Explanipedia

TopBP1 biomolecular condensates as a new therapeutic target in advanced-stage colorectal cancer Open

Laura Morano, Nadia Vezzio-Vié, Adam Aissanou, Tom Egger, Antoine Aze , et al. · 2025

In cancer cells, ATR signaling is crucial to tolerate the intrinsically high damage levels that normally block replication fork progression. Assembly of TopBP1, a multifunctional scaffolding protein, into condensates is required to amplify…

SAT-308 Unravelling Thermotolerance in Adrenocortical Carcinoma: Implications for Hyperthermia-Based Therapies Open

Solène Fiachetti, Nathan Mullen, Sarah Feely, Ritihaas Surya Challapalli, Padraig Donlon , et al. · 2025

Disclosure: S. Fiachetti: None. N. Mullen: None. S. Feely: None. R. Challapalli: None. P.T. Donlon: None. M. Hassany: None. M. O'Halloran: None. C. Hantel: None. P. Prakash: None. M.C. Dennedy: None. Introduction: Adrenocortical carcinoma …

Shining light on drug discovery: optogenetic screening for TopBP1 biomolecular condensate inhibitors Open

Laura Morano, Nadia Vié, Adam Aissanou, Dana Hodroj, Véronique Garambois , et al. · 2025

Human topoisomerase IIβ binding protein 1 (TopBP1) is a scaffold protein involved in DNA replication initiation, DNA repair, transcription regulation, and checkpoint activation. TopBP1 forms nuclear condensates that act as a molecular swit…

SAT-289 Rationally designed cholesterol coated peptide NS as a novel therapeutic strategy in the management of Adrenocortical Carcinoma Open

Mariam Hassany, Ritihaas Surya Challapalli, Obdulia Covarrubias‐Zambrano, Sarah Feely, Solène Fiachetti , et al. · 2025

Disclosure: M. Hassany: None. R. Challapalli: None. O. Covarrubias-Zambrano: None. S. Feely: None. S. Fiachetti: None. M. Luconi: None. M. O'Halloran: None. C. Hantel: None. P. Prakash: None. S. Bossmann: None. M.C. Dennedy: None. Manageme…

TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer Open

Laura Morano, Nadia Vezzio-Vié, Adam Aissanou, Tom Egger, Antoine Aze , et al. · 2025

In cancer cells, ATR signaling is crucial to tolerate the intrinsically high damage levels that normally block replication fork progression. Assembly of TopBP1, a multifunctional scaffolding protein, into condensates is required to amplify…

TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer Open

Laura Morano, Nadia Vezzio-Vié, Adam Aissanou, Tom Egger, Antoine Aze , et al. · 2025

In cancer cells, ATR signaling is crucial to tolerate the intrinsically high damage levels that normally block replication fork progression. Assembly of TopBP1, a multifunctional scaffolding protein, into condensates is required to amplify…

TopBP1 biomolecular condensates as a new therapeutic target in advanced-stage colorectal cancer Open

Laura Morano, Nadia Vezzio-Vié, Adam Aissanou, Tom Egger, Antoine Aze , et al. · 2025

Computer science Medicine Biology

In cancer cells, ATR signaling is crucial to tolerate the intrinsically high damage levels that normally block replication fork progression. Assembly of TopBP1, a multifunctional scaffolding protein, into condensates is required to amplify…

TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer Open

Laura Morano, Nadia Vezzio-Vié, Adam Aissanou, Tom Egger, Antoine Aze , et al. · 2024

Biology Chemistry

In cancer cells, ATR signaling is crucial to tolerate the intrinsically high damage levels that normally block replication fork progression. Assembly of TopBP1, a multifunctional scaffolding protein, into condensates is required to amplify…

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