Esophagitis (EoE) is an allergic condition increasing in prevalence. To diagnose EoE, pathologists must find 15 or more eosinophils within a single high-power field (400X magnification). Determining whether or not a patient ha…
View article: Early-childhood linear growth faltering in low- and middle-income countries
Early-childhood linear growth faltering in low- and middle-income countries Open
Globally, 149 million children under 5 years of age are estimated to be stunted (length more than 2 standard deviations below international growth standards) 1,2 . Stunting, a form of linear growth faltering, increases the risk of illness,…
View article: Child wasting and concurrent stunting in low- and middle-income countries
Child wasting and concurrent stunting in low- and middle-income countries Open
View article: The intersection of video capsule endoscopy and artificial intelligence: addressing unique challenges using machine learning
The intersection of video capsule endoscopy and artificial intelligence: addressing unique challenges using machine learning Open
Introduction: Technical burdens and time-intensive review processes limit the practical utility of video capsule endoscopy (VCE). Artificial intelligence (AI) is poised to address these limitations, but the intersection of AI and VCE revea…