Somenath Banerjee
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View article: RGS2 is an innate immune checkpoint for suppressing Gαq-mediated IFNγ generation and lung injury
RGS2 is an innate immune checkpoint for suppressing Gαq-mediated IFNγ generation and lung injury Open
Interferon gamma (IFNγ), a type II interferon, augments tissue inflammation following infections, leading to lethal acute lung injury (ALI), yet the mechanisms controlling IFNγ generation in the lungs remain elusive. Here, we identified re…
View article: Endothelial ERG programs neutrophil transcriptome for sustained anti-inflammatory vascular niche
Endothelial ERG programs neutrophil transcriptome for sustained anti-inflammatory vascular niche Open
Neutrophils (PMNs) reside as a marginated pool within the vasculature, ready for deployment during infection. However, how endothelial cells (ECs) control PMN extravasation and activation to strengthen tissue homeostasis remains ill-define…
View article: RGS2 is an innate immune checkpoint for TLR4 and Gαq-mediated IFNγ generation and lung injury
RGS2 is an innate immune checkpoint for TLR4 and Gαq-mediated IFNγ generation and lung injury Open
Summary IFNγ, a type II interferon secreted by immune cells, augments tissue responses to injury following pathogenic infections leading to lethal acute lung injury (ALI). Alveolar macrophages (AM) abundantly express Toll-like receptor-4 a…
View article: Protease-activated receptor 2 promotes clearance of Pseudomonas aeruginosa infection by inducing cAMP-Rac1 signaling in alveolar macrophages
Protease-activated receptor 2 promotes clearance of Pseudomonas aeruginosa infection by inducing cAMP-Rac1 signaling in alveolar macrophages Open
Efficient phagocytosis of pathogens by the innate immune system during infectious injury is vital for restoring tissue integrity. Impaired phagocytosis, such as in the case of infection with Pseudomonas aeruginosa , a broad-spectrum antibi…
View article: A Co(III) Complex of 1-Amino-4-hydroxy-9,10-anthraquinone Exhibits Apoptotic Action against MCF-7 Human Breast Cancer Cells
A Co(III) Complex of 1-Amino-4-hydroxy-9,10-anthraquinone Exhibits Apoptotic Action against MCF-7 Human Breast Cancer Cells Open
A Co(III) complex of 1-amino-4-hydroxy-9,10-anthraquinone (QH) (Scheme-1) having the molecular formula CoQ3 (Scheme-2) was prepared and characterized by elemental analysis, FTIR spectroscopy, UV-vis spectroscopy, fluorescence spectroscopy,…
View article: Evidence for reprogramming of monocytes into reparative alveolar macrophages in vivo by targeting PDE4b
Evidence for reprogramming of monocytes into reparative alveolar macrophages in vivo by targeting PDE4b Open
Increased lung vascular permeability and neutrophilic inflammation are hallmarks of acute lung injury. Alveolar macrophages (AMϕ), the predominant sentinel cell type in the airspace, die in massive numbers while fending off pathogens. Rece…
View article: Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair
Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair Open
Macrophages play a central role in dictating the tissue response to infection and orchestrating subsequent repair of the damage. In this context, macrophages residing in the lungs continuously sense and discriminate among a wide range of i…
View article: Histidine based fluorescence probe for nanomolar magnesium(II)
Histidine based fluorescence probe for nanomolar magnesium(II) Open
Department of Chemistry, The University of Burdwan, Golapbag, Burdwan-713 104, West Bengal, India E-mail : [email protected] Fax : 91-342-2530452 Manuscript received online 20 February 2015, accepted 22 May 2015 A magnesium selective tur…
View article: CCDC 1420777: Experimental Crystal Structure Determination
CCDC 1420777: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Heat Killed Attenuated Leishmania Induces Apoptosis of HepG2 Cells Through ROS Mediated p53 Dependent Mitochondrial Pathway
Heat Killed Attenuated Leishmania Induces Apoptosis of HepG2 Cells Through ROS Mediated p53 Dependent Mitochondrial Pathway Open
Background/Aims: Cytotoxic effect of attenuated Leishmania on liver cancer cells by inducing ROS generation. Methods: Spectrophotometric study to analyze cell death and levels of different active caspases. Flow cytometric study was done to…