Sonata Jarmalaitė
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View article: The utility of miR-16, miR-146a and miR-155 in serum and urine for juvenile idiopathic arthritis diagnostics and monitoring
The utility of miR-16, miR-146a and miR-155 in serum and urine for juvenile idiopathic arthritis diagnostics and monitoring Open
This study highlights the utility of miRNAs in JIA diagnosis, monitoring and prognosis and demonstrates the feasibility of using urine as a noninvasive source of miRNAs in children with non-systemic JIA.
View article: Genomic analysis of small renal masses reveals mutations linked with renal cell carcinoma and fast-growing tumors
Genomic analysis of small renal masses reveals mutations linked with renal cell carcinoma and fast-growing tumors Open
View article: Comprehensive genomic profiling can predict response to neoadjuvant chemotherapy in triple-negative breast cancer
Comprehensive genomic profiling can predict response to neoadjuvant chemotherapy in triple-negative breast cancer Open
View article: Liquid Biopsy-Based DNA Methylation Biomarkers for Precision Medicine in Breast Cancer
Liquid Biopsy-Based DNA Methylation Biomarkers for Precision Medicine in Breast Cancer Open
Background Current breast cancer (BC) diagnostics include detailed pathological and genetic analysis for biological subtype identification; however, throughout the course of the disease, new alterations determining the progression of the d…
View article: Gut Microbiome Changes After Neoadjuvant Chemotherapy and Surgery in Patients with Gastric Cancer
Gut Microbiome Changes After Neoadjuvant Chemotherapy and Surgery in Patients with Gastric Cancer Open
Background/Objectives: Neoadjuvant chemotherapy (NAC) followed by radical gastrectomy is the current standard approach for locally advanced gastric cancer (GC) in the West. Both NAC and gastrectomy can significantly influence the gut micro…
View article: Cellular and Microbial In Vitro Modelling of Gastrointestinal Cancer
Cellular and Microbial In Vitro Modelling of Gastrointestinal Cancer Open
Human diseases are multifaceted, starting with alterations at the cellular level, damaging organs and their functions, and disturbing interactions and immune responses. In vitro systems offer clarity and standardisation, which are crucial …
View article: Impact of mechanical bowel preparation on the gut microbiome of patients undergoing left-sided colorectal cancer surgery: randomized clinical trial
Impact of mechanical bowel preparation on the gut microbiome of patients undergoing left-sided colorectal cancer surgery: randomized clinical trial Open
Background Postoperative complications after colorectal cancer surgery have been linked to the gut microbiome. However, the impact of mechanical bowel preparation using oral preparation agents or rectal enema on postoperative infections re…
View article: Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals a tumor-associated endothelial tip cell phenotype
Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals a tumor-associated endothelial tip cell phenotype Open
View article: Geographic variation of mutagenic exposures in kidney cancer genomes
Geographic variation of mutagenic exposures in kidney cancer genomes Open
International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not yet been identified by conventional epidemiology make a substantial contribution to cancer burden 1 . In clear cel…
View article: Harnessing ctDNA in Advanced Melanoma: A Promising Tool for Informed Clinical Decisions
Harnessing ctDNA in Advanced Melanoma: A Promising Tool for Informed Clinical Decisions Open
Cutaneous melanoma, an aggressive malignancy, has undergone significant transformation in clinical management with the introduction of immune checkpoint inhibitors (ICIs) and targeted therapies. Current monitoring methods, such as imaging …
View article: Comprehensive Genomic Profiling Can Predict Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
Comprehensive Genomic Profiling Can Predict Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Open
View article: Germline DNA Damage Response Gene Mutations in Localized Prostate Cancer
Germline DNA Damage Response Gene Mutations in Localized Prostate Cancer Open
Background and Objectives: Germline DNA damage response (DDR) gene mutations correlate with increased prostate cancer (PCa) risk and a more aggressive form of the disease. DDR mutation testing is recommended for metastatic PCa cases, while…
View article: Combination of DNA methylation biomarkers with multiparametric magnetic resonance and ultrasound imaging fusion biopsy to detect the local spread of prostate cancer
Combination of DNA methylation biomarkers with multiparametric magnetic resonance and ultrasound imaging fusion biopsy to detect the local spread of prostate cancer Open
Background This study aimed to investigate the extent of field cancerization adjacent to index lesions in prostate cancer (PCa) by measuring DNA methylation of selected tumor suppressor genes in the perifocal tissue of PCa not visible on m…
View article: Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals an invasive tumor vasculature phenotype
Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals an invasive tumor vasculature phenotype Open
Clear cell renal cell carcinoma (ccRCC) is the most prevalent form of renal cancer, accounting for over 75% of cases. The asymptomatic nature of the disease contributes to late-stage diagnoses and poor survival. Highly vascularized and imm…
View article: Gingival Tissue MiRNA Expression Profiling and an Analysis of Periodontitis-Specific Circulating MiRNAs
Gingival Tissue MiRNA Expression Profiling and an Analysis of Periodontitis-Specific Circulating MiRNAs Open
This study aimed to identify the microRNAs (miRNAs) associated with periodontitis (PD) in gingival tissues, and to evaluate the levels of these selected miRNAs in the saliva and blood plasma among participants with and without rheumatoid a…
View article: Geographic variation of mutagenic exposures in kidney cancer genomes
Geographic variation of mutagenic exposures in kidney cancer genomes Open
International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not been identified by conventional epidemiology yet potentially make a substantial contribution to cancer burden 1 . …
View article: Synchronous endometrial and ovarian cancer: A case report
Synchronous endometrial and ovarian cancer: A case report Open
Accurate diagnosis of SEOC is essential for disease management and gene mutation analysis can be helpful as a complementary diagnostic and prognostic tool.
View article: SARS-CoV-2 RT-qPCR Ct values in saliva and nasopharyngeal swab samples for disease severity prediction
SARS-CoV-2 RT-qPCR Ct values in saliva and nasopharyngeal swab samples for disease severity prediction Open
Background Comparison of clinical value of RT-qPCR-based SARS-CoV-2 tests performed on saliva samples (SSs) and nasopharyngeal swab samples (NPSs) for prediction of the COVID-19 disease severity.Methods Three paired SSs and NPSs collected …
View article: Surveillance of cfDNA Hot Spot Mutations in NSCLC Patients during Disease Progression
Surveillance of cfDNA Hot Spot Mutations in NSCLC Patients during Disease Progression Open
Non-small cell cancer (NSCLC) has been identified with a great variation of mutations that can be surveyed during disease progression. The aim of the study was to identify and monitor lung cancer-specific mutations incidence in cell-free D…
View article: Fusion sequencing via terminator‐assisted synthesis (<scp>FTAS</scp>‐seq) identifies <i>TMPRSS2</i> fusion partners in prostate cancer
Fusion sequencing via terminator‐assisted synthesis (<span>FTAS</span>‐seq) identifies <i>TMPRSS2</i> fusion partners in prostate cancer Open
Genetic rearrangements that fuse an androgen‐regulated promoter area with a protein‐coding portion of an originally androgen‐unaffected gene are frequent in prostate cancer, with the fusion between transmembrane serine protease 2 ( TMPRSS2…
View article: ARID1A, NOTCH and WNT Signature in Gynaecological Tumours
ARID1A, NOTCH and WNT Signature in Gynaecological Tumours Open
Ovarian cancer (OC) is among the deadliest gynaecologic malignancies in the world. The majority of OC patients are diagnosed at an advanced stage, with high-grade serous OC (HGSOC). The lack of specific symptoms and suitable screening stra…
View article: Urinary DNA as a Tool for Germline and Somatic Mutation Detection in Castration-Resistant Prostate Cancer Patients
Urinary DNA as a Tool for Germline and Somatic Mutation Detection in Castration-Resistant Prostate Cancer Patients Open
(1) Background: DNA damage response (DDR) pathway gene mutations are detectable in a significant number of patients with metastatic castration-resistant prostate cancer (mCRPC). The study aimed at identification of germline and/or somatic …
View article: Changes of Colorectal Cancer Diagnostics and Hospitalizations during First Wave of COVID-19 Pandemic in Lithuania
Changes of Colorectal Cancer Diagnostics and Hospitalizations during First Wave of COVID-19 Pandemic in Lithuania Open
Purpose: Our aim was to see the possible effect of the first COVID pandemic wave in Lithuania on colorectal cancer (CRC) preventive, diagnostic and treatment procedures.Methods: A retrospective analysis was performed using the database of …
View article: Uterine Cavity Lavage Mutation Analysis in Lithuanian Ovarian Cancer Patients
Uterine Cavity Lavage Mutation Analysis in Lithuanian Ovarian Cancer Patients Open
Background: Type II ovarian cancer (OC) is generally diagnosed at an advanced stage, translating into a poor survival rate. Current screening methods for OC have failed to demonstrate a reduction in mortality. The uterine lavage technique …
View article: Urine Molecular Biomarkers for Detection and Follow-Up of Small Renal Masses
Urine Molecular Biomarkers for Detection and Follow-Up of Small Renal Masses Open
Active surveillance (AS) is the best strategy for small renal masses (SRMs) management; however, reliable methods for early detection and disease aggressiveness prediction are urgently needed. The aim of the present study was to validate D…
View article: Analysis of Intrinsic Breast Cancer Subtypes: The Clinical Utility of Epigenetic Biomarkers and TP53 Mutation Status in Triple-Negative Cases
Analysis of Intrinsic Breast Cancer Subtypes: The Clinical Utility of Epigenetic Biomarkers and TP53 Mutation Status in Triple-Negative Cases Open
This study aimed at analyzing the DNA methylation pattern and TP53 mutation status of intrinsic breast cancer (BC) subtypes for improved characterization and survival prediction. DNA methylation of 17 genes was tested by methylation-specif…
View article: The Emerging Role of Chromatin Remodeling Complexes in Ovarian Cancer
The Emerging Role of Chromatin Remodeling Complexes in Ovarian Cancer Open
Ovarian cancer (OC) is the fifth leading cause of women’s death from cancers. The high mortality rate is attributed to the late presence of the disease and the lack of modern diagnostic tools, including molecular biomarkers. Moreover, OC i…
View article: Multiparametric MRI Fusion-Guided Prostate Biopsy for Detection of Clinically Significant Prostate Cancer Eliminates the Systemic Prostate Biopsy
Multiparametric MRI Fusion-Guided Prostate Biopsy for Detection of Clinically Significant Prostate Cancer Eliminates the Systemic Prostate Biopsy Open
The primary objective of this study was to demonstrate the high accuracy of multiparametric magnetic resonance imaging and ultrasound fusion (mpMRI/US)-guided targeted prostate biopsy for the detection of clinically significant prostate ca…
View article: 69P Novel urinary methylated DNA biomarkers for kidney cancer detection and prognosis
69P Novel urinary methylated DNA biomarkers for kidney cancer detection and prognosis Open
View article: Sunitinib in patients with favorable and intermediate risk metastatic renal cell carcinoma – Lithuanian National Cancer Institute experience
Sunitinib in patients with favorable and intermediate risk metastatic renal cell carcinoma – Lithuanian National Cancer Institute experience Open
Introduction and Objectives Sunitinib, according to the European Society for Medical Oncology (ESMO) and National Comprehensive Cancer Network (NCCN) recommendations, is one of the recommended regimens for favorable and intermediate risk m…