Somnath Pandey
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View article: Assessment of cerebrovascular reserve using acetazolamide brain perfusion SPECT in Moyamoya disease
Assessment of cerebrovascular reserve using acetazolamide brain perfusion SPECT in Moyamoya disease Open
Objective(s): Moyamoya disease (MMD) is a rare, progressive steno-occlusive cerebrovascular disorder characterized by impaired cerebral perfusion and an elevated risk of ischemic events. Accurate cerebrovascular reserve (CVR) assessment is…
View article: Cross-Fostering with control dams rescues Gut Dysbiosis and Chromatin-associated Transcriptional Changes in Offspring of Opioid-Exposed Dams
Cross-Fostering with control dams rescues Gut Dysbiosis and Chromatin-associated Transcriptional Changes in Offspring of Opioid-Exposed Dams Open
Prenatal opioid exposure disrupts gut homeostasis and causes gastrointestinal complications in offspring, but the mechanisms remain unclear. Here using a murine model of prenatal hydromorphone exposure, we examined gut microbiota, intestin…
View article: Role of Epigenetics in Pancreatic Ductal Adenocarcinoma
Role of Epigenetics in Pancreatic Ductal Adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, associated with poor survival outcomes. Lack of early diagnosis, resistance to conventional therapeutic treatments (including immunotherapy) and recurrence are …
View article: Selective CDK9 Inhibition by Natural Compound Toyocamycin in Cancer Cells
Selective CDK9 Inhibition by Natural Compound Toyocamycin in Cancer Cells Open
Aberrant transcription in cancer cells involves the silencing of tumor suppressor genes (TSGs) and activation of oncogenes. Transcriptomic changes are associated with epigenomic alterations such as DNA-hypermethylation, histone deacetylati…
View article: Identification of Novel MeCP2 Cancer-Associated Target Genes and Post-Translational Modifications
Identification of Novel MeCP2 Cancer-Associated Target Genes and Post-Translational Modifications Open
Abnormal regulation of DNA methylation and its readers has been associated with a wide range of cellular dysfunction. Disruption of the normal function of DNA methylation readers contributes to cancer progression, neurodevelopmental disord…
View article: Functional assessment of MeCP2 in Rett syndrome and cancers of breast, colon, and prostate
Functional assessment of MeCP2 in Rett syndrome and cancers of breast, colon, and prostate Open
Ever since the first report that mutations in methyl-CpG-binding protein 2 (MeCP2) causes Rett syndrome (RTT), a severe neurological disorder in females world-wide, there has been a keen interest to gain a comprehensive understanding of th…