Soheila Rezaei Adariani
YOU?
Author Swipe
View article: Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders
Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders Open
Terpenoid alkaloids are derived from the fusion of structurally diverse terpenoid‐ and alkaloid moieties. The biologically relevant chemical space defined by this unique natural product (NP) class may be explored beyond the limitations of …
View article: Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders
Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders Open
Terpenoid alkaloids are derived from the fusion of structurally diverse terpenoid‐ and alkaloid moieties. The biologically relevant chemical space defined by this unique natural product (NP) class may be explored beyond the limitations of …
View article: Detection of a Mitochondrial Fragmentation and Integrated Stress Response Using the Cell Painting Assay
Detection of a Mitochondrial Fragmentation and Integrated Stress Response Using the Cell Painting Assay Open
Mitochondria are cellular powerhouses and are crucial for cell function. However, they are vulnerable to internal and external perturbagens that may impair mitochondrial function and eventually lead to cell death. In particular, small mole…
View article: Illuminating Dark Chemical Matter Using the Cell Painting Assay
Illuminating Dark Chemical Matter Using the Cell Painting Assay Open
Screening for small-molecule modulators of disease-relevant targets and phenotypes is the first step on the way to new drugs. Large compound libraries have been synthesized by academia and, particularly, pharmaceutical companies to meet th…
View article: Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype
Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype Open
Targeted proteasomal and autophagic protein degradation, often employing bifunctional modalities, is a new paradigm for modulation of protein function. In an attempt to explore protein degradation by means of autophagy we combine arylidene…
View article: Detection of a Mitochondrial Stress Phenotype using the Cell Painting Assay
Detection of a Mitochondrial Stress Phenotype using the Cell Painting Assay Open
Mitochondria are cellular powerhouses and crucial for cell function. However, these organelles are vulnerable to internal and external perturbagens that may impair mitochondrial function and eventually lead to cell death. In particular, sm…
View article: Illuminating Dark Chemical Matter using the Cell Painting Assay
Illuminating Dark Chemical Matter using the Cell Painting Assay Open
The identification of bioactive small molecules is at the heart of chemical biology and medicinal research. The screening for modulators of disease-relevant targets and phenotypes is the first step on the way to new drugs. Therefore, large…
View article: Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype
Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype Open
Targeted proteasomal and autophagic protein degradation, often employing bifunctional modalities, is a new paradigm for modulation of protein function. In an attempt to explore protein degradation by means of autophagy we combined aryliden…
View article: Physical Interaction between Embryonic Stem Cell-Expressed Ras (ERas) and Arginase-1 in Quiescent Hepatic Stellate Cells
Physical Interaction between Embryonic Stem Cell-Expressed Ras (ERas) and Arginase-1 in Quiescent Hepatic Stellate Cells Open
Embryonic stem cell-expressed Ras (ERas) is an atypical constitutively active member of the Ras family and controls distinct signaling pathways, which are critical, for instance, for the maintenance of quiescent hepatic stellate cells (HSC…
View article: Identifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95
Identifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95 Open
Previous studies of the N-terminal PDZ tandem from PSD-95 produced divergent models and failed to identify interdomain contacts stabilizing the structure. We used ensemble and single-molecule FRET along with replica-exchange molecular dyna…
View article: Precision and accuracy of single-molecule FRET measurements - a worldwide benchmark study
Precision and accuracy of single-molecule FRET measurements - a worldwide benchmark study Open
Single-molecule Förster resonance energy transfer (smFRET) is increasingly being used to determine distances, structures, and dynamics of biomolecules in vitro and in vivo. However, generalized protocols and FRET standards ensuring both th…
View article: High Precision FRET at Single-molecule Level for Biomolecule Structure Determination
High Precision FRET at Single-molecule Level for Biomolecule Structure Determination Open
A protocol on how to perform high-precision interdye distance measurements using Förster resonance energy transfer (FRET) at the single-molecule level in multiparameter fluorescence detection (MFD) mode is presented here. MFD maximizes the…
View article: Conformational Selection and Submillisecond Dynamics of the Ligand-binding Domain of the N-Methyl-d-aspartate Receptor
Conformational Selection and Submillisecond Dynamics of the Ligand-binding Domain of the N-Methyl-d-aspartate Receptor Open
The N-methyl-d-aspartate (NMDA) receptors are heteromeric non-selective cation channels that require the binding of glycine and glutamate for gating. Based on crystal structures, the mechanism of partial agonism at the glycine-binding site…
View article: Studying the Conformational Landscape of Biomolecules Using Single Molecule Fluorescence Spectroscopy
Studying the Conformational Landscape of Biomolecules Using Single Molecule Fluorescence Spectroscopy Open
Proteins have many important functions in living system. They are produced from ribosomes as unstructured polypeptide chains of amino acids and then either fold by themselves or with the help of chaperones into their functional, three dime…