Sónia Castanheira
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View article: A global view of morphogenetic peptidoglycan synthases across the domain Bacteria
A global view of morphogenetic peptidoglycan synthases across the domain Bacteria Open
Bacteria define their heritable cell shape using membrane integral glycosyltransferases (GTases) of the shape, elongation, division, and sporulation protein family and monofunctional D, D-transpeptidases of the class B penicillin-binding p…
View article: Morphogenetic penicillin-binding proteins control virulence-associated type III secretion systems in <i>Salmonella</i>
Morphogenetic penicillin-binding proteins control virulence-associated type III secretion systems in <i>Salmonella</i> Open
Type III protein secretion systems (T3SSs) function as multiprotein devices that span the envelope of Gram-negative bacteria using the peptidoglycan (PG) layer as scaffold. This spatial arrangement explains why modifications in PG structur…
View article: In Vivo Cross‐Linking Sheds Light on the <i>Salmonella</i> Divisome in Which <scp>PBP3</scp> and <scp>PBP3<sub>SAL</sub></scp> Compete for Occupancy
In Vivo Cross‐Linking Sheds Light on the <i>Salmonella</i> Divisome in Which <span>PBP3</span> and <span>PBP3<sub>SAL</sub></span> Compete for Occupancy Open
Bacterial cell division is orchestrated by proteins that assemble in dynamic complexes collectively known as the divisome. Essential monofunctional enzymes with glycosyltransferase or transpeptidase (TPase) activities, FtsW and FtsI respec…
View article: Evidence of two differentially regulated elongasomes in Salmonella
Evidence of two differentially regulated elongasomes in Salmonella Open
Cell shape is genetically inherited by all forms of life. Some unicellular microbes increase niche adaptation altering shape whereas most show invariant morphology. A universal system of peptidoglycan synthases guided by cytoskeletal scaff…
View article: Affinity of cefotiam for the alternative penicillin binding protein PBP3SAL used by <i>Salmonella</i> inside host eukaryotic cells
Affinity of cefotiam for the alternative penicillin binding protein PBP3SAL used by <i>Salmonella</i> inside host eukaryotic cells Open
Background Following the invasion of eukaryotic cells, Salmonella enterica serovar Typhimurium replaces PBP2/PBP3, main targets of β-lactam antibiotics, with PBP2SAL/PBP3SAL, two homologue peptidoglycan synthases absent in Escherichia coli…
View article: <scp>OmpR</scp> and Prc contribute to switch the <i>Salmonella</i> morphogenetic program in response to phagosome cues
<span>OmpR</span> and Prc contribute to switch the <i>Salmonella</i> morphogenetic program in response to phagosome cues Open
Salmonella enterica serovar Typhimurium infects eukaryotic cells residing within membrane‐bound phagosomes. In this compartment, the pathogen replaces the morphogenetic penicillin‐binding proteins 2 and 3 (PBP2/PBP3) with PBP2 SAL /PBP3 SA…
View article: Peptidoglycan editing in non-proliferating intracellular Salmonella as source of interference with immune signaling
Peptidoglycan editing in non-proliferating intracellular Salmonella as source of interference with immune signaling Open
Salmonella enterica causes intracellular infections that can be limited to the intestine or spread to deeper tissues. In most cases, intracellular bacteria show moderate growth. How these bacteria face host defenses that recognize peptidog…
View article: <i>Salmonella</i> exploits OmpR to switch essential morphogenetic peptidoglycan synthases in response to intracellular cues
<i>Salmonella</i> exploits OmpR to switch essential morphogenetic peptidoglycan synthases in response to intracellular cues Open
Essential peptidoglycan synthases, like penicillin binding proteins 2 and 3 (PBP2/PBP3) of Escherichia coli , define shape by orchestrating cell elongation and division, respectively. Despite being intensively studied as drug targets, the …
View article: A Novel Salmonella Periplasmic Protein Controlling Cell Wall Homeostasis and Virulence
A Novel Salmonella Periplasmic Protein Controlling Cell Wall Homeostasis and Virulence Open
Horizontal gene transfer has shaped the evolution of Salmonella enterica as pathogen. Some functions acquired by this mechanism include enzymes involved in peptidoglycan (PG) synthesis and remodeling. Here, we report a novel serovar Typhim…
View article: Incompatibility between proliferation and plant invasion is mediated by a regulator of appressorium formation in the corn smut fungus <i>Ustilago maydis</i>
Incompatibility between proliferation and plant invasion is mediated by a regulator of appressorium formation in the corn smut fungus <i>Ustilago maydis</i> Open
Significance Many phytopathogenic fungi need specialized structures, called appressoria, to penetrate the plant before infection starts. For these structures, the fungus must carefully control when and where its cells divide, and it has be…
View article: Cytoplasmic retention and degradation of a mitotic inducer enable plant infection by a pathogenic fungus
Cytoplasmic retention and degradation of a mitotic inducer enable plant infection by a pathogenic fungus Open
In the fungus Ustilago maydis, sexual pheromones elicit mating resulting in an infective filament able to infect corn plants. Along this process a G2 cell cycle arrest is mandatory. Such as cell cycle arrest is initiated upon the pheromone…
View article: Two distinct penicillin binding proteins promote cell division in different Salmonella lifestyles
Two distinct penicillin binding proteins promote cell division in different Salmonella lifestyles Open
The bacterial cell wall preserves cell integrity in response to external insults and the internal turgor pressure. The major component of the cell wall is the peptidoglycan (PG); a giant macromolecule formed by glycan chains cross-linked b…
View article: A Specialized Peptidoglycan Synthase Promotes <i>Salmonella</i> Cell Division inside Host Cells
A Specialized Peptidoglycan Synthase Promotes <i>Salmonella</i> Cell Division inside Host Cells Open
Bacterial cell division has been studied extensively under laboratory conditions. Despite being a key event in the bacterial cell cycle, cell division has not been explored in vivo in bacterial pathogens interacting with their hosts. We di…
View article: Salmonella Populations inside Host Cells
Salmonella Populations inside Host Cells Open
Bacteria of the Salmonella genus cause diseases ranging from gastroenteritis to life-threatening typhoid fever and are among the most successful intracellular pathogens known. After the invasion of the eukaryotic cell, Salmonella exhibits …