Saifullah Khan
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View article: Comparison of Cold-Cup Biopsy Versus Resection Biopsy in the Early Detection of Detrusor Muscle Invasion in the Case of Bladder Tumor
Comparison of Cold-Cup Biopsy Versus Resection Biopsy in the Early Detection of Detrusor Muscle Invasion in the Case of Bladder Tumor Open
Bladder cancer continues to represent a major global health burden, and accurate early staging is crucial for planning an appropriate treatment strategy regarding the presence of detrusor muscle (DM) invasion. This is a prospective observa…
View article: Comparison of the Effectiveness of Tamoxifen and Mitomycin C in the Prevention of Recurrent Urethral Stricture Following Internal Optical Urethrotomy (IOU): A Randomized Controlled Trial
Comparison of the Effectiveness of Tamoxifen and Mitomycin C in the Prevention of Recurrent Urethral Stricture Following Internal Optical Urethrotomy (IOU): A Randomized Controlled Trial Open
Internal optical urethrotomy (IOU) is a common surgical procedure for treating anterior urethral strictures, but recurrence remains a significant concern. The aim of the study is to compare the effectiveness of oral tamoxifen versus mitomy…
View article: Preparation and topographical studies of various biological specimens using alternate method to critical point drying: Scanning electron microscopy
Preparation and topographical studies of various biological specimens using alternate method to critical point drying: Scanning electron microscopy Open
Background: The major advantage of scanning electron microscope (SEM) in biological research is that one can examine the morphology and surface features of specimens at high resolution. Specimens may differ from individual cells grown in c…
View article: The role of diode laser assistance in functional endoscopic sinus surgery to reduce perioperative morbidity.
The role of diode laser assistance in functional endoscopic sinus surgery to reduce perioperative morbidity. Open
Objectives: To compare the mean duration of hospital stay and frequency of postoperative haemorrhage in patients undergoing FESS with or without Diode laser-assistance. Study Design: Single-blinded Randomized Controlled Trial. Setting: Dep…
View article: Japanese Encephalitis Virus in Pakistan: An Update and Way Forward
Japanese Encephalitis Virus in Pakistan: An Update and Way Forward Open
Japanese encephalitis (JE) is the leading form of mosquito borne viral encephalitis in Asia, with about 100,000 annual cases in which children are more dominant. The causative agent of JE is Japanese encephalitis virus (JEV) which is trans…
View article: Detection of Genetic Modification in Crops by Polymerase Chain Reaction
Detection of Genetic Modification in Crops by Polymerase Chain Reaction Open
Human beings have a long history of changing crops’ characteristics by selective and crossbreeding. However, with the advancement in science and technology, genetic modification in crops is possible to add cross specie characteristics like…
View article: Efficacy of the Electrocardiographic P-Wave Indices (PWIs) in Predicting Atrial High-Rate Episodes (AHREs) With Cardiac Implantable Electronic Devices (CIEDs)
Efficacy of the Electrocardiographic P-Wave Indices (PWIs) in Predicting Atrial High-Rate Episodes (AHREs) With Cardiac Implantable Electronic Devices (CIEDs) Open
Atrial fibrillation (AF) is a common arrhythmia that increases the risk of stroke and mortality. Patients with AF who have cardiac implantable electronic devices (CIEDs) are at risk of developing atrial high-rate episodes (AHREs), which ca…
View article: The Ultrasonographic Correlation of Hepatic Steatosis with Hypertension and Diabetes Mellitus
The Ultrasonographic Correlation of Hepatic Steatosis with Hypertension and Diabetes Mellitus Open
Background: Hepatic steatosis, commonly known as fatty liver disease, represents a significant public health challenge, increasingly associated with metabolic syndromes such as hypertension and Type 2 Diabetes Mellitus (T2DM). This study i…
View article: One-year outcomes of anterior–posterior vs. anterior-lateral method of cardioversion for atrial fibrillation: a tertiary center experience
One-year outcomes of anterior–posterior vs. anterior-lateral method of cardioversion for atrial fibrillation: a tertiary center experience Open
This retrospective cohort study aimed to compare the one-year outcomes of anterior–posterior (AP) and anterior—lateral (AL) methods of cardioversion for atrial fibrillation (AF). A total of 2168 patients were included, with 1125 patients i…
View article: Sensitivity and Specificity of Color Doppler Ultrasound Measurement in the Evaluation of Renal Artery Stenosis
Sensitivity and Specificity of Color Doppler Ultrasound Measurement in the Evaluation of Renal Artery Stenosis Open
Renal artery stenosis typically results from plaque development. Mostly frequent cause of severe hypertension is RAS, which affects 1% to 5% of all patients with hypertension. Objective: To assess the sensitivity and specificity of Doppler…
View article: Cellular senescence in brain aging and cognitive decline
Cellular senescence in brain aging and cognitive decline Open
Cellular senescence is a biological aging hallmark that plays a key role in the development of neurodegenerative diseases. Clinical trials are currently underway to evaluate the effectiveness of senotherapies for these diseases. However, t…
View article: Post-Traumatic Stress Disorder (PTSD) Among Healthcare Workers of Tertiary Care Hospitals of Rawalpindi; Amid the COVID-19 Pandemic
Post-Traumatic Stress Disorder (PTSD) Among Healthcare Workers of Tertiary Care Hospitals of Rawalpindi; Amid the COVID-19 Pandemic Open
Objective: To determine the prevalence of PTSD symptoms and its severity among HCWs, amid the COVID pandemic in a tertiary care setting. Study Design: Cross sectional analytic study. Place and Duration of Study: Pakistan Emirates Military …
View article: Dental care of the pregnant patient: an update of guidelines and recommendations
Dental care of the pregnant patient: an update of guidelines and recommendations Open
Pregnancy is a dynamic state marked by several physiological changes. Oral healthcare in pregnancy is often avoided and misunderstood, with healthcare professionals struggling to interpret the safety and appropriateness of dental treatment…
View article: P1187: SAFETY AND EFFICACY OF ANTICD20-CD3 BISPECIFIC T-CELL ENGAGING ANTIBODIES IN THE MANAGEMENT OF RELAPSED/REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA: A SYSTEMATIC REVIEW OF CLINICAL TRIALS
P1187: SAFETY AND EFFICACY OF ANTICD20-CD3 BISPECIFIC T-CELL ENGAGING ANTIBODIES IN THE MANAGEMENT OF RELAPSED/REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA: A SYSTEMATIC REVIEW OF CLINICAL TRIALS Open
Topic: 19. Aggressive Non-Hodgkin lymphoma - Clinical Background: Relapsed/refractory diffuse large B-cell lymphoma (RRDLBCL) represents a major sub-group of non-Hodgkin lymphoma. Patients with RRDLBCL have poor clinical outcomes due to su…
View article: Climate and Weather Condition of Balochistan Province, Pakistan
Climate and Weather Condition of Balochistan Province, Pakistan Open
The study discusses the climate of Balochistan with a special focus on the variation of weather condition taking into account the mean monthly precipitation, temperature, humidity, atmospheric circulation, air pressure, evapotranspiration …
View article: Seroprevalence of Dengue Virus by Detection of IgG Antibodies: A Tertiary Care Hospital Study in Rawalpindi
Seroprevalence of Dengue Virus by Detection of IgG Antibodies: A Tertiary Care Hospital Study in Rawalpindi Open
Objective: To determine the seroprevalence of dengue virus infection by detecting IgG antibodies in a tertiary care hospital in Rawalpindi. Study Design: Cross sectional study. Place and Duration of Study: Virology department, Armed Forces…
View article: Proteome-Wide Screening of Potential Vaccine Targets against Brucella melitensis
Proteome-Wide Screening of Potential Vaccine Targets against Brucella melitensis Open
The ongoing antibiotic-resistance crisis is becoming a global problem affecting public health. Urgent efforts are required to design novel therapeutics against pathogenic bacterial species. Brucella melitensis is an etiological agent of br…
View article: Rotavirus Samples processing using Indigenously Developed Molecular Transport Medium (IMTM)
Rotavirus Samples processing using Indigenously Developed Molecular Transport Medium (IMTM) Open
Objective: To perform comparative diagnostic study with rotavirus infected stool samples for efficacy ofindigenously prepared molecular transport medium (IMTM).Study Design: It was an experimental study.Place and Duration of Study: The stu…
View article: Identification of potential drug molecules against fibroblast growth factor receptor 3 (FGFR3) by multi-stage computational-biophysics correlate
Identification of potential drug molecules against fibroblast growth factor receptor 3 (FGFR3) by multi-stage computational-biophysics correlate Open
The fibroblast growth factor receptor 3 (FGFR3) is warranted as a promising therapeutic target in bladder cancer as it is described in 75% of papillary bladder tumors. Considering this, the present study was conducted to use different appr…
View article: A chemoinformatic-biophysics based approach to identify novel anti-virulent compounds against <i>Pseudomonas aeruginosa</i> disulfide-bond protein A1
A chemoinformatic-biophysics based approach to identify novel anti-virulent compounds against <i>Pseudomonas aeruginosa</i> disulfide-bond protein A1 Open
The conventional course of drug discovery is a lengthy, expensive and complex process and often experiences a high failure rate. This in-silico based study screened novel drug molecules against Pseudomonas aeruginosa disulfide-bond protein…
View article: Effect of soil amendments on the sorption behaviour of atrazine in sandy loam soil
Effect of soil amendments on the sorption behaviour of atrazine in sandy loam soil Open
The behaviour of pesticides applied during cultivation of crops is affected by usage of amendments like farm yard manure (FYM) and vermicompost (VC) during land preparation. Among pesticides, atrazine, a widely used herbicide in many crops…
View article: Herpes Simplex Virus Encephalitis: An Unexpected Outcome in a Polytrauma Patient
Herpes Simplex Virus Encephalitis: An Unexpected Outcome in a Polytrauma Patient Open
An 84-year male was brought in the emergency after a road traffic accident leading to polytrauma with deteriorating consciousness.Prolonged unexplained unconsciousness led to cerebrospinal fluid examination.The polymerase chain reaction (P…
View article: Virtual Screening of Artemisia annua Phytochemicals as Potential Inhibitors of SARS-CoV-2 Main Protease Enzyme
Virtual Screening of Artemisia annua Phytochemicals as Potential Inhibitors of SARS-CoV-2 Main Protease Enzyme Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a human coronaviruses that emerged in China at Wuhan city, Hubei province during December 2019. Subsequently, SARS-CoV-2 has spread worldwide and caused millions of deaths aro…
View article: Virtual screening and drug repositioning of FDA-approved drugs from the ZINC database to identify the potential hTERT inhibitors
Virtual screening and drug repositioning of FDA-approved drugs from the ZINC database to identify the potential hTERT inhibitors Open
The length of the telomeres is maintained with the help of the enzyme telomerase constituting of two components, namely, a core reverse transcriptase protein (hTERT) and RNA (hTR). It serves as a significant and universal cancer target. In…