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View article: Deficiency of antioxidant enzyme PRDX6 and mucosal chemokine CXCL17: unraveling the factors behind oxidative stress and mucosal homeostasis disruption in dry eye disease
Deficiency of antioxidant enzyme PRDX6 and mucosal chemokine CXCL17: unraveling the factors behind oxidative stress and mucosal homeostasis disruption in dry eye disease Open
This study aimed to identify dysregulated proteins in Schirmer strip samples (ScS) from Sjögren's syndrome dry eye (SSDE) patients to uncover key biological processes using untargeted proteomics. The focus then shifted to two dysregulated …
View article: Divergent responses to SARS-CoV-2 infection in bronchial epithelium with pre-existing respiratory diseases
Divergent responses to SARS-CoV-2 infection in bronchial epithelium with pre-existing respiratory diseases Open
View article: Dynamin 2 Orchestrates YAP/TAZ Mechanotransduction via Cortical Actin Remodeling
Dynamin 2 Orchestrates YAP/TAZ Mechanotransduction via Cortical Actin Remodeling Open
View article: Depleting trafficking regulator CASK promotes intercalated disc organization and ventricular function
Depleting trafficking regulator CASK promotes intercalated disc organization and ventricular function Open
Background The intercalated disc (ID) electromechanically couples adjacent cardiomyocytes. Alteration of this structure plays a central role in cardiac arrhythmias, notably arrhythmogenic cardiomyopathy (ACM), an inherited genetic disorder…
View article: Expanded biochemical analyses of human tear fluid: Polyvalent faces of the schirmer strip
Expanded biochemical analyses of human tear fluid: Polyvalent faces of the schirmer strip Open
View article: Profiling tear film enzymes reveals major metabolic pathways involved in the homeostasis of the ocular surface
Profiling tear film enzymes reveals major metabolic pathways involved in the homeostasis of the ocular surface Open
View article: Differential proteomics argues against a general role for CD9, CD81 or CD63 in the sorting of proteins into extracellular vesicles
Differential proteomics argues against a general role for CD9, CD81 or CD63 in the sorting of proteins into extracellular vesicles Open
The tetraspanins CD9, CD81 and CD63 are major components of extracellular vesicles (EVs). Yet, their impact on EV composition remains under‐investigated. In the MCF7 breast cancer cell line CD63 was as expected predominantly intracellular.…
View article: Profiling Tear Film Enzymes Reveals Major Metabolic Pathways Involved in the Homeostasis of the Ocular Surface
Profiling Tear Film Enzymes Reveals Major Metabolic Pathways Involved in the Homeostasis of the Ocular Surface Open
Background The role of ocular surface enzymes is of great interest. Therefore, this study first aimed to profile and classify enzymes identified on the ocular surface to describe major biological processes and pathways that are involved in…
View article: CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival
CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival Open
Objectives Inflammatory bowel disease (IBD) results from a combination of genetic predisposition, dysbiosis of the gut microbiota and environmental factors, leading to alterations in the gastrointestinal immune response and chronic inflamm…
View article: Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin
Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin Open
The molecular basis of interindividual clinical variability upon infection with Staphylococcus aureus is unclear. We describe patients with haploinsufficiency for the linear deubiquitinase OTULIN, encoded by a gene on chromosome 5p. Patien…
View article: CARD9 in Neutrophils Protects from Colitis and Controls Mitochondrial Metabolism and Cell Survival
CARD9 in Neutrophils Protects from Colitis and Controls Mitochondrial Metabolism and Cell Survival Open
Objectives Inflammatory bowel disease (IBD) results from a combination of genetic predisposition, dysbiosis of the gut microbiota and environmental factors, leading to alterations in the gastrointestinal immune response and chronic inflamm…
View article: Alzheimer's disease as an autoimmune disorder of innate immunity endogenously modulated by tryptophan metabolites
Alzheimer's disease as an autoimmune disorder of innate immunity endogenously modulated by tryptophan metabolites Open
Introduction Alzheimer's disease (AD) is characterized by neurotoxic immuno‐inflammation concomitant with cytotoxic oligomerization of amyloid beta (Aβ) and tau, culminating in concurrent, interdependent immunopathic and proteopathic patho…
View article: Proteomic Analysis of Tears and Conjunctival Cells Collected with Schirmer Strips Using timsTOF Pro: Preanalytical Considerations
Proteomic Analysis of Tears and Conjunctival Cells Collected with Schirmer Strips Using timsTOF Pro: Preanalytical Considerations Open
This study aimed to investigate the human proteome profile of samples collected from whole (W) Schirmer strips (ScS) and their two parts—the bulb (B) and the rest of the strip (R)—with a comprehensive proteomic approach using a trapped ion…
View article: Sublethal Exposure Effects of the Neonicotinoid Clothianidin Strongly Modify the Brain Transcriptome and Proteome in the Male Moth Agrotis ipsilon
Sublethal Exposure Effects of the Neonicotinoid Clothianidin Strongly Modify the Brain Transcriptome and Proteome in the Male Moth Agrotis ipsilon Open
Insect pest management relies mainly on neurotoxic insecticides, including neonicotinoids such as clothianidin. The residual accumulation of low concentrations of these insecticides can have positive effects on target pest insects by enhan…
View article: In‐depth proteomic analysis of <i>Plasmodium berghei</i> sporozoites using trapped ion mobility spectrometry with parallel accumulation‐serial fragmentation
In‐depth proteomic analysis of <i>Plasmodium berghei</i> sporozoites using trapped ion mobility spectrometry with parallel accumulation‐serial fragmentation Open
Sporozoites of the malaria parasite Plasmodium are transmitted by mosquitoes and infect the liver for an initial and obligatory round of replication, before exponential multiplication in the blood and onset of the disease. Sporozoites and …
View article: In-depth proteomic analysis of <i>Plasmodium berghei</i> sporozoites using trapped ion mobility spectrometry with parallel accumulation-serial fragmentation
In-depth proteomic analysis of <i>Plasmodium berghei</i> sporozoites using trapped ion mobility spectrometry with parallel accumulation-serial fragmentation Open
Malaria is caused by Plasmodium spp. protozoan parasites, which are transmitted by female anopheline mosquitoes in the form of sporozoites. Once deposited in the dermis during the blood meal of the mosquito, sporozoites rapidly migrate to …
View article: The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte Elimination
The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte Elimination Open
View article: Anti-integrin αv therapy improves cardiac fibrosis after myocardial infarction by blunting cardiac PW1+ stromal cells
Anti-integrin αv therapy improves cardiac fibrosis after myocardial infarction by blunting cardiac PW1+ stromal cells Open
There is currently no therapy to limit the development of cardiac fibrosis and consequent heart failure. We have recently shown that cardiac fibrosis post-myocardial infarction (MI) can be regulated by resident cardiac cells with a fibroge…
View article: Reverse Immunology Approach to Define a New HIV-gp41-Neutralizing Epitope
Reverse Immunology Approach to Define a New HIV-gp41-Neutralizing Epitope Open
The design of immunogens susceptible to elicit potent and broadly neutralizing antibodies against the human immunodeficiency virus type 1 (HIV-1) remains a veritable challenge in the course of vaccine development. Viral envelope proteins a…
View article: Identification of Plasmodium falciparum nuclear proteins by mass spectrometry and proposed protein annotation
Identification of Plasmodium falciparum nuclear proteins by mass spectrometry and proposed protein annotation Open
The nuclear proteome of Plasmodium falciparum results from the continual shuttle of proteins between the cell cytoplasm-nucleus and vice versa. Using shotgun proteomics tools, we explored the nuclear proteins of mixed populations of Plasmo…
View article: The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer Open
View article: Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation
Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation Open
Hyper-activation of extracellular signal-regulated kinase (ERK) 1/2 contributes to heart dysfunction in cardiomyopathy caused by mutations in the lamin A/C gene (LMNA cardiomyopathy). The mechanism of how this affects cardiac function is u…
View article: Protein profile of mouse ovarian follicles grown in vitro
Protein profile of mouse ovarian follicles grown in vitro Open
This study was supported by the Portuguese Foundation for Science and Technology, FCT (PhD fellowship SFRH/BD/65299/2009 to A.A.), the Swedish Childhood Cancer Foundation (PR 2014-0144 to K.A.R-.W.) and Stockholm County Council to K.A.R-.W…
View article: Neural Mechanisms Underlying the Disruption of Male Courtship Behavior by Adult Exposure to Di(2-ethylhexyl) Phthalate in Mice
Neural Mechanisms Underlying the Disruption of Male Courtship Behavior by Adult Exposure to Di(2-ethylhexyl) Phthalate in Mice Open
These data demonstrate the critical role of neural AR in courtship vocalizations and raises the possibility that the vulnerability of this signaling pathway to exposure to endocrine disrupters may be detrimental for courtship communication…
View article: Contents: Proteomics 9'16
Contents: Proteomics 9'16 Open
Lactobacillus acidophilus NCFM is a commonly used and well-studied probiotic bacterium.By the present differential proteome analysis, new insights into its synbiotic combination with the emerging prebiotic raffinose through comparative who…
View article: SASH1, a new potential link between smoking and atherosclerosis
SASH1, a new potential link between smoking and atherosclerosis Open