Soichiro Kimura
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View article: Whole-genome sequencing analysis of molecular epidemiology and silent transmissions causing meticillin-resistant Staphylococcus aureus bloodstream infections in a university hospital
Whole-genome sequencing analysis of molecular epidemiology and silent transmissions causing meticillin-resistant Staphylococcus aureus bloodstream infections in a university hospital Open
Routine monitoring of MRSA by whole-genome analysis is effective not only for gaining knowledge regarding molecular epidemiology, but also for detecting silent nosocomial transmission.
View article: Jagged-1 Reduces Th2 Inflammation and Memory Cell Expansion in Allergic Airway Disease
Jagged-1 Reduces Th2 Inflammation and Memory Cell Expansion in Allergic Airway Disease Open
Notch ligands present during interactions between T cells and dendritic cells (DCs) dictate cell phenotype through a myriad of effects including the induction of T cell regulation, survival, and cytokine response. The presence of Notch lig…
View article: Apoptosis Inhibitor of Macrophages Contributes to the Chronicity of <i>Mycobacterium avium</i> Infection by Promoting Foamy Macrophage Formation
Apoptosis Inhibitor of Macrophages Contributes to the Chronicity of <i>Mycobacterium avium</i> Infection by Promoting Foamy Macrophage Formation Open
In Mycobacterium avium infections, macrophages play a critical role in the host defense response. Apoptosis inhibitor of macrophage (AIM), also known as CD5L, may represent a novel supportive therapy against various diseases, including met…
View article: Protective effect of teriparatide against vancomycin-induced cytotoxicity in osteoblasts
Protective effect of teriparatide against vancomycin-induced cytotoxicity in osteoblasts Open
Vancomycin-induced cytotoxicity in osteoblasts could be inhibited by administering teriparatide concomitantly with vancomycin.
View article: Increased Incidence and Plasma-Biofilm Formation Ability of SCCmec Type IV Methicillin-Resistant Staphylococcus aureus (MRSA) Isolated From Patients With Bacteremia
Increased Incidence and Plasma-Biofilm Formation Ability of SCCmec Type IV Methicillin-Resistant Staphylococcus aureus (MRSA) Isolated From Patients With Bacteremia Open
In Japan, Staphylococcal cassette chromosome mec (SCC mec ) type IV methicillin-resistant Staphylococcus aureus (MRSA) is an increasingly prominent cause of bacteremia, but the virulence of most of these strains is unclear. We aimed to inv…
View article: Traditional Japanese Herbal Medicine Hochu-Ekki-to Promotes Pneumococcal Colonization Clearance via Macrophage Activation and Interleukin 17A Production in Mice
Traditional Japanese Herbal Medicine Hochu-Ekki-to Promotes Pneumococcal Colonization Clearance via Macrophage Activation and Interleukin 17A Production in Mice Open
Streptococcus pneumoniae may colonize the nasopharynx, and as pneumococcal colonization causes invasive diseases and the subsequent transmission, reducing bacterial burden in the nasal cavity is critical. Hochu-ekki-to (TJ-41) is a traditi…
View article: Tissue Damage Caused by Impaired Phagocytosis of Dead Cells: A Previously Unrecognized Adverse Effect Contributing to the Pathogenesis of γδ T Cells in <i>Legionella</i> Pneumonia
Tissue Damage Caused by Impaired Phagocytosis of Dead Cells: A Previously Unrecognized Adverse Effect Contributing to the Pathogenesis of γδ T Cells in <i>Legionella</i> Pneumonia Open
IL-17 plays a critical role in the immunological control of various infectious diseases; its function has been investigated in the removal of both extracellular and intracellular bacteria. Our group previously revealed the importance of IL…
View article: Does Vitamin D3 Prevent the Inhibitory Effect of Vancomycin on Osteoblasts?
Does Vitamin D3 Prevent the Inhibitory Effect of Vancomycin on Osteoblasts? Open
Background The utility of vancomycin powder to prevent surgical site infection, mainly in spinal surgery, has been widely examined, and the local administration of vancomycin powder to wounds has been reported to be effective in preventing…
View article: Jagged-1 regulates <i>Foxp3</i> expression and cytokine production in CD4<sup>+</sup> T cells
Jagged-1 regulates <i>Foxp3</i> expression and cytokine production in CD4<sup>+</sup> T cells Open
Notch ligands are present during the interactions between T cells and dendritic cells (DC) and induce a myriad of effects that facilitate the activation of T cells, including the induction of T cell regulation, survival, and cytokine produ…
View article: JunB plays a crucial role in development of regulatory T cells by promoting IL-2 signaling
JunB plays a crucial role in development of regulatory T cells by promoting IL-2 signaling Open
The AP-1 transcription factor JunB plays crucial roles in multiple biological processes, including placental formation and bone homeostasis. We recently reported that JunB is essential for development of Th17 cells, and thus Junb-deficient…
View article: Evidence of latent molecular diversity determining the virulence of community‐associated MRSA USA300 clones in mice
Evidence of latent molecular diversity determining the virulence of community‐associated MRSA USA300 clones in mice Open
Introduction The USA300 clone of community‐associated MRSA is reported to be hypervirulent and epidemic in the United States. This clone causes a variety of diseases from lethal pneumonia to mild skin infections. We hypothesized that evolu…
View article: Systemic Expression of Notch Ligand Delta-Like 4 during Mycobacterial Infection Alters the T Cell Immune Response
Systemic Expression of Notch Ligand Delta-Like 4 during Mycobacterial Infection Alters the T Cell Immune Response Open
The Notch ligand delta-like 4 (DLL4) is known to fine-tune the CD4+ T cell cytokine response. DLL4 is expressed on the surface of antigen-presenting cells (APCs) in a MyD88-dependent manner. We found that DLL4 expression was upregulated on…
View article: Application of Microneedles to Skin Induces Activation of Epidermal Langerhans Cells and Dermal Dendritic Cells in Mice
Application of Microneedles to Skin Induces Activation of Epidermal Langerhans Cells and Dermal Dendritic Cells in Mice Open
An adequate immune response to percutaneous vaccine application is generated by delivery of sufficient amounts of antigen to skin and by administration of toxin adjuvants or invasive skin abrasion that leads to an adjuvant effect. Micronee…