Soichiro Ide
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View article: Vibration control of a large slewing crane by combining a plant model considering boom deflection with an inverse dynamics based on a rigid boom model
Vibration control of a large slewing crane by combining a plant model considering boom deflection with an inverse dynamics based on a rigid boom model Open
Slewing cranes are useful for the handling work of heavy objects, such as in construction works. However, the load sway of the crane is a major problem, because it reduces safety and workability. Especially in large slewing cranes, the def…
View article: 239. THE INHIBITORY EFFECT OF IFENPRODIL ON NICOTINE-INDUCED ADDICTIVE BEHAVIORS
239. THE INHIBITORY EFFECT OF IFENPRODIL ON NICOTINE-INDUCED ADDICTIVE BEHAVIORS Open
Background Nicotine addiction remains a significant global health issue due to its high relapse rates and the limited success of current treatment options. This highlights the need for new therapeutic strategies that target novel mechanism…
View article: 113. SEX-SPECIFIC EFFECTS OF REPEATED KETAMINE EXPOSURE ON LOCOMOTOR ACTIVITY IN MICE: INFLUENCE OF SOCIAL AND ISOLATED HOUSING CONDITIONS
113. SEX-SPECIFIC EFFECTS OF REPEATED KETAMINE EXPOSURE ON LOCOMOTOR ACTIVITY IN MICE: INFLUENCE OF SOCIAL AND ISOLATED HOUSING CONDITIONS Open
Background Recent evidence indicates that ketamine, an NMDA receptor antagonist, has rapid antidepressant effects in treatment-resistant patients. However, the club drug ketamine is widely abused, raising concerns about long-term treatment…
View article: Structural differences between human and mouse neurons and their implementation in generative AIs
Structural differences between human and mouse neurons and their implementation in generative AIs Open
View article: Effects of NMDA receptor antagonists on working memory and gamma oscillations, and the mediating role of the GluN2D subunit
Effects of NMDA receptor antagonists on working memory and gamma oscillations, and the mediating role of the GluN2D subunit Open
Working memory relies on synchronised network oscillations involving complex interplay between pyramidal cells and GABAergic interneurons. NMDA receptor (NMDAR) antagonists influence both network oscillations and working memory, but the re…
View article: SEX DIFFERENCES IN THE REDUCTION OF HOPELESSNESS IN Μ OPIOID RECEPTOR DEFICIENT MICE BY ADDITIVE EFFECTS OF Δ OPIOID RECEPTOR AGONISTS
SEX DIFFERENCES IN THE REDUCTION OF HOPELESSNESS IN Μ OPIOID RECEPTOR DEFICIENT MICE BY ADDITIVE EFFECTS OF Δ OPIOID RECEPTOR AGONISTS Open
Previous pharmacological data have shown the possible existence of functional interactions between μ, κ, and δ opioid receptors in pain and mood disorders. We have reported previously μ opioid receptor knockout (MOP-KO) mice showed a reduc…
View article: ANALYSIS OF DOPAMINE TRANSPORTER-EXPRESSING NEURON-SPECIFIC TYROSINE HYDROXYLASE KNOCKOUT MICE
ANALYSIS OF DOPAMINE TRANSPORTER-EXPRESSING NEURON-SPECIFIC TYROSINE HYDROXYLASE KNOCKOUT MICE Open
Background Tyrosine hydroxylase (TH), an enzyme synthesizing L-dopa from tyrosine, expresses dopaminergic and noradrenergic neurons. Dopamine transporter (DAT) expresses specifically in synaptic terminals of dopaminergic neurons and re-upt…
View article: MODULATION OF THE DOPAMINERGIC NEUROTRANSMISSION BY CONTROLLING THE ACTIVITY OF TYROSINE HYDROXYLASE
MODULATION OF THE DOPAMINERGIC NEUROTRANSMISSION BY CONTROLLING THE ACTIVITY OF TYROSINE HYDROXYLASE Open
Background Dopaminergic neurotransmission is involved in several important issues for determination of our behaviour including motivation, decision-making, and motor-control. Therefore, its dysfunction is deeply involved in movement disord…
View article: Differential effects of NMDAR antagonists on working memory and gamma oscillations, and the mediating role of the GluN2D subunit
Differential effects of NMDAR antagonists on working memory and gamma oscillations, and the mediating role of the GluN2D subunit Open
Working memory relies on synchronised network oscillations involving complex interplay between pyramidal cells and GABAergic interneurons. NMDA receptor (NMDAR) antagonists influence both network oscillations and working memory, but the re…
View article: Inhibitory effects of the selective μ‐opioid receptor antagonist <scp>UD</scp>‐030 on methamphetamine‐induced conditioned place preference
Inhibitory effects of the selective μ‐opioid receptor antagonist <span>UD</span>‐030 on methamphetamine‐induced conditioned place preference Open
Although methamphetamine (METH) and other addictive substance use disorders are a major social problem worldwide, appropriate pharmacotherapies have not yet been discovered. Subtype‐nonselective opioid receptor antagonists, such as naltrex…
View article: Update of the FANTOM web resource: enhancement for studying noncoding genomes
Update of the FANTOM web resource: enhancement for studying noncoding genomes Open
The FANTOM web resource (https://fantom.gsc.riken.jp/) has been a unique resource for studying mammalian genomes, which is built on the research activities conducted in the international collaborative project FANTOM (Functional ANnoTation …
View article: Murine AI excels at cats and cheese: Structural differences between human and mouse neurons and their implementation in generative AIs
Murine AI excels at cats and cheese: Structural differences between human and mouse neurons and their implementation in generative AIs Open
Mouse and human brains have different functions that depend on their neuronal networks. In this study, we analyzed nanometer-scale three-dimensional structures of brain tissues of the mouse medial prefrontal cortex and compared them with s…
View article: Mouse Model of Parkinson’s Disease with Bilateral Dorsal Striatum Lesion with 6-Hydroxydopamine Exhibits Cognitive Apathy-like Behavior
Mouse Model of Parkinson’s Disease with Bilateral Dorsal Striatum Lesion with 6-Hydroxydopamine Exhibits Cognitive Apathy-like Behavior Open
Among the symptoms of Parkinson’s disease (PD), apathy comprises a set of behavioral, affective, and cognitive features that can be classified into several subtypes. However, the pathophysiology and brain regions that are involved in these…
View article: Loss of the sustained antidepressant-like effect of (2R,6R)-hydroxynorketamine in NMDA receptor GluN2D subunit knockout mice
Loss of the sustained antidepressant-like effect of (2R,6R)-hydroxynorketamine in NMDA receptor GluN2D subunit knockout mice Open
Ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, has attracted attention for its acute and sustained antidepressant effects in patients with depression. Hydroxynorketamine (HNK), a metabolite of ketamine, exerts antidepressant…
View article: Effects of the novel selective κ-opioid receptor agonist NP-5497-KA on morphine-induced reward-related behaviors
Effects of the novel selective κ-opioid receptor agonist NP-5497-KA on morphine-induced reward-related behaviors Open
Opioid addiction and the opioid overdose epidemic are becoming more serious, and the development of therapeutic agents is essential for the pharmacological treatment of substance use disorders. The κ-opioid receptor (KOP) is a member of th…
View article: Understanding the role of the <scp>NMDA</scp> receptor subunit, <scp>GluN2D</scp> , in mediating <scp>NMDA</scp> receptor antagonist‐induced behavioral disruptions in male and female mice
Understanding the role of the <span>NMDA</span> receptor subunit, <span>GluN2D</span> , in mediating <span>NMDA</span> receptor antagonist‐induced behavioral disruptions in male and female mice Open
Noncompetitive NMDA receptor (NMDAR) antagonists like phencyclidine (PCP) and ketamine cause psychosis‐like symptoms in healthy humans, exacerbate schizophrenia symptoms in people with the disorder, and disrupt a range of schizophrenia‐rel…
View article: Systematic Reduction of Gray Matter Volume in Anorexia Nervosa, but Increase With Clinical Symptoms in the Prefrontal and Posterior Insular Cortices: A Multicenter Neuroimaging Study
Systematic Reduction of Gray Matter Volume in Anorexia Nervosa, but Increase With Clinical Symptoms in the Prefrontal and Posterior Insular Cortices: A Multicenter Neuroimaging Study Open
Although brain morphological abnormalities have been reported in anorexia nervosa (AN), the reliability and reproducibility of previous studies were limited due to insufficient sample sizes, which prevented exploratory analysis of the whol…
View article: Inhibitory Effects of a Novel μ-Opioid Receptor Nonpeptide Antagonist, UD-030, on Morphine-Induced Conditioned Place Preference
Inhibitory Effects of a Novel μ-Opioid Receptor Nonpeptide Antagonist, UD-030, on Morphine-Induced Conditioned Place Preference Open
Although opioids are widely used to treat moderate to severe pain, opioid addiction and the opioid overdose epidemic are becoming more serious. Although opioid receptor antagonists/partial agonists, such as naltrexone and buprenorphine, ha…
View article: Inhibitory effects of the novel μ-opioid receptor non-peptide antagonist, UD-030, on the morphine-conditioned place preference
Inhibitory effects of the novel μ-opioid receptor non-peptide antagonist, UD-030, on the morphine-conditioned place preference Open
Although opioids are widely used to treat moderate to severe pain, opioid addiction and the opioid overdose epidemic are becoming more serious. Although opioid receptor antagonists/partial agonists, such as naltrexone and buprenorphine, ha…
View article: Role for μ-opioid receptor in antidepressant effects of δ-opioid receptor agonist KNT-127
Role for μ-opioid receptor in antidepressant effects of δ-opioid receptor agonist KNT-127 Open
Previous pharmacological data have shown the possible existence of functional interactions between μ- (MOP), κ- (KOP), and δ-opioid receptors (DOP) in pain and mood disorders. We previously reported that MOP knockout (KO) mice exhibit a lo…
View article: GIRK Channels as Candidate Targets for the Treatment of Substance Use Disorders
GIRK Channels as Candidate Targets for the Treatment of Substance Use Disorders Open
Substance use disorders (SUDs) are chronic, lifelong disorders that have serious consequences. Repeated substance use alters brain function. G-protein-activated inwardly rectifying potassium (GIRK) channels are expressed widely in the brai…
View article: Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors
Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors Open
Inhibition of histone deacetylase 6 (HDAC6) in the brain is a highly attractive therapeutic target for the treatment of neurodegenerative diseases. The low blood-brain barrier permeability of most known HDAC6 inhibitors, however, prevents …
View article: Interaction between social behavior and paternal age in offspring of the same paternal mice
Interaction between social behavior and paternal age in offspring of the same paternal mice Open
Aim Previous studies reported that advanced paternal age (APA) may increase the risk of autism spectrum disorder (ASD) in offspring. However, effects of APA on behaviors have not been investigated in offspring of the same paternal mice. Th…
View article: Caenorhabditis Elegans Exhibits Morphine Addiction-like Behavior via the Opioid-like Receptor NPR-17
Caenorhabditis Elegans Exhibits Morphine Addiction-like Behavior via the Opioid-like Receptor NPR-17 Open
Addiction has become a profound societal problem worldwide, and few effective treatments are available. The nematode Caenorhabditis elegans ( C. elegans ) is an excellent invertebrate model to study neurobiological disease states. C. elega…
View article: Loss of the sustained antidepressant effect of (<i>2R,6R</i>)-hydroxynorketamine in NMDA receptor GluN2D subunit knockout mice
Loss of the sustained antidepressant effect of (<i>2R,6R</i>)-hydroxynorketamine in NMDA receptor GluN2D subunit knockout mice Open
Background: The NMDA receptor antagonist ketamine exhibits acute and sustained antidepressant effects and is rapidly metabolized. We have reported that GluN2D plays an important role in the sustained antidepressant effect of (R)-ketamine, …
View article: Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice
Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice Open
View article: Future direction of addiction research—An expert questionnaire survey in Japan
Future direction of addiction research—An expert questionnaire survey in Japan Open
Addiction has become a major worldwide medical, public health, and social problem. Because the prevalence of addiction varies widely geographically, due to differences in ethnicity, culture, education, social environment, and regulation, e…
View article: Adolescent Problem Gaming and Loot Box Purchasing in Video Games: Cross-sectional Observational Study Using Population-Based Cohort Data
Adolescent Problem Gaming and Loot Box Purchasing in Video Games: Cross-sectional Observational Study Using Population-Based Cohort Data Open
Background Video game loot boxes, which can typically be purchased by players or are given as reward, contain random virtual items, or loot, ranging from simple customization options for a player's avatar or character, to game-changing equ…
View article: Required Research Activities to Overcome Addiction Problems in Japan
Required Research Activities to Overcome Addiction Problems in Japan Open
Background: The term “addiction” encompasses both substance dependence and behavioral addiction and is associated with major societal problems. Measures to combat addiction are currently insufficient in Japan, and further research on addic…
View article: Intracranial self-stimulation method in addiction research
Intracranial self-stimulation method in addiction research Open
In recent years, various problems of addiction have become prevalent in the world, and the situation has become more serious. Addiction is a condition that arises when the ingestion of an addictive substance or the performance of a particu…