Sonali Shinde
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View article: Design, Synthesis, <i>In-Silico</i> Study of Novel Benzofuran Thiazolyl Hydrazones as Anticancer Agents Targeting EGFR Kinase
Design, Synthesis, <i>In-Silico</i> Study of Novel Benzofuran Thiazolyl Hydrazones as Anticancer Agents Targeting EGFR Kinase Open
In the current investigation, a series of new benzofuran-thiazolyl hydrazones 5(a–h) were synthesized, characterized, and tested for anticancer activity against selected cancer cell lines, including A549, MCF-7, and DU-145, using MTT and E…
View article: Ratio Versus Difference Optimisation in Human Behaviour
Ratio Versus Difference Optimisation in Human Behaviour Open
Models of optimization have played an important role in the fields of evolution as well as economics. In the classical models of optimization, some tend to maximize the ratio of returns to investment, and others tend to maximize the differ…
View article: Exploring Recent Advancements in the Pharmacological Activities of Plant-derived Alkaloids and Glycosides: A Review
Exploring Recent Advancements in the Pharmacological Activities of Plant-derived Alkaloids and Glycosides: A Review Open
A wide spectrum of bioactive compounds is synthesised by plants, and these agents act as protection systems against different living and non-living stressors. They are also useful in the manufacturing of pharmaceutical medications which al…
View article: Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects
Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects Open
Phytochemicals, naturally occurring compounds in plants, possess a wide range of therapeutic properties, including antioxidant, anti-inflammatory, anticancer, and antimicrobial activities. However, their clinical application is often hinde…
View article: Synthesis, biological evaluation, and computational studies of thiazolyl hydrazone derivatives as triple mutant allosteric EGFR inhibitors
Synthesis, biological evaluation, and computational studies of thiazolyl hydrazone derivatives as triple mutant allosteric EGFR inhibitors Open
Herein, new thiazole‐2‐yl‐based hydrazone derivatives were synthesized and assessed for in vitro anticancer activity against wild type A549, MCF7, DU145, and mutant H1975 cancer cell lines by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetraz…
View article: Computational and Synthetic Approach with Biological Evaluation of Substituted Thiazole Derivatives as Small Molecule L858R/T790M/C797S Triple Mutant EGFR Inhibitors Targeting Resistance in Non-Small Cell Lung Cancer (NSCLC)
Computational and Synthetic Approach with Biological Evaluation of Substituted Thiazole Derivatives as Small Molecule L858R/T790M/C797S Triple Mutant EGFR Inhibitors Targeting Resistance in Non-Small Cell Lung Cancer (NSCLC) Open
The present research work explains the potential of novel substituted thiazole derivatives as anticancer agents along with molecular docking, DFT, ADMET, drug-likeness, and dynamics by simple chemical reaction. The synthesized derivatives …
View article: Exploring binding potential of two new indole alkaloids from <i>Nauclea officinalis</i> against third and fourth generation EGFR: druglikeness, <i>in silico</i> ADMET, docking, DFT, molecular dynamics simulation, and MMGBSA study
Exploring binding potential of two new indole alkaloids from <i>Nauclea officinalis</i> against third and fourth generation EGFR: druglikeness, <i>in silico</i> ADMET, docking, DFT, molecular dynamics simulation, and MMGBSA study Open
This study investigates the anti-cancer potential of recently discovered indole alkaloids from Nauclea Officinalis against third and fourth-generation EGFR mutations using computational tools. Through ADMET profiling, druglikeness predicti…
View article: Ratio versus difference optimization in human behavior
Ratio versus difference optimization in human behavior Open
Models of optimization have played an important role in the fields of evolution as well as economics. In the classical models of optimization, some tend to maximize the ratio of returns to investment and others tend to maximize the net ben…
View article: Therapeutic Delivery of Tumor Suppressor miRNAs for Breast Cancer Treatment
Therapeutic Delivery of Tumor Suppressor miRNAs for Breast Cancer Treatment Open
The death rate from breast cancer (BC) has dropped due to early detection and sophisticated therapeutic options, yet drug resistance and relapse remain barriers to effective, systematic treatment. Multiple mechanisms underlying miRNAs appe…
View article: The Advancement of Herbal-Based Nanomedicine for Hair
The Advancement of Herbal-Based Nanomedicine for Hair Open
Polymer, lipid, and natural protein-based hair care nanocarriers are in preclinical testing. Nanomedicine has enhanced therapeutic efficacy and decreased side effects. This review examines herbal nanomedicine for hair care. We also reviewe…
View article: The ratio versus difference optimization and its implications for optimality theory
The ratio versus difference optimization and its implications for optimality theory Open
Among the classical models of optimization, some models maximize the ratio of returns to investment and others maximize the difference between returns and investment. However, an understanding of under what conditions the ratio or the diff…
View article: Peer Review #2 of "Evaluating alternative hypotheses to explain the downward trend in the indices of the COVID-19 pandemic death rate (v0.2)"
Peer Review #2 of "Evaluating alternative hypotheses to explain the downward trend in the indices of the COVID-19 pandemic death rate (v0.2)" Open
Background: In the ongoing Covid-19 pandemic, in the global data on the case fatality ratio (CFR) and other indices reflecting death rate, there is a consistent downward trend from mid-April to mid-November.The downward trend can be an ill…
View article: Evaluating alternative hypotheses to explain the downward trend in the indices of the COVID-19 pandemic death rate
Evaluating alternative hypotheses to explain the downward trend in the indices of the COVID-19 pandemic death rate Open
Background In the ongoing Covid-19 pandemic, in the global data on the case fatality ratio (CFR) and other indices reflecting death rate, there is a consistent downward trend from mid-April to mid-November. The downward trend can be an ill…
View article: Peer Review #1 of "Evaluating alternative hypotheses to explain the downward trend in the indices of the COVID-19 pandemic death rate (v0.1)"
Peer Review #1 of "Evaluating alternative hypotheses to explain the downward trend in the indices of the COVID-19 pandemic death rate (v0.1)" Open
Background: In the ongoing Covid-19 pandemic, in the global data on the case fatality ratio (CFR) and other indices reflecting death rate, there is a consistent downward trend from mid-April to mid-November.The downward trend can be an ill…
View article: Peer Review #2 of "Evaluating alternative hypotheses to explain the downward trend in the indices of the COVID-19 pandemic death rate (v0.1)"
Peer Review #2 of "Evaluating alternative hypotheses to explain the downward trend in the indices of the COVID-19 pandemic death rate (v0.1)" Open
Background: In the ongoing Covid-19 pandemic, in the global data on the case fatality ratio (CFR) and other indices reflecting death rate, there is a consistent downward trend from mid-April to mid-November.The downward trend can be an ill…
View article: The ratio versus difference optimization and its implications for optimality theory
The ratio versus difference optimization and its implications for optimality theory Open
Among the classical models of optimization, some models maximize the ratio of returns per investment, others maximize the difference between returns and investment. However, the question under what conditions use of the ratio model is appr…
View article: Downward Trend in the Indices of Death Rate in the COVID-19 Pandemic: Evaluating Alternative Hypotheses
Downward Trend in the Indices of Death Rate in the COVID-19 Pandemic: Evaluating Alternative Hypotheses Open
In the ongoing Covid-19 pandemic, in the global data on the case fatality ratio and other indices reflecting death rate, there is a consistent downward trend from mid-April to mid-August. The downward trend can be an illusion caused by bia…
View article: Downward trend in the indices of death rate in the Covid-19 pandemic: Evaluating alternative hypotheses
Downward trend in the indices of death rate in the Covid-19 pandemic: Evaluating alternative hypotheses Open
In the ongoing Covid-19 pandemic, in the global data on the case fatality ratio and other indices reflecting death rate, there is a consistent downward trend from mid-April to mid-August. The downward trend can be an illusion caused by bia…
View article: To Assess the Quality of Life among Primary Caregivers of Intellectually Disabled Children Attending Outpatient Department in a Tertiary Health Center of City
To Assess the Quality of Life among Primary Caregivers of Intellectually Disabled Children Attending Outpatient Department in a Tertiary Health Center of City Open
Introduction:Acceptance of child with intellectual disability (ID), once called mental retardation, becomes difficult to parents and the whole family, particularly when competence and achievement are very much valued in modern world.A pare…