Sonia Jangra
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View article: Th2 immune responses promote anti-viral and anti-inflammatory activity during mild COVID-19 9405
Th2 immune responses promote anti-viral and anti-inflammatory activity during mild COVID-19 9405 Open
Description SARS-CoV-2 infected individuals frequently develop mild disease; however, the underlying mechanisms of improved outcomes are unknown. Using a training cohort, integrated clinical and molecular parameters revealed signatures tha…
View article: Dose-dependent interferon programs in myeloid cells after mRNA and adenovirus COVID-19 vaccination
Dose-dependent interferon programs in myeloid cells after mRNA and adenovirus COVID-19 vaccination Open
The SARS-CoV-2 pandemic provided a rare opportunity to study how human immune responses develop to a novel viral antigen delivered through different vaccine platforms. However, to date, no study has directly compared immune responses to al…
View article: Identification and targeting of regulators of SARS-CoV-2–host interactions in the airway epithelium
Identification and targeting of regulators of SARS-CoV-2–host interactions in the airway epithelium Open
The impact of SARS-CoV-2 in the lung has been extensively studied, yet the molecular regulators of host-cell programs hijacked by the virus in distinct human airway epithelial cell populations remain poorly understood. Some of the reasons …
View article: Identification and Targeting of Regulators of SARS-CoV-2-Host Interactions in the Airway Epithelium.
Identification and Targeting of Regulators of SARS-CoV-2-Host Interactions in the Airway Epithelium. Open
Background In spite of the wealth of literature available, the mechanistic determinants of SARS-CoV-2-mediated host-cell hijacking that results in massive infection of the human airway epithelium are still poorly understood. While ciliated…
View article: Sequential immunization with chimeric hemagglutinin ΔNS1 attenuated influenza vaccines induces broad humoral and cellular immunity
Sequential immunization with chimeric hemagglutinin ΔNS1 attenuated influenza vaccines induces broad humoral and cellular immunity Open
Here, the investigators compared two different universal influenza vaccine platforms that use the format of an intranasally administered LAIV.
View article: Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in quadrivalent influenza vaccine vaccinated mice
Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in quadrivalent influenza vaccine vaccinated mice Open
There are considerable avenues through which currently licensed influenza vaccines could be optimized. We tested influenza vaccination in a mouse model with two adjuvants: Sendai virus-derived defective interfering (SDI) RNA, a RIG-I agoni…
View article: Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in QIV vaccinated mice
Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in QIV vaccinated mice Open
Adjuvants can enhance vaccine effectiveness of currently licensed influenza vaccines. We tested influenza vaccination in a mouse model with two adjuvants: Sendai virus derived defective interfering (SDI) RNA, a RIG-I agonist, and an amphip…
View article: Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian hamsters
Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian hamsters Open
Hybrid immunity (vaccination + natural infection) to SARS-CoV-2 provides superior protection to re-infection. We performed immune profiling studies during breakthrough infections in mRNA-vaccinated hamsters to evaluate hybrid immunity indu…
View article: Protocol for establishing primary human lung organoid-derived air-liquid interface cultures from cryopreserved human lung tissue
Protocol for establishing primary human lung organoid-derived air-liquid interface cultures from cryopreserved human lung tissue Open
View article: Lipid Nanoparticle Encapsulation Empowers Poly(I:C) to Activate Cytoplasmic RLRs and Thereby Increases Its Adjuvanticity
Lipid Nanoparticle Encapsulation Empowers Poly(I:C) to Activate Cytoplasmic RLRs and Thereby Increases Its Adjuvanticity Open
Poly(I:C) is a synthetic analogue of dsRNA capable of activating both TLR3 and RLRs, such as MDA‐5 and RIG‐I, as pathogen recognition receptors. While poly(I:C) is known to provoke a robust type I IFN, type III IFN, and Th1 cytokine respon…
View article: SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels
SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels Open
Patients with coronavirus disease 2019 (COVID-19) present increased risk for ischemic cardiovascular complications up to 1 year after infection. Although the systemic inflammatory response to severe acute respiratory syndrome coronavirus 2…
View article: Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis Open
To assess the role of ORF6, and its recently emerged variant polymorphisms, on the host response to SARS-CoV-2 during infection using ORF6 mutant recombinant viruses.
View article: Protocol for primary human lung organoid-derived air-liquid interface<i>in vitro</i>model to study response to SARS-CoV-2
Protocol for primary human lung organoid-derived air-liquid interface<i>in vitro</i>model to study response to SARS-CoV-2 Open
Summary This article presents a comprehensive protocol for establishing primary human lung organoid-derived air-liquid interface (ALI) cultures from cryopreserved human lung tissue. These cultures serve as a physiologically relevant model …
View article: SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels
SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels Open
COVID-19 patients present higher risk for myocardial infarction (MI), acute coronary syndrome, and stroke for up to 1 year after SARS-CoV-2 infection. While the systemic inflammatory response to SARS-CoV-2 infection likely contributes to t…
View article: Influenza breakthrough infection in vaccinated mice is characterized by non-pathological lung eosinophilia
Influenza breakthrough infection in vaccinated mice is characterized by non-pathological lung eosinophilia Open
Eosinophils are important mediators of mucosal tissue homeostasis, anti-helminth responses, and allergy. Lung eosinophilia has previously been linked to aberrant Type 2-skewed T cell responses to respiratory viral infection and may also be…
View article: Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia
Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia Open
View article: Multicomponent intranasal adjuvant for mucosal and durable systemic SARS-CoV-2 immunity in young and aged mice
Multicomponent intranasal adjuvant for mucosal and durable systemic SARS-CoV-2 immunity in young and aged mice Open
View article: Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian Hamsters
Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian Hamsters Open
Hybrid immunity to SARS-CoV-2 provides superior protection to re-infection. We performed immune profiling studies during breakthrough infections in mRNA-vaccinated hamsters to evaluate hybrid immunity induction. mRNA vaccine, BNT162b2, was…
View article: Characterization of Lung Eosinophil Subsets During Respiratory Viral Infection in Mice with Pre-Existing Immunity
Characterization of Lung Eosinophil Subsets During Respiratory Viral Infection in Mice with Pre-Existing Immunity Open
Eosinophils are critical cells in Type 2 immune responses and mucosal tissue homeostasis. Historically, lung eosinophilia has been linked to aberrant Th2 responses in response to inhaled allergens or as a consequence of vaccine-associated …
View article: SARS-CoV-2 Ancestral and Variant of Concern Breakthrough infections boost both cross-reactive cellular and humoral immune responses in mRNA-vaccinated Hamsters
SARS-CoV-2 Ancestral and Variant of Concern Breakthrough infections boost both cross-reactive cellular and humoral immune responses in mRNA-vaccinated Hamsters Open
When mRNA vaccines were rolled out under EUA, it was observed that a single vaccination, already protected vaccinees from severe disease, even before neutralizing antibodies appearded. To better understand the underlying mechanism of prote…
View article: A rationally designed combined intranasal adjuvant drives robust and broad humoral, cellular, and mucosal immune responses to SARS-CoV-2
A rationally designed combined intranasal adjuvant drives robust and broad humoral, cellular, and mucosal immune responses to SARS-CoV-2 Open
Multiple FDA-approved SARS-CoV-2 vaccines have provided excellent protection against severe disease. Despite this, immunity can wane relatively fast, particularly in the elderly and novel viral variants capable of evading infection- and va…
View article: Adjuvant skewing of host immune response to vaccination and subsequent infection with influenza virus
Adjuvant skewing of host immune response to vaccination and subsequent infection with influenza virus Open
Despite being a vaccine-preventable disease, seasonal influenza is responsible for thousands of hospitalizations and deaths yearly. Currently licensed quadrivalent inactivated influenza virus vaccines (QIV) aim to induce neutralizing antib…
View article: Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia
Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia Open
The COVID-19 pandemic continues to be a health crisis with major unmet medical needs. The early responses from airway epithelial cells, the first target of the virus regulating the progression towards severe disease, are not fully understo…
View article: Suppression of cGAS- and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1
Suppression of cGAS- and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1 Open
Epstein-Barr virus (EBV) has developed effective strategies to evade host innate immune responses. Here we reported on mitigation of type I interferon (IFN) production by EBV deubiquitinase (DUB) BPLF1 through cGAS-STING and RIG-I-MAVS pat…
View article: A multicomponent intranasal adjuvant drives durable humoral, cellular, and mucosal immune responses to SARS-CoV-2 in young and aged mice.
A multicomponent intranasal adjuvant drives durable humoral, cellular, and mucosal immune responses to SARS-CoV-2 in young and aged mice. Open
View article: RIG-I and TLR-7/8 agonists as combination adjuvant shapes unique antibody and cellular vaccine responses to seasonal influenza vaccine
RIG-I and TLR-7/8 agonists as combination adjuvant shapes unique antibody and cellular vaccine responses to seasonal influenza vaccine Open
Influenza vaccine effectiveness could be improved by combination with an adjuvant with the potential to enhance the host-vaccine response both quantitatively and qualitatively. The goal of this study was to explore a RIG-I agonist (SDI-nan…
View article: Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis Open
We and others have previously shown that the SARS-CoV-2 accessory protein ORF6 is a powerful antagonist of the interferon (IFN) signaling pathway by directly interacting with Nup98-Rae1 at the nuclear pore complex (NPC) and disrupting bidi…
View article: Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariants
Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariants Open
View article: Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera
Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera Open
View article: RIG-I and TLR-7/8 agonists as combination adjuvant shape unique antibody and cellular vaccine responses to seasonal influenza vaccine
RIG-I and TLR-7/8 agonists as combination adjuvant shape unique antibody and cellular vaccine responses to seasonal influenza vaccine Open
Influenza vaccine effectiveness could be improved by combination with an adjuvant with the potential to enhance the host-vaccine response both quantitatively and qualitatively. The goal of this study was to explore a RIG-I agonist (SDI-nan…