Songwei Huan
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View article: Targeted Inhibition of CD74 <sup>+</sup> Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression
Targeted Inhibition of CD74 <sup>+</sup> Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression Open
Synovial inflammation represents a hallmark pathological process in osteoarthritis (OA), yet the cellular drivers orchestrating this response remain incompletely defined. Through single‐cell transcriptomic profiling of human OA synovial ti…
View article: Patient Outcomes of Thumb Arthroplasty Using a Hybrid Technique for Severe Osteoarthritis
Patient Outcomes of Thumb Arthroplasty Using a Hybrid Technique for Severe Osteoarthritis Open
Background: Patient-based evaluations effectively quantify a patient’s perception of the impact of a disorder and surgical results. With multiple surgical techniques for thumb carpometacarpal (CMC) arthritis, we propose a hybrid technique …
View article: Effectiveness of Total Hip Arthroplasty Combined With Hip Braces for Hip Charcot Arthropathy
Effectiveness of Total Hip Arthroplasty Combined With Hip Braces for Hip Charcot Arthropathy Open
Objective Charcot arthropathy is characterized by varying degrees of sensory loss and rapidly progressive joint destruction. Historically, limited studies indicated that Charcot arthropathy of the hip joint may be a contraindication for to…
View article: Dual-Targeting of PDPN-Expressing Synovial Fibroblasts and Macrophages via CLEC-2-Engineered Exosomes for Osteoarthritis Therapy
Dual-Targeting of PDPN-Expressing Synovial Fibroblasts and Macrophages via CLEC-2-Engineered Exosomes for Osteoarthritis Therapy Open
Synovitis is often associated with osteoarthritis (OA) and may even precede the onset of OA symptoms. Although targeting synovial inflammation has shown therapeutic promise in OA, the synovium's heterogeneous composition, with multiple cel…
View article: Total hip arthroplasty after pelvic osteotomy: a meta-analysis
Total hip arthroplasty after pelvic osteotomy: a meta-analysis Open
Several studies suggested that total hip arthroplasty (THA) was more technical demanding following previous pelvic osteotomy (PO), resulting in poor outcomes compared with primary THA. However, the other studies regarding this topic had re…
View article: The impact of China’s healthcare reforms on promoting early treatment for femoral neck fractures
The impact of China’s healthcare reforms on promoting early treatment for femoral neck fractures Open
Gan, Wenyi MD; Zhuang, Tengfeng MD; Lu, Chongxuan MD; Xiong, Minying MD; Huan, Songwei MD Author Information
View article: A systematic review on the cost‐effectiveness of the computer‐assisted orthopedic system
A systematic review on the cost‐effectiveness of the computer‐assisted orthopedic system Open
Computer‐assisted orthopedic system (CAOS) is rapidly gaining popularity in the field of precision medicine. However, the cost‐effectiveness of CAOS has not been well clarified. We performed this review to summarize and assess the cost‐eff…
View article: Survivorship of the retained femoral component after revision total hip arthroplasty: A systematic review and meta-analysis
Survivorship of the retained femoral component after revision total hip arthroplasty: A systematic review and meta-analysis Open
Objective This systematic review and meta-analysis aimed to estimate re-revision rates of retained femoral components after revision of total hip arthroplasty (THA). Methods Papers were searched in the PubMed, Embase, Web of Science, and C…
View article: Senescent skeletal cells cross-talk with synovial cells plays a key role in the pathogenesis of osteoarthritis
Senescent skeletal cells cross-talk with synovial cells plays a key role in the pathogenesis of osteoarthritis Open
Osteoarthritis (OA) has been recognized as an age-related degenerative disease commonly seen in the elderly that affects the whole “organ” including cartilage, subchondral bone, synovium, and muscles. An increasing number of studies have s…
View article: The role of routine postoperative laboratory tests following hip hemiarthroplasty for an elderly femoral neck fracture
The role of routine postoperative laboratory tests following hip hemiarthroplasty for an elderly femoral neck fracture Open
Background Performing postoperative laboratory tests following joint arthroplasty is a regular practice. However, the role of routine postoperative laboratory tests in primary hip arthroplasty is currently in doubt. This study aimed to ass…
View article: Long Noncoding RNA KCNQ1OT1 is a Prognostic Biomarker and mediates CD8<sup>+</sup> T cell exhaustion by regulating CD155 Expression in Colorectal Cancer
Long Noncoding RNA KCNQ1OT1 is a Prognostic Biomarker and mediates CD8<sup>+</sup> T cell exhaustion by regulating CD155 Expression in Colorectal Cancer Open
Background: Long noncoding RNA KCNQ1 opposite strand/antisense transcript 1 (lncRNA KCNQ1OT1) is abnormally expressed in various solid tumors. The purpose of this study was to explore the prognostic value and potential functional role of l…
View article: <p>Combination BET Family Protein and HDAC Inhibition Synergistically Elicits Chondrosarcoma Cell Apoptosis Through RAD51-Related DNA Damage Repair</p>
Combination BET Family Protein and HDAC Inhibition Synergistically Elicits Chondrosarcoma Cell Apoptosis Through RAD51-Related DNA Damage Repair Open
Taken together, our results disclose that BET and HDAC inhibition synergistically inhibit cell growth and induce cell apoptosis through a mechanism that involves the suppression of RAD51-related HR DNA repair in chondrosarcoma cells.
View article: Analysis of Access to Medical Information of Residents of Different Ages in Guangzhou
Analysis of Access to Medical Information of Residents of Different Ages in Guangzhou Open
We conducted a field investigation of 803 residents in Guangzhou through a self-designed questionnaire to analyze the ways in which residents of different ages obtained medical information and the differences in trust in medical informatio…