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View article: Preventing resistance development in infections by OXA β-lactamase-producing <i>Pseudomonas aeruginosa</i> : correlating clinical outcomes with hollow-fibre model input
Preventing resistance development in infections by OXA β-lactamase-producing <i>Pseudomonas aeruginosa</i> : correlating clinical outcomes with hollow-fibre model input Open
Background Infections caused by XDR Pseudomonas aeruginosa significantly limit treatment options. Although ceftolozane/tazobactam and ceftazidime/avibactam have emerged as promising alternatives, increasing resistance has been reported. Th…
View article: An easy-to-use predictive score for identifying patients at risk of suboptimal linezolid exposure and candidates for therapeutic drug monitoring
An easy-to-use predictive score for identifying patients at risk of suboptimal linezolid exposure and candidates for therapeutic drug monitoring Open
The predictive score provides clinicians with an effective tool to support individualised linezolid therapy and guide TDM implementation, reducing the risk of toxicity or treatment failure.
View article: Estimating the Value of Aztreonam-Avibactam in Treating Metallo-beta-Lactamase-Producing Enterobacterales Infections in Spain Using the STEDI AMR Value Framework
Estimating the Value of Aztreonam-Avibactam in Treating Metallo-beta-Lactamase-Producing Enterobacterales Infections in Spain Using the STEDI AMR Value Framework Open
In Spain, ATM-AVI is a highly cost-effective and urgently needed treatment option for patients with MBL-EB including HAP/VAP and cIAI infections. Using the novel STEDI framework unlocks the considerable value of a new antibiotic which is e…
View article: Therapeutic Drug Monitoring of Amikacin and Colistin in Patients with Multidrug-Resistant Gram-Negative Infections Using a Portable Plasmonic Biosensor
Therapeutic Drug Monitoring of Amikacin and Colistin in Patients with Multidrug-Resistant Gram-Negative Infections Using a Portable Plasmonic Biosensor Open
Innovative diagnostic tools that enhance antibiotic routine monitoring can improve the management of infections caused by antibiotic-resistant bacteria. Therapeutic drug monitoring (TDM) involves measuring drug levels in the patient bloods…
View article: Thick-Billed Murres <i>Uria lomvia</i> at Cape Parry, Northwest Territories: Core-use Areas, Morphometrics and Chick Diets
Thick-Billed Murres <i>Uria lomvia</i> at Cape Parry, Northwest Territories: Core-use Areas, Morphometrics and Chick Diets Open
Cape Parry is home to the only colony of Thick-billed Murres Uria lomvia in the western Canadian Arctic, but ecological information for this small, isolated population is lacking. To address this information gap, we investigated the spatia…
View article: Thick-Billed Murres <i>Uria lomvia</i> at Cape Parry, Northwest Territories: Core-use Areas, Morphometrics and Chick Diets
Thick-Billed Murres <i>Uria lomvia</i> at Cape Parry, Northwest Territories: Core-use Areas, Morphometrics and Chick Diets Open
Cape Parry is home to the only colony of Thick-billed Murres Uria lomvia in the western Canadian Arctic, but ecological information for this small, isolated population is lacking. To address this information gap, we investigated the spatia…
View article: Gram-positive infections in special populations. Expert view on the role of dalbavancin
Gram-positive infections in special populations. Expert view on the role of dalbavancin Open
Dalbavancin may be a valid alternative to overcome the difficulties of infection management in these populations. We hope our insights will prove useful for patient-centered care. A long half-life, evidence-based efficacy and good safety p…
View article: Pharmacodynamic interaction of apotransferrin and anti-pseudomonal antibiotics against extensively drug-resistant Pseudomonas aeruginosa in a dynamic PK/PD model
Pharmacodynamic interaction of apotransferrin and anti-pseudomonal antibiotics against extensively drug-resistant Pseudomonas aeruginosa in a dynamic PK/PD model Open
In conclusion, the combination of apotransferrin with C/T demonstrated superior in vitro efficacy against XDR P. aeruginosa isolates compared to either treatment alone. These findings suggest that apotransferrin could be a valuable adjunct…
View article: Economic impact of individualized antimicrobial dose optimization in the critically ill patient in Spain
Economic impact of individualized antimicrobial dose optimization in the critically ill patient in Spain Open
Objective To estimate the economic impact of individualized dose optimization guided by antimicrobial therapeutic drug monitoring (TDM) in Spain, compared to no monitoring. Methods A cost analysis of antibiotic treatment of critically ill …
View article: Addressing carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa: the potential of cefiderocol and ceftazidime/avibactam plus aztreonam therapy
Addressing carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa: the potential of cefiderocol and ceftazidime/avibactam plus aztreonam therapy Open
This study evaluated the activity of cefiderocol and the combination of ceftazidime/avibactam (CZA) plus aztreonam against carbapenemase-producing extensively drug-resistant (XDR) Pseudomonas aeruginosa isolates. Nine clinical XDR P. aerug…
View article: [Translated article] National survey and consensus document on dosing strategies for beta-lactam antibiotics against multidrug-resistant gram-negative bacilli (MDR-GNB) in critically ill patients undergoing extracorporeal life-support techniques: The DOSEBL study protocol
[Translated article] National survey and consensus document on dosing strategies for beta-lactam antibiotics against multidrug-resistant gram-negative bacilli (MDR-GNB) in critically ill patients undergoing extracorporeal life-support techniques: The DOSEBL study protocol Open
The availability of extracorporeal life-support techniques has expanded significantly in recent years, alongside a rise in the prevalence of infections caused by MDR-GNB. There is a need to develop evidence-based tools of high quality to s…
View article: [Translated article] Therapeutic Drug Monitoring of antibiotic and antifungical drugs in paediatric and newborn patients. Consensus Guidelines of the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Paediatric Infectious Diseases (SEIP)
[Translated article] Therapeutic Drug Monitoring of antibiotic and antifungical drugs in paediatric and newborn patients. Consensus Guidelines of the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Paediatric Infectious Diseases (SEIP) Open
Therapeutic monitoring of antibiotics and antifungals based on pharmacokinetic and pharmacodynamic (PK/PD) parameters is a strategy increasingly used for the optimization of therapy to improve efficacy, reduce the occurrence of toxicities,…
View article: Therapeutic Drug Monitoring of antibiotic and antifungical drugs in paediatric and newborn patients. Consensus Guidelines of the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Paediatric Infectious Diseases (SEIP)
Therapeutic Drug Monitoring of antibiotic and antifungical drugs in paediatric and newborn patients. Consensus Guidelines of the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Paediatric Infectious Diseases (SEIP) Open
Therapeutic monitoring of antibiotics and antifungals based on pharmacokinetic and pharmacodynamic (PK/PD) parameters is a strategy increasingly used for the optimization of therapy to improve efficacy, reduce the occurrence of toxicities,…
View article: Synergistic efficacy of ceftazidime/avibactam and aztreonam against carbapenemase-producing <i>Pseudomonas aeruginosa</i> : insights from the hollow-fiber infection model
Synergistic efficacy of ceftazidime/avibactam and aztreonam against carbapenemase-producing <i>Pseudomonas aeruginosa</i> : insights from the hollow-fiber infection model Open
The combination of CZA and aztreonam significantly enhanced the in vitro efficacy against XDR P. aeruginosa isolates compared to each monotherapy. This improvement suggests that the combination could serve as a feasible treatment alternati…
View article: Stability Studies of Antipseudomonal Beta Lactam Agents for Outpatient Therapy
Stability Studies of Antipseudomonal Beta Lactam Agents for Outpatient Therapy Open
Outpatient parenteral antimicrobial therapy (OPAT) is a useful treatment strategy against Pseudomonas aeruginosa and other multidrug-resistant bacteria. However, it is hindered by the lack of stability data for the administration of antibi…
View article: Isavuconazole use and TDM in real-world pediatric practice
Isavuconazole use and TDM in real-world pediatric practice Open
Isavuconazole (ISA) is approved for treating invasive aspergillosis and mucormycosis in adults, but its use in children remains off-label. We report on the use of ISA in real-world pediatric practice with 15 patients receiving ISA for trea…
View article: Colistin plasma concentrations are not associated with better clinical outcomes in patients with pneumonia caused by extremely drug-resistant <i>Pseudomonas aeruginosa</i>
Colistin plasma concentrations are not associated with better clinical outcomes in patients with pneumonia caused by extremely drug-resistant <i>Pseudomonas aeruginosa</i> Open
The objective of this study was to examine the relationship between colistin plasma concentrations and clinical outcomes in patients with hospital-acquired pneumonia (HAP) caused by extensively drug-resistant Pseudomonas aeruginosa (XDR-PA…
View article: Real-world experience of therapeutic drug monitoring and PK/PD achievement of ceftaroline administered by different infusion regimens in patients with confirmed infections caused by Gram-positive bacteria
Real-world experience of therapeutic drug monitoring and PK/PD achievement of ceftaroline administered by different infusion regimens in patients with confirmed infections caused by Gram-positive bacteria Open
Background Ceftaroline is a novel cephalosporin active against MDR Gram-positive (GP) bacteria. For β-lactam antibiotics, such as ceftaroline, prolonged infusions and therapeutic drug monitoring (TDM) are used for dosage optimization based…
View article: Clinical, Microbiological and Treatment Characteristics of Severe Postoperative Respiratory Infections: An Observational Cohort Study
Clinical, Microbiological and Treatment Characteristics of Severe Postoperative Respiratory Infections: An Observational Cohort Study Open
Respiratory infections are frequent and life-threatening complications of surgery. This study aimed to evaluate the clinical, microbiological and treatment characteristics of severe postoperative pneumonia (POP) and tracheobronchitis (POT)…
View article: Development and Validation of a Risk Score for Predicting Non-Adherence to Antiretroviral Therapy
Development and Validation of a Risk Score for Predicting Non-Adherence to Antiretroviral Therapy Open
Several patient-related factors that influence adherence to antiretroviral therapy (ART) have been described. However, studies that propose a practical and simple tool to predict nonadherence after ART initiation are still scarce. In this …
View article: 4CPS-226 Continuous infusion of vancomicyn: who are the patient candidates and how safe it is?
4CPS-226 Continuous infusion of vancomicyn: who are the patient candidates and how safe it is? Open
Background and Importance Data about the efficacy and toxicity of vancomycin used by continuous infusion (CI) compared to intermittent infusion (II) are still controversial. Aim and Objectives To compare the profile of patients treated wit…
View article: Therapeutic Drug Monitoring of Vancomycin Concentrations for the Management of Bone and Joint Infections: An Urgent Need
Therapeutic Drug Monitoring of Vancomycin Concentrations for the Management of Bone and Joint Infections: An Urgent Need Open
Vancomycin is used for the treatment of bone and joint infections (BJI), but scarce information is available about its pharmacokinetic/pharmacodynamic (PK/PD) characteristics. We aimed to identify the risk factors associated with the non-a…
View article: Pharmacokinetics/pharmacodynamics and therapeutic drug monitoring of ceftazidime/avibactam administered by continuous infusion in patients with MDR Gram-negative bacterial infections
Pharmacokinetics/pharmacodynamics and therapeutic drug monitoring of ceftazidime/avibactam administered by continuous infusion in patients with MDR Gram-negative bacterial infections Open
Background Therapeutic drug monitoring (TDM) of β-lactams in critically ill patients has been correlated with better clinical outcomes. Evidence on TDM of newer β-lactams such as ceftazidime/avibactam administered by continuous infusion (C…
View article: Drug-related problems in patients admitted for SARS-CoV-2 infection during the COVID-19 pandemic
Drug-related problems in patients admitted for SARS-CoV-2 infection during the COVID-19 pandemic Open
Introduction: Drug-related problems (DRP) are events or circumstances in which drug therapy does or could interfere with desired health outcomes. In December 2019, a new coronavirus, SARS-CoV-2, appeared. Little knowledge about this type o…
View article: Suboptimal Concentrations of Ceftazidime/Avibactam (CAZ-AVI) May Select for CAZ-AVI Resistance in Extensively Drug-Resistant Pseudomonas aeruginosa: In Vivo and In Vitro Evidence
Suboptimal Concentrations of Ceftazidime/Avibactam (CAZ-AVI) May Select for CAZ-AVI Resistance in Extensively Drug-Resistant Pseudomonas aeruginosa: In Vivo and In Vitro Evidence Open
This study correlates in vivo findings in a patient with an extensively drug-resistant (XDR) P. aeruginosa infection who developed resistance to ceftazidime-avibactam (CAZ-AVI) with in vitro results of a 7-day hollow-fiber infection model …
View article: Comparison of Ceftolozane/Tazobactam Infusion Regimens in a Hollow-Fiber Infection Model against Extensively Drug-Resistant Pseudomonas aeruginosa Isolates
Comparison of Ceftolozane/Tazobactam Infusion Regimens in a Hollow-Fiber Infection Model against Extensively Drug-Resistant Pseudomonas aeruginosa Isolates Open
Ceftolozane-tazobactam (C/T) is an antipseudomonal antibiotic with a high clinical impact in treating infection caused by extensively drug-resistant (XDR) Pseudomonas aeruginosa isolates, but resistance is emerging. Given its time-dependen…
View article: 4CPS-243 Influence of venovenous extracorporeal membrane oxygenation on the pharmacokinetics of vancomycin in adults: can an optimal pharmacodynamic target be achieved?
4CPS-243 Influence of venovenous extracorporeal membrane oxygenation on the pharmacokinetics of vancomycin in adults: can an optimal pharmacodynamic target be achieved? Open
Background and importance Patients undergoing extracorporeal membrane oxygenation (ECMO) may present significant changes in antibiotics pharmacokinetics (PK). Aim and objectives To describe the PK of vancomycin in ECMO patients and the ach…