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View article: P-1331. Effect of Transfusion-Transmitted Infection Pre-Donation Deferrals on Subsequent Donations in a Military Blood Donation Center
P-1331. Effect of Transfusion-Transmitted Infection Pre-Donation Deferrals on Subsequent Donations in a Military Blood Donation Center Open
Background To minimize the risk of transfusion-transmitted infections (TTI), all prospective blood donors are required to undergo extensive screening via questionnaire and physical exam. Donors who report behaviors or conditions that may i…
View article: Retraction Note: Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD
Retraction Note: Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD Open
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13024-022-00564-6.
View article: 1785. Infectious Etiologies for Post-Donation Deferrals in a Military Blood Donation Center
1785. Infectious Etiologies for Post-Donation Deferrals in a Military Blood Donation Center Open
Background The burden of transfusion-transmitted infections (TTIs) among blood recipients remains low due to strict blood donor selection as well as extensive post-donation screening. However, the military has the unique challenge of provi…
View article: Infectious etiologies among <scp>post‐donation</scp> deferrals in a military blood donation center
Infectious etiologies among <span>post‐donation</span> deferrals in a military blood donation center Open
Background The burden of transfusion‐transmitted infections among blood recipients remains low due to extensive pre‐ and post‐donation screening. However, the military has the unique challenge of providing blood in austere environments wit…
View article: Inhibition of p38α MAPK restores neuronal p38γ MAPK and ameliorates synaptic degeneration in a mouse model of DLB/PD
Inhibition of p38α MAPK restores neuronal p38γ MAPK and ameliorates synaptic degeneration in a mouse model of DLB/PD Open
Alterations in the p38 mitogen-activated protein kinases (MAPKs) play an important role in the pathogenesis of dementia with Lewy bodies (DLB) and Parkinson’s disease (PD). Activation of the p38α MAPK isoform and mislocalization of the p38…
View article: RETRACTED ARTICLE: Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD
RETRACTED ARTICLE: Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD Open
Background Although ɑ-synuclein (ɑ-syn) spreading in age-related neurodegenerative diseases such as Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB) has been extensively investigated, the role of aging in the manifestation of d…
View article: Peripheral Blood from Rheumatoid Arthritis Patients Shows Decreased Treg CD25 Expression and Reduced Frequency of Effector Treg Subpopulation
Peripheral Blood from Rheumatoid Arthritis Patients Shows Decreased Treg CD25 Expression and Reduced Frequency of Effector Treg Subpopulation Open
Rheumatoid arthritis (RA) is a common autoimmune disease characterized by immune cell infiltration of the synovium, leading to the loss of cartilage, bone, and joint function. Although regulatory T (Treg) cells are thought to modulate the …
View article: Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits a mouse model of DLB/PD
Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits a mouse model of DLB/PD Open
ɑ-synuclein (ɑ-syn) progressively accumulates in age related neurodegenerative diseases such as Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB). Although ɑ-syn spreading has been extensively investigated, the role of aging in …
View article: LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies
LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies Open
LRRK2 modulates nucleus translocation of NFATc2 in microglia.
View article: Carrot Pomace Polysaccharide (CPP) Improves Influenza Vaccine Efficacy in Immunosuppressed Mice via Dendritic Cell Activation
Carrot Pomace Polysaccharide (CPP) Improves Influenza Vaccine Efficacy in Immunosuppressed Mice via Dendritic Cell Activation Open
Despite the advancements in vaccination research and practices, influenza viruses remain a global health concern. Inducing a robust immune response by vaccination is especially challenging in the elderly, the immunocompromised, and persons…
View article: Neuroinflammation is associated with infiltration of T cells in Lewy body disease and ɑ-synuclein transgenic models.
Neuroinflammation is associated with infiltration of T cells in Lewy body disease and ɑ-synuclein transgenic models. Open
Background: ɑ-synuclein (ɑ-syn) is a presynaptic protein which progressively accumulates in neuronal and non-neuronal cells in neurodegenerative diseases such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple syste…
View article: Role of Alterations in Protein Kinase p38γ in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and α-Synuclein Transgenic Models
Role of Alterations in Protein Kinase p38γ in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and α-Synuclein Transgenic Models Open
Progressive accumulation of the pre-synaptic protein α-synuclein (α-syn) has been strongly associated with the pathogenesis of neurodegenerative disorders of the aging population such as Alzheimer's disease (AD), Parkinson's disease (PD), …
View article: Targeting Microglial and Neuronal Toll-like Receptor 2 in Synucleinopathies
Targeting Microglial and Neuronal Toll-like Receptor 2 in Synucleinopathies Open
Synucleinopathies are neurodegenerative disorders characterized by the progressive accumulation of α-synuclein (α-syn) in neurons and glia and include Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In this review, we consoli…