Sonal Sharma
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View article: Comparison of programmed death-1 (PD-1)-positive T-cells with known prognostic indicators in breast cancer
Comparison of programmed death-1 (PD-1)-positive T-cells with known prognostic indicators in breast cancer Open
A BSTRACT Background: Breast cancer is the most common cancer in women across the world. Immune cells can detect and destroy cancer cells. However, cancer cells acquire certain immune evasion mechanisms such as PD-1+ T-cells, to combat imm…
View article: Agreement among Observers with Variable Experience in the Implementation of the Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology
Agreement among Observers with Variable Experience in the Implementation of the Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology Open
Background: Fine needle aspiration biopsy (FNAB) breast remains the prime investigation in distinguishing benign breast lesions from malignant ones in low socioeconomic settings. To overcome the problems of non-uniform reporting systems in…
View article: Safety Monitoring of Omaveloxolone in Friedreich Ataxia: Results from One Year of Clinical Treatment
Safety Monitoring of Omaveloxolone in Friedreich Ataxia: Results from One Year of Clinical Treatment Open
Most patients with FRDA eventually had access to omaveloxolone, and it was generally well tolerated. Side effects were modest, and, overall, most patients remained on the drug. Abnormalities in serum liver function tests were limited to tr…
View article: Navigating through the complexities of bullous presentation of cutaneous lichen planus: A comparative study
Navigating through the complexities of bullous presentation of cutaneous lichen planus: A comparative study Open
Introduction: Bullous spectrum of cutaneous lichen planus has two distinct forms lichen planus pemphigoids (LPPs) and bullous lichen planus (BLP). There is paucity of literature on the clinical, histopathological, and immunological profile…
View article: Invasive stratified mucin-producing carcinoma of the cervix: A case report and review of the literature
Invasive stratified mucin-producing carcinoma of the cervix: A case report and review of the literature Open
Invasive stratified mucin-producing carcinoma (ISMC) is a rare, recently described subtype of HPV-associated cervical adenocarcinoma. It shows varied morphological patterns, making it difficult to diagnose, especially the mixed forms. A 57…
View article: Cytoplasmic Expression of p16 Is Associated with Carcinoma Breast: It Is Not an Artifact
Cytoplasmic Expression of p16 Is Associated with Carcinoma Breast: It Is Not an Artifact Open
The cytoplasmic localization of p16 immunohistochemistry is not seen in epithelial components of fibroadenoma, while it is seen frequently in breast carcinoma. Nuclear p16 expression has a statistically significant correlation with molecul…
View article: Novel Development of Magnetic Resonance Imaging to Quantify the Structural Anatomic Growth of Diverse Organs in Adult and Mutant Zebrafish
Novel Development of Magnetic Resonance Imaging to Quantify the Structural Anatomic Growth of Diverse Organs in Adult and Mutant Zebrafish Open
Zebrafish (Danio rerio) is a widely used vertebrate animal for modeling genetic diseases by targeted editing strategies followed by gross phenotypic and biomarker characterization. While larval transparency permits microscopic detection of…
View article: Giant Placental Chorioangioma in a Young Patient Causing Adverse Fetal Outcome
Giant Placental Chorioangioma in a Young Patient Causing Adverse Fetal Outcome Open
Chorioangiomas are benign vascular tumors of the placenta originating from chorionic tissue. They are also known as hemangiomas of the placenta. They occur in approximately 0.5%–1% of all pregnancies. Large chorioangiomas are rare and may …
View article: Omaveloxolone for the Treatment of Friedreich’s Ataxia
Omaveloxolone for the Treatment of Friedreich’s Ataxia Open
Friedrich’s ataxia (FRDA), a neurodevelopmental and progressive neurodegenerative disease, is the most common inherited form of ataxia. Omaveloxolone was approved by the US Food and Drugs Administration in early 2023, making it the first t…
View article: Diagnostic yield of genetic testing in 324 infants with hypotonia
Diagnostic yield of genetic testing in 324 infants with hypotonia Open
This retrospective cohort study was designed to determine the yield of genetic tests in hypotonic infants and develop a diagnostic algorithm. Out of 496 patients identified by International Classification of Diseases (ICD) 9/10 coding, 324…
View article: Crescents in Kidney Biopsy – What Do They Imply? A Clinicopathologic Study of 40 Cases in a Tertiary Care Center
Crescents in Kidney Biopsy – What Do They Imply? A Clinicopathologic Study of 40 Cases in a Tertiary Care Center Open
Introduction: Crescents in glomeruli mean proliferation of parietal epithelium of Bowman's capsule with the presence of macrophages, lymphocytes, neutrophils, fibrin, and collagen. When crescents are present in >50% of nonfibrosed glomerul…
View article: Clinicopathological Spectrum of Renal Amyloidosis in Young
Clinicopathological Spectrum of Renal Amyloidosis in Young Open
Amyloidosis is a complex multi-system disorder characterized by deposition of an aberrant protein in tissues with kidney being the main target organ. The age of presentation of amyloid A (AA) amyloidosis is highest among adults aged 60-80 …
View article: Y-Box binding protein 1 expression in breast cancer and its correlation with hormone receptors and other prognostic markers
Y-Box binding protein 1 expression in breast cancer and its correlation with hormone receptors and other prognostic markers Open
INTRODUCTION: The present histologic and immunohistochemical prognostic markers of breast carcinoma do not effectively identify the subset of patients with poor prognosis. Y-Box binding protein 1 (YB1) is a novel biomarker which may identi…
View article: Malignant transformation in mature cystic teratoma of the ovary: a retrospective study of eight cases and review of literature
Malignant transformation in mature cystic teratoma of the ovary: a retrospective study of eight cases and review of literature Open
The rate of malignant transformation in MCT increases with age and is much higher in the postmenopausal age group. Moreover, although SCC is still the commonest, transitional cell carcinoma (TCC) may also develop not infrequently as malign…
View article: Qualitative defects with normal sperm counts in a patient attending infertility clinic
Qualitative defects with normal sperm counts in a patient attending infertility clinic Open
Qualitative defects are often seen even in cases with normal sperm counts.
View article: Follicular variant of ameloblastoma mandible reconstructed with free fibula: a case report
Follicular variant of ameloblastoma mandible reconstructed with free fibula: a case report Open
Ameloblastoma is a tumor of odontogenic epithelium arising from remnants of dental lamina. It is a benign tumor but locally invasive affecting mandible more than maxilla. Ameloblastomas grow into the bone and soft tissues causing facial di…
View article: Cutaneous basal cell carcinoma with mixed histology: Cytomorphological features of two unusual cases
Cutaneous basal cell carcinoma with mixed histology: Cytomorphological features of two unusual cases Open
Cutaneous basal cell carcinoma (BCC) is a slow growing locally aggressive malignant tumor. It is usually diagnosed on histopathological examination of the excised biopsy. Recently, fine needle aspiration cytology (FNAC) is emerging as a si…
View article: Revisiting the Utility of Histopathological Examination of Biopsy: A Necessity in Microbiology
Revisiting the Utility of Histopathological Examination of Biopsy: A Necessity in Microbiology Open
We advocate using histopathology, culture and KOH examination in an integral manner to avoid potential lapses in patient management.
View article: Clinicopathological Evaluation of 223 Cases of Mature Cystic Teratoma, Ovary: 25-Year Experience in a Single Tertiary Care Centre in India
Clinicopathological Evaluation of 223 Cases of Mature Cystic Teratoma, Ovary: 25-Year Experience in a Single Tertiary Care Centre in India Open
MCT are most common tumours of the ovary. Though predominantly seen in reproductive age group, they may also be seen in children and postmenopausal women. Torsion is the most common complication of this tumour. Age of the patient and the s…
View article: Renal biopsy in paroxysmal nocturnal hemoglobinuria: An insight into the spectrum of morphologic changes
Renal biopsy in paroxysmal nocturnal hemoglobinuria: An insight into the spectrum of morphologic changes Open
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, potentially life-threatening disease of blood, characterized by complement-induced intravascular hemolytic anemia and thrombosis. PNH can sometimes present directly with renal …
View article: Pilot initiative in India to explore the gonadal function and fertility outcomes of a cohort of childhood cancer survivors
Pilot initiative in India to explore the gonadal function and fertility outcomes of a cohort of childhood cancer survivors Open
CONTEXT: Steady improvement in childhood cancer outcomes has led to a growing number of survivors, many of who develop long-term sequelae. There is limited data about these sequelae (including those related to fertility) on childhood cance…
View article: Bilateral Xanthogranulomatous Orchiepididymitis in a Diabetic Patient
Bilateral Xanthogranulomatous Orchiepididymitis in a Diabetic Patient Open
Xanthogranulomatous orchiepididymitis is a rare lesion characterized by the destruction of testicular parenchyma and its replacement by cellular infiltrate consisting predominantly of foamy histiocytes [1,2]. Bilaterality is an extremely r…
View article: Correlation of foxl2 with inhibin and calretinin in the diagnosis of ovarian sex cord stromal tumors
Correlation of foxl2 with inhibin and calretinin in the diagnosis of ovarian sex cord stromal tumors Open
In contrast to inhibin and calretinin, FOXL2 had a sensitivity and specificity of 100% for all the cases of sex cord stromal tumors included in this study.