Somanon Bhattacharya
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View article: With age comes resilience: how mitochondrial modulation drives age-associated fluconazole tolerance in <i>Cryptococcus neoformans</i>
With age comes resilience: how mitochondrial modulation drives age-associated fluconazole tolerance in <i>Cryptococcus neoformans</i> Open
Cryptococcus neoformans ( Cn ) is an opportunistic fungal microorganism that causes life-threatening meningoencephalitis. During the infection, the microbial population is heterogeneously composed of cells with varying generational ages, w…
View article: Distinct effect of calorie restriction between congenic mating types of Cryptococcus neoformans
Distinct effect of calorie restriction between congenic mating types of Cryptococcus neoformans Open
View article: Achieving Resilience in Aging: How Mitochondrial Modulation Drives Age-associated Fluconazole Tolerance in<i>Cryptococcus neoformans</i>
Achieving Resilience in Aging: How Mitochondrial Modulation Drives Age-associated Fluconazole Tolerance in<i>Cryptococcus neoformans</i> Open
Cryptococcus neoformans ( Cn ) is an opportunistic fungal microorganism that causes life-threatening meningoencephalitis. During the infection, the microbial population is heterogeneously composed of cells with varying generational ages, w…
View article: 851. Metabolic Changes Contributing to Age-Associated Antifungal Tolerance in <i>Cryptococcus neoformans</i>
851. Metabolic Changes Contributing to Age-Associated Antifungal Tolerance in <i>Cryptococcus neoformans</i> Open
Background Cryptococcus neoformans (CN) is a facultative intracellular pathogen that divides asymmetrically, resulting in different phenotypes of the mother and daughter cells. After 8-10 divisions, mother cells become more resistant to ph…
View article: Patient-Derived Antibody Data Yields Development of Broadly Cross-Protective Monoclonal Antibody against ST258 Carbapenem-Resistant <i>Klebsiella pneumoniae</i>
Patient-Derived Antibody Data Yields Development of Broadly Cross-Protective Monoclonal Antibody against ST258 Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Open
Here, we present in vitro and in vivo data for the wzi50 CPS-specific monoclonal antibody MAb 24D11, demonstrating its cross-protective efficacy against three prominent win types ( wzi29 , wzi154 , and wzi50 ) of the carbapenem-resistant c…
View article: Novel ABC Transporter Associated with Fluconazole Resistance in Aging of Cryptococcus neoformans
Novel ABC Transporter Associated with Fluconazole Resistance in Aging of Cryptococcus neoformans Open
Cryptococcus neoformans causes meningoencephalitis in immunocompromised individuals, which is treated with fluconazole (FLC) monotherapy when resources are limited. This can lead to azole resistance, which can be mediated by overexpression…
View article: Replicative Aging Remodels the Cell Wall and Is Associated with Increased Intracellular Trafficking in Human Pathogenic Yeasts
Replicative Aging Remodels the Cell Wall and Is Associated with Increased Intracellular Trafficking in Human Pathogenic Yeasts Open
Cryptococcus neoformans and Candida glabrata are two opportunistic human fungal pathogens that cause life-threatening diseases. During infection, both microorganisms have the ability to persist for long periods, and treatment failure can o…
View article: Replicative Aging Remodels Cell Wall and is Associated with Increased Intracellular Trafficking in Human Pathogenic Yeasts
Replicative Aging Remodels Cell Wall and is Associated with Increased Intracellular Trafficking in Human Pathogenic Yeasts Open
Replicative aging is an underexplored field of research in medical mycology. Cryptococcus neoformans ( Cn ) and Candida glabrata ( Cg ) are dreaded fungal pathogens that cause fatal invasive infections. The fungal cell wall is essential fo…
View article: Novel ABC Transporter Associated with Fluconazole Resistance in Aging of Cryptococcus neoformans
Novel ABC Transporter Associated with Fluconazole Resistance in Aging of Cryptococcus neoformans Open
Cryptococcus neoformans causes meningoencephalitis in immunocompromised individuals, which is treated with Fluconazole (FLC) monotherapy when resources are limited. This can lead to azole resistance, which can be mediated by overexpression…
View article: Low Glucose Mediated Fluconazole Tolerance in Cryptococcus neoformans
Low Glucose Mediated Fluconazole Tolerance in Cryptococcus neoformans Open
Chronic meningoencephalitis is caused by Cryptococcus neoformans and is treated in many parts of the world with fluconazole (FLC) monotherapy, which is associated with treatment failure and poor outcome. In the host, C. neoformans propagat…
View article: Replicative Aging in Pathogenic Fungi
Replicative Aging in Pathogenic Fungi Open
Candida albicans, Candida auris, Candida glabrata, and Cryptococcus neoformans are pathogenic yeasts which can cause systemic infections in immune-compromised as well as immune-competent individuals. These yeasts undergo replicative aging …
View article: Candidiasis and Mechanisms of Antifungal Resistance
Candidiasis and Mechanisms of Antifungal Resistance Open
Candidiasis can be present as a cutaneous, mucosal or deep-seated organ infection, which is caused by more than 20 types of Candida sp., with C. albicans being the most common. These are pathogenic yeast and are usually present in the norm…
View article: Cell Wall-Associated Virulence Factors Contribute to Increased Resilience of Old Cryptococcus neoformans Cells
Cell Wall-Associated Virulence Factors Contribute to Increased Resilience of Old Cryptococcus neoformans Cells Open
As Cryptococcus neoformans mother cells generationally age, their cell walls become thicker and cell-wall associated virulence factors are upregulated. Antiphagocytic protein 1 (App1), and laccase enzymes (Lac1 and Lac2) are virulen…
View article: High-Throughput Yeast Aging Analysis for Cryptococcus (HYAAC) microfluidic device streamlines aging studies in Cryptococcus neoformans
High-Throughput Yeast Aging Analysis for Cryptococcus (HYAAC) microfluidic device streamlines aging studies in Cryptococcus neoformans Open
View article: Gene Duplication Associated with Increased Fluconazole Tolerance in Candida auris cells of Advanced Generational Age
Gene Duplication Associated with Increased Fluconazole Tolerance in Candida auris cells of Advanced Generational Age Open
View article: Overexpression or Deletion of Ergosterol Biosynthesis Genes Alters Doubling Time, Response to Stress Agents, and Drug Susceptibility in <i>Saccharomyces cerevisiae</i>
Overexpression or Deletion of Ergosterol Biosynthesis Genes Alters Doubling Time, Response to Stress Agents, and Drug Susceptibility in <i>Saccharomyces cerevisiae</i> Open
Ergosterol (ERG) is a critical sterol in the cell membranes of fungi, and its biosynthesis is tightly regulated by 25 known enzymes along the ERG production pathway. The effects of changes in expression of each ERG biosynthesis enzyme in S…
View article: Enhanced Efflux Pump Activity in Old Candida glabrata Cells
Enhanced Efflux Pump Activity in Old Candida glabrata Cells Open
We investigated the effect of replicative aging on antifungal resistance in Candida glabrata . Our studies demonstrate significantly increased transcription of ABC transporters and efflux pump activity in old versus young C. glabrata cells…
View article: Replicative Aging in Candida auris Has an Effect on Antifungal Resistance
Replicative Aging in Candida auris Has an Effect on Antifungal Resistance Open
Candida auris can colonize patients for a prolonged time causing life-threatening systemic infections. Replicative aging is the result of asymmetric division, which cause phenotypic changes between mother and daughter cells. We have previo…
View article: A Combination Fluorescence Assay Demonstrates Increased Efflux Pump Activity as a Resistance Mechanism in Azole-Resistant Vaginal Candida albicans Isolates
A Combination Fluorescence Assay Demonstrates Increased Efflux Pump Activity as a Resistance Mechanism in Azole-Resistant Vaginal Candida albicans Isolates Open
Candida albicans is a pathogenic fungus causing vulvovaginal candidiasis (VVC). Azole drugs, such as fluconazole, are the most common treatment for these infections. Recently, azole-resistant vaginal C. albicans isolates have been detected…