Sébastien Gagneux
YOU?
Author Swipe
View article: Clinical and bacterial determinants of unfavorable tuberculosis treatment outcomes: an observational study in Georgia
Clinical and bacterial determinants of unfavorable tuberculosis treatment outcomes: an observational study in Georgia Open
Background Tuberculosis (TB) remains a major public health concern. Improving TB control programs and treatment success requires a deeper understanding of the factors that determine disease presentation and treatment outcomes. While the im…
View article: Variability in intrinsic drug tolerance in <i>Mycobacterium tuberculosis</i> corresponds with phylogenetic lineage
Variability in intrinsic drug tolerance in <i>Mycobacterium tuberculosis</i> corresponds with phylogenetic lineage Open
Drug tolerance allows bacteria to survive extended exposure to bactericidal drugs and is thought to play a role in drug resistance evolution. In Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), multidrug-resistan…
View article: Mycobacterium tuberculosis complex Lineage 1: A neglected cause of tuberculosis
Mycobacterium tuberculosis complex Lineage 1: A neglected cause of tuberculosis Open
The Mycobacterium tuberculosis complex (MTBC) phylogenetic lineages 1–4 (L1–L4) are the main causes of human tuberculosis (TB). Until now, most of the focus in the TB field has been on MTBC L2 and L4, as these two lineages are geographical…
View article: Epistasis between drug resistance-conferring mutations in <i>Mycobacterium tuberculosis</i>
Epistasis between drug resistance-conferring mutations in <i>Mycobacterium tuberculosis</i> Open
Studies in model organisms show that mutations conferring resistance to different antibiotics can interact epistatically, but the biological and epidemiological consequences of such interactions are unknown. Here we show that in Mycobacter…
View article: Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania
Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania Open
Infectious diseases have affected humanity for millennia and are among the strongest selective forces. Tuberculosis (TB) is an ancient disease, caused by the human-adapted members of the Mycobacterium tuberculosis complex (MTBC). The outco…
View article: Granulysin Antimicrobial Activity Promotes Dormancy in <i>Mycobacterium tuberculosis</i>
Granulysin Antimicrobial Activity Promotes Dormancy in <i>Mycobacterium tuberculosis</i> Open
Human tuberculosis (TB) caused by Mycobacterium tuberculosis ( Mtb ) remains a global public health threat. Granulomas constitute a hallmark of TB pathogenesis that can clear, contain, or exacerbate an infection. Containment is exploited b…
View article: Within-host evolution of drug tolerance in <i>Mycobacterium tuberculosis</i>
Within-host evolution of drug tolerance in <i>Mycobacterium tuberculosis</i> Open
Synopsis Background Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB) in humans. Poor treatment responses are a threat to global TB control, as such, understanding contributing factors to poor responses is important. We hypothesize…
View article: Linking genetic and phenotypic bedaquiline resistance in Mycobacterium tuberculosis strains from Georgia
Linking genetic and phenotypic bedaquiline resistance in Mycobacterium tuberculosis strains from Georgia Open
Introduction Resistance to bedaquiline – a novel, promising medication against tuberculosis (TB), is already emerging, and uncertainties regarding the role of the different resistance-conferring mutations complicate the development of mole…
View article: Variability in intrinsic drug tolerance in <i>Mycobacterium tuberculosis</i> corresponds with phylogenetic lineage
Variability in intrinsic drug tolerance in <i>Mycobacterium tuberculosis</i> corresponds with phylogenetic lineage Open
Drug tolerance allows bacteria to survive extended exposure to bactericidal drugs and is thought to play a role in drug resistance evolution. In Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), multidrug resistan…
View article: Gene conversion and duplication contribute to genetic variation in an outbreak of Mycobacterium tuberculosis
Gene conversion and duplication contribute to genetic variation in an outbreak of Mycobacterium tuberculosis Open
Repeats are the most diverse and dynamic but also the least well-understood component of microbial genomes. For all we know, repeat-associated mutations such as duplications, deletions, inversions and gene conversion might be as common as …
View article: Mycobacteria beyond disease
Mycobacteria beyond disease Open
Mycobacteria have coevolved with humans over millennia, leaving profound imprints on our immune systems. Beyond active disease, their exposure may exert immunomodulatory effects, including allergy modulation and heterologous protection aga…
View article: Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages
Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages Open
The members of the Mycobacterium tuberculosis complex (MTBC) causing human tuberculosis comprise 10 phylogenetic lineages that differ in their geographical distribution. The human consequences of this phylogenetic diversity remain poorly u…
View article: Onset of infectiousness explains differences in transmissibility across Mycobacterium tuberculosis lineages
Onset of infectiousness explains differences in transmissibility across Mycobacterium tuberculosis lineages Open
Mycobacterium tuberculosis complex (MTBC) lineages show substantial variability in virulence, but the epidemiological consequences of this variability have not been studied in detail. Here, we aimed for a lineage-specific epidemiological c…
View article: Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages
Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages Open
The members of the Mycobacterium tuberculosis complex (MTBC) causing human tuberculosis comprise ten phylogenetic lineages that differ in their geographical distribution. The human consequences of this phylogenetic diversity remain poorly …
View article: Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages
Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages Open
The members of the Mycobacterium tuberculosis complex (MTBC) causing human tuberculosis comprise ten phylogenetic lineages that differ in their geographical distribution. The human consequences of this phylogenetic diversity remain poorly …
View article: Drug-induced differential culturability in diverse strains of Mycobacterium tuberculosis
Drug-induced differential culturability in diverse strains of Mycobacterium tuberculosis Open
Under stress, bacteria display selective growth propensities on solid and liquid media. For Mycobacterium tuberculosis (Mtb), differentially culturable bacteria have been found in tuberculosis (TB) patient sputa. We hypothesized that antib…
View article: Clinical and bacterial determinants of unfavorable tuberculosis treatment outcomes: an observational study in Georgia
Clinical and bacterial determinants of unfavorable tuberculosis treatment outcomes: an observational study in Georgia Open
Tuberculosis (TB) remains a major public health concern. Improving TB control programmes and treatment success rates requires a deeper understanding of the factors that determine disease presentation and patient treatment outcomes. While t…
View article: Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania
Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania Open
Infectious diseases have affected humanity for millennia and are among the strongest selective forces. Tuberculosis (TB) is an ancient disease, caused by the human-adapted members of the Mycobacterium tuberculosis complex (MTBC). The outco…
View article: Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania
Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania Open
Infectious diseases have affected humanity for millennia and are among the strongest selective forces. Tuberculosis (TB) is an ancient disease, caused by the human-adapted members of the Mycobacterium tuberculosis complex (MTBC). The outco…
View article: Antibiotic lethality dictates mycobacterial infection outcomes
Antibiotic lethality dictates mycobacterial infection outcomes Open
Antibiotic development and treatment focus on bacterial growth inhibition, often with limited success. Here, we introduce Antimicrobial Single-Cell Testing (ASCT), an advanced imaging strategy to assess bacterial killing in real-time. By t…
View article: Granulysin antimicrobial activity promotes dormancy in Mycobacterium tuberculosis
Granulysin antimicrobial activity promotes dormancy in Mycobacterium tuberculosis Open
Human tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains a global public health threat. Granulomas constitute a hallmark of TB pathogenesis that can clear, contain or exacerbate an infection. Containment is exploited by M…
View article: A Genome-Focused Investigation Reveals the Emergence of a Mycobacterium tuberculosis Strain Related to Multidrug-Resistant Tuberculosis in the Amazon Region of Brazil
A Genome-Focused Investigation Reveals the Emergence of a Mycobacterium tuberculosis Strain Related to Multidrug-Resistant Tuberculosis in the Amazon Region of Brazil Open
A previous study in Pará, Northern Brazil, described a strain of Mycobacterium tuberculosis with a unique genotype (SIT2517/T1) associated with multidrug-resistant tuberculosis (MDR-TB). To improve our understanding of MDR-TB transmission …
View article: Onset of infectiousness explains differences in transmissibility across<i>Mycobacterium tuberculosis</i>lineages
Onset of infectiousness explains differences in transmissibility across<i>Mycobacterium tuberculosis</i>lineages Open
Mycobacterium tuberculosis complex (MTBC) lineages show substantial variability in virulence, but the epidemiological consequences of this variability have not been studied in detail. Here, we aimed for a lineage-specific epidemiological c…
View article: Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages
Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages Open
The members of the Mycobacterium tuberculosis complex (MTBC) causing human tuberculosis comprise 10 phylogenetic lineages that differ in their geographical distribution. The human consequences of this phylogenetic diversity remain poorly u…