Sohan L. Manocha
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View article: Design, Synthesis and Evaluation of New Inhibitors of DNA G4 Unfolding by DHX36 helicase
Design, Synthesis and Evaluation of New Inhibitors of DNA G4 Unfolding by DHX36 helicase Open
The quadruplex DNA structures formed by the guanine-rich sequences (G4) present in promoter regions of oncogenes, like c-MYC, are emerging as selective anticancer drug targets, with two molecules in phase I clinical trials. G4s are dynamic…