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View article: Characterization of <scp>WAC</scp> interactions with <scp>R2TP</scp> and <scp>TTT</scp> chaperone complexes linking glucose and glutamine availability to <scp>mTORC1</scp> activity
Characterization of <span>WAC</span> interactions with <span>R2TP</span> and <span>TTT</span> chaperone complexes linking glucose and glutamine availability to <span>mTORC1</span> activity Open
TELO2‐TTI1‐TTI2 (TTT) and R2TP are multi‐subunit chaperones that cooperate with HSP90 to assemble matured complexes of the PIKK family of kinases, including mTOR complex 1 (mTORC1). WAC, a protein previously implicated in transcription, H2…
View article: Mapping cancer gene dynamics through state-specific interactions
Mapping cancer gene dynamics through state-specific interactions Open
Metastatic cancer, a major cause of mortality, has been understudied compared to primary tumors, leaving gaps in our understanding of how cancer genes adapt between these states. We analyzed the association between mutations and copy numbe…
View article: p53 protein degradation redefines the initiation mechanisms and drives transitional mutations in colorectal cancer
p53 protein degradation redefines the initiation mechanisms and drives transitional mutations in colorectal cancer Open
Incidence of colorectal cancer (CRC) is increasing likely due to different mechanisms driving initiation and progression. The initial model proposed by Fearon and Vogelstein posits it as a multi-hit neoplasia, originating from adenomatous-…
View article: Mapping cancer gene dynamics through state-specific interactions
Mapping cancer gene dynamics through state-specific interactions Open
Metastatic cancer, a major cause of mortality, has been understudied compared to primary tumors, leaving gaps in our understanding of how cancer genes adapt between these states. We analyzed the association between mutations and copy-numbe…
View article: Systematic analysis of Mendelian disease-associated gene variants reveals new classes of cancer-predisposing genes
Systematic analysis of Mendelian disease-associated gene variants reveals new classes of cancer-predisposing genes Open
Background Despite the acceleration of somatic driver gene discovery facilitated by recent large-scale tumor sequencing data, the contribution of inherited variants remains largely unexplored, primarily focusing on previously known cancer …
View article: Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma
Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma Open
Background Lysosomes are closely linked to autophagic activity, which plays a vital role in pancreatic ductal adenocarcinoma (PDAC) biology. The survival of PDAC patients is still poor, and the identification of novel genetic factors for p…
View article: Author Correction: The impact of rare germline variants on human somatic mutation processes
Author Correction: The impact of rare germline variants on human somatic mutation processes Open
collected and curated the data, implemented software, performed all analyses, visualized the data, and interpreted the results.S.P. supervised the processing of common germline variants for the PCA analysis and the definition of rare germl…
View article: Lysosomal Storage Dysfunction, a Germline Variants Affecting Pancreatic Ductal Adenocarcinoma Development and Progression
Lysosomal Storage Dysfunction, a Germline Variants Affecting Pancreatic Ductal Adenocarcinoma Development and Progression Open
Lysosome is closely linked to autophagy, which plays a vital role in pancreatic adenocarcinoma (PDAC) tumor biology. This study investigated whether lysosome storage dysfunction (LSD) contributes to PDAC development. Germline putative path…
View article: Lysosomal Storage Dysfunction, a Germline Variants Affecting Pancreatic Ductal Adenocarcinoma Development and Progression
Lysosomal Storage Dysfunction, a Germline Variants Affecting Pancreatic Ductal Adenocarcinoma Development and Progression Open
Lysosome is closely linked to autophagy, which plays a vital role in pancreatic adenocarcinoma (PDAC) tumor biology. This study investigated whether lysosome storage dysfuncton(LSD) contributes to PDAC development. Germline putative pathog…
View article: Systematic analysis of disease-linked rare germline variants reveals new classes of cancer predisposing genes
Systematic analysis of disease-linked rare germline variants reveals new classes of cancer predisposing genes Open
Despite recent insights into cancer predisposition genes (CPGs), the contribution of rare germline variants to carcinogenesis remains unclear. Here, we examine the enrichment of rare germline variants in Mendelian disease-associated genes …
View article: Systematic analysis of disease-linked rare germline variants reveals new classes of cancer predisposing genes
Systematic analysis of disease-linked rare germline variants reveals new classes of cancer predisposing genes Open
GEMs_Liver-HCC: 312 cancer patient-specific genome-scale metabolic models (GEMs) for Liver-HCC reconstructed using the RNA-seq data from PCAWG-TCGA Liver-HCC samples and generic human GEM 'Recon 2M.2' GEMs_Lung-SCC: 493 cancer patient-spec…
View article: Systematic analysis of disease-linked rare germline variants reveals new classes of cancer predisposing genes
Systematic analysis of disease-linked rare germline variants reveals new classes of cancer predisposing genes Open
GEMs_Liver-HCC: 312 cancer patient-specific genome-scale metabolic models (GEMs) for Liver-HCC reconstructed using the RNA-seq data from PCAWG-TCGA Liver-HCC samples and generic human GEM 'Recon 2M.2' GEMs_Lung-SCC: 493 cancer patient-spec…
View article: Systematic discovery of germline cancer predisposition genes through large-scale cancer genomics
Systematic discovery of germline cancer predisposition genes through large-scale cancer genomics Open
The genetic causes of cancer include both somatic mutations and inherited germline
\nvariants. Large-scale tumor sequencing has revolutionized the identification of somatic
\ndriver alterations but has had limited impact on the identificat…
View article: Integrated Analysis of Germline and Tumor DNA Identifies New Candidate Genes Involved in Familial Colorectal Cancer
Integrated Analysis of Germline and Tumor DNA Identifies New Candidate Genes Involved in Familial Colorectal Cancer Open
Colorectal cancer (CRC) shows aggregation in some families but no alterations in the known hereditary CRC genes. We aimed to identify new candidate genes which are potentially involved in germline predisposition to familial CRC. An integra…