Sok Ching Cheong
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View article: Supplementary Data from Mutated HRAS Activates YAP1–AXL Signaling to Drive Metastasis of Head and Neck Cancer
Supplementary Data from Mutated HRAS Activates YAP1–AXL Signaling to Drive Metastasis of Head and Neck Cancer Open
Supplementary Materials and Methods
View article: Supplementary Figure from Mutated HRAS Activates YAP1–AXL Signaling to Drive Metastasis of Head and Neck Cancer
Supplementary Figure from Mutated HRAS Activates YAP1–AXL Signaling to Drive Metastasis of Head and Neck Cancer Open
Supplementary Figures S1 to S6 with figure legends
View article: MyGESig: a population-specific gene signature improves survival prediction in Malaysian breast cancer patients
MyGESig: a population-specific gene signature improves survival prediction in Malaysian breast cancer patients Open
Accurate prognostic models are essential for guiding treatment decisions and improving patient outcomes in breast cancer. To achieve this, population-specific models are needed to account for genetic, clinical, and pathological differences…
View article: Cancer vaccine overcomes immune evasion of nasopharyngeal carcinoma by restoring MHC-I through transcriptional regulation of NLRC5
Cancer vaccine overcomes immune evasion of nasopharyngeal carcinoma by restoring MHC-I through transcriptional regulation of NLRC5 Open
Background Nasopharyngeal carcinoma (NPC) is considered an immune-hot tumour. However, 30–80% of cases exhibit downregulation of antigen processing and presentation machinery (APM), enabling the evasion of host immunosurveillance. While ca…
View article: FIGURE 5 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
FIGURE 5 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
NPC268 is characterized by a high number of SVs and showed enrichment in immune-related gene expression. A, Circos plot showing an overview of genomic aberrations in NPC268 as revealed by WGS analysis. From outer to inner rings: (1)…
View article: FIGURE 7 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
FIGURE 7 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
Drug sensitivity profile of NPC268 and other NPC cell lines show preferential sensitivity of NPC268 toward BCL2 inhibitors. A, High-throughput screening on 339 drugs was performed on NPC268 and other NPC cell lines (EBV-negative: NP…
View article: FIGURE 2 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
FIGURE 2 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
EBV is preserved in NPC268 and can be induced into lytic infection. A, EBER staining was positive in early and late passage of NPC268, but LMP1 and BZLF1 protein expressions were lost in the late passage. Scale bar: 100 µm. B,
View article: FIGURE 1 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
FIGURE 1 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
Establishment of a new EBV-positive NPC cell line, NPC268 from a non-keratinizing differentiated NPC primary tumor. A, H&E staining revealed NPC268 tumor as the non-keratinizing, differentiated NPC subtype. Scale bar: 100 µm. B,<…
View article: FIGURE 4 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
FIGURE 4 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
NPC268 is highly tumorigenic and demonstrate lytic activity in vivo. A,In vivo growth curve of NPC268 mouse xenografts (early passage xenograft, E-X-1, E-X-2, E-X-3 and late passage xenograft, L-X-1, L-X-2, L-X-3). …
View article: Supplementary Figure 1 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
Supplementary Figure 1 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
Karyotype analysis of NPC268 and confirmation of epithelial origin.
View article: Data from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
Data from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
Nasopharyngeal carcinoma (NPC), a cancer that is etiologically associated with the Epstein-Barr virus (EBV), is endemic in Southern China and Southeast Asia. The scarcity of representative NPC cell lines owing to the frequent loss of EBV e…
View article: FIGURE 6 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
FIGURE 6 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
NPC268 resembles the HypoNPC subtype and showed enrichment in immune-related gene expression. A, WGBS analysis revealed the methylation level of NPC268, resembling that of HypoNPC subtype. Heat map shows the global methylation level…
View article: FIGURE 3 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma
FIGURE 3 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma Open
EBV genome analysis of NPC268 reveals resemblance with those commonly found in NPC from endemic regions. A, PCA of the 213 EBV genomes was performed. PC2 was plotted against PC1, each dot represents a previously published EBV genome…
View article: Supplementary Table 5 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Supplementary Table 5 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis Open
List of 142 significant positively correlated drug-gene pairs
View article: Supplementary Table 2 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Supplementary Table 2 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis Open
List of sgRNAs and their sequences
View article: Supplementary Table 3 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Supplementary Table 3 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis Open
List of antibodies
View article: Supplementary Figure 3 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Supplementary Figure 3 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis Open
Correlation of AZD5582 sensitivity with OSCC essential genes.
View article: Supplementary Table 1 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Supplementary Table 1 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis Open
List of compounds screened, their putative targets and supplier info.
View article: Supplementary Figure 2 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Supplementary Figure 2 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis Open
A subset of OSCCs is vulnerable to AZD5582 and other IAP inhibitors.
View article: Supplementary Table 6 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Supplementary Table 6 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis Open
Differentially expressed genes (DEGs) in AZD5582-treated cells compared to control
View article: Supplementary Table 4 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Supplementary Table 4 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis Open
ln IC50 data of 339 compounds in 21 OSCC cell lines
View article: Supplementary Figure 4 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Supplementary Figure 4 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis Open
Investigation of gene expression changes associated with AZD5582.
View article: Supplementary Figure 5 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Supplementary Figure 5 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis Open
Necroptosis is activated in the absent of CASP8 upon AZD5582 treatment as shown by induction of p-MLKL.
View article: Supplementary Figure 6 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Supplementary Figure 6 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis Open
All uncropped western blot images
View article: Supplementary Figure 1 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Supplementary Figure 1 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis Open
PIK3CA-dependent OSCC showed higher sensitivity towards PI3K inhibitors.
View article: Interferon‐Inducible ADAR1 p150 Is Essential for the Survival of Oral Squamous Cell Carcinoma
Interferon‐Inducible ADAR1 p150 Is Essential for the Survival of Oral Squamous Cell Carcinoma Open
We identified ADAR1 as one of the top essential genes for oral squamous cell carcinoma (OSCC) survival from our genome‐wide CRISPR/Cas9 screen in OSCC cell lines. In this study, we confirm that ADAR1‐knockout (KO) inhibits cell viability a…
View article: Pembrolizumab (MK-3475) plus platinum and gemcitabine as first-line treatment of recurrent/metastatic head and neck squamous cell carcinoma (PIPER): a phase 2, multicentre, single-arm protocol study in Malaysia
Pembrolizumab (MK-3475) plus platinum and gemcitabine as first-line treatment of recurrent/metastatic head and neck squamous cell carcinoma (PIPER): a phase 2, multicentre, single-arm protocol study in Malaysia Open
Introduction Treatment combination of pembrolizumab plus platinum and 5-fluorouracil (PF) has increased the survival of recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). The combination of platinum and gemcitabin…
View article: Supplementary Figure 2 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Supplementary Figure 2 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis Open
A subset of OSCCs is vulnerable to AZD5582 and other IAP inhibitors.
View article: Figure 3 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Figure 3 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis Open
AZD5582 sensitivity is correlated with dependency on fitness genes from the NF-κB pathway. A, The STRING protein–protein interaction network of AZD5582 targets (BIRC2, BIRC3, and XIAP) and 12 fitness genes correlated with drug sensi…
View article: Figure 6 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Figure 6 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis Open
Proposed modes of mechanism of action of AZD5582 in OSCC. A, Upon activation by external death stimuli such as TNF, cIAP1/2 in OSCC trigger ubiquitination of RIP1, disabling its binding with FADD and CASP8 in the formation of ripopt…