Abstract BACKGROUND Utilizing fungicides to protect crops from diseases is an effective method, and novel eco‐friendly plant‐derived fungicides with high efficiency and low toxicity are urgent requirements for sustainable crop protection. RESULT Two series of rosin‐based fungicides (totally 35) were designed and synthesized. In vitro fungicidal activity revealed that Compound 6a (Co. 6a) effectively inhibited the growth of Valsa mali [median effective concentration (EC 50 ) = 0.627 μg mL −1 ], and in vivo fungicid…

Turpentine is a renewable and resourceful forest product. The deep processing and utilization of turpentine, particularly its primary component <i>β</i>-pinene, has garnered widespread attention. This study aimed to synthesize 40 derivatives of <i>β</i>-pinene, including nopinone, 3-cyanopyridines of nopinone, myrtanyl acid, myrtanyl acylthioureas, and myrtanyl amides. We assessed the antiviral activities of these <i>β</i>-pinene derivatives against influenza virus A/Puerto Rico/8/34 (H1N1) using the 3-(4,5-dimety…

The preparation of bioactive derivatives from the renewable natural product pinene is a hot research topic in the deep processing and utilization of pinene. In this study, β-pinene was used to develop novel molecules as a promising new precursor of insecticide. A series of amide-containing derivatives of β-pinene were synthesized and characterized. The insecticidal activities of these derivatives against Mythimna separate and Semiaphis heraclei were tested. The structure characterization results showed that the ch…

Abstract BACKGROUND The use of fungicides to protect crops from diseases is an effective method, and novel environmentally friendly plant‐derived fungicides with enhanced performance and low toxicity are urgent requirements for sustainable agriculture. RESULTS Two kinds of rosin‐based acylhydrazone compounds were designed and prepared. Based on the antifungal activity assessment against Rhizoctonia solani , Fusarium oxysporum , Phytophthora capsici , Sclerotinia sclerotiorum , and Botrytis cinerea , acylhydrazone …

Background: The development of new antifungal agents has always been a hot research topic in pesticide development. In this study, a series of derivatives of natural compound β-pinene were prepared, and the antifungal activities of these derivatives were evaluated. The purpose of this work is to develop some novel molecules as promising new fungicides. Methods: Through a variety of chemical reactions, β-pinene was transformed into a series of β-pinene-based derivatives containing amide moieties and acylthiourea mo…