Sonia Simonetti
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View article: Circulating receptor activator of nuclear factor kappa-B ligand (RANKL) levels predict response to immune checkpoint inhibitors in advanced non-small cell lung cancer (NSCLC)
Circulating receptor activator of nuclear factor kappa-B ligand (RANKL) levels predict response to immune checkpoint inhibitors in advanced non-small cell lung cancer (NSCLC) Open
Background Receptor activator of nuclear factor kappa-B ligand (RANKL) can directly promote tumor growth and indirectly support tumor immune evasion by altering the tumor microenvironment and immune cell responses. This study aimed to asse…
View article: Network approach in liquidomics landscape
Network approach in liquidomics landscape Open
Tissue-based biopsy is the present main tool to explore the molecular landscape of cancer, but it also has many limits to be frequently executed, being too invasive with the risk of side effects. These limits and the ability of cancer to c…
View article: Corrigendum: Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature
Corrigendum: Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature Open
[This corrects the article DOI: 10.3389/fimmu.2023.1043631.].
View article: Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature
Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature Open
Effective secondary response to antigen is a hallmark of immunological memory. However, the extent of memory CD8 T cell response to secondary boost varies at different times after a primary response. Considering the central role of memory …
View article: Durable CD8 T Cell Memory against SARS-CoV-2 by Prime/Boost and Multi-Dose Vaccination: Considerations on Inter-Dose Time Intervals
Durable CD8 T Cell Memory against SARS-CoV-2 by Prime/Boost and Multi-Dose Vaccination: Considerations on Inter-Dose Time Intervals Open
Facing the COVID-19 pandemic, anti-SARS-CoV-2 vaccines were developed at unprecedented pace, productively exploiting contemporary fundamental research and prior art. Large-scale use of anti-SARS-CoV-2 vaccines has greatly limited severe mo…
View article: Changes in bone turnover markers in patients without bone metastases receiving immune checkpoint inhibitors: An exploratory analysis
Changes in bone turnover markers in patients without bone metastases receiving immune checkpoint inhibitors: An exploratory analysis Open
Immune checkpoint inhibitors (ICIs) has revolutionized the treatment of different advanced solid tumors, but most patients develop severe immune-related adverse events (irAEs). Although a bi-directional crosstalk between bone and immune sy…
View article: Mouse dendritic cells in the steady state: Hypoxia, autophagy, and stem cell factor
Mouse dendritic cells in the steady state: Hypoxia, autophagy, and stem cell factor Open
Dendritic cells (DCs) are innate immune cells with a central role in immunity and tolerance. Under steady‐state, DCs are scattered in tissues as resting cells. Upon infection or injury, DCs get activated and acquire the full capacity to pr…
View article: Extensive plasma proteomic profiling revealed receptor activator of nuclear factor kappa-Β ligand (RANKL) as emerging biomarker of nivolumab clinical benefit in patients with metastatic renal cell carcinoma
Extensive plasma proteomic profiling revealed receptor activator of nuclear factor kappa-Β ligand (RANKL) as emerging biomarker of nivolumab clinical benefit in patients with metastatic renal cell carcinoma Open
Background The advent of immune checkpoint inhibitors (ICIs) have led to a paradigm change in the management of metastatic renal cell carcinoma (mRCC), nevertheless, the benefit of treatment is confined to a limited proportion of patients.…
View article: Osteoblast Secretome Modulated by Abiraterone Treatment Affects Castration Resistant Prostate Cancer Cell Proliferation
Osteoblast Secretome Modulated by Abiraterone Treatment Affects Castration Resistant Prostate Cancer Cell Proliferation Open
Abiraterone is a selective inhibitor of androgen biosynthesis approved for the treatment of metastatic patients affected by castration-resistant or castration-sensitive prostate cancer. Intriguingly, clinical data revealed that abiraterone…
View article: Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature
Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature Open
Summary Although the prime/boost interval can impact vaccine responses, the criteria for deciding its time length are poorly defined. To address this, we examined CD8 T cell responsiveness to boost in a BALB/c mouse model of intramuscular …
View article: Large-Scale Profiling of Extracellular Vesicles Identified miR-625-5p as a Novel Biomarker of Immunotherapy Response in Advanced Non-Small-Cell Lung Cancer Patients
Large-Scale Profiling of Extracellular Vesicles Identified miR-625-5p as a Novel Biomarker of Immunotherapy Response in Advanced Non-Small-Cell Lung Cancer Patients Open
Immune checkpoint inhibitors (ICIs) are largely used in the treatment of patients with advanced non-small-cell lung cancer (NSCLC). Novel biomarkers that provide biological information that could be useful for clinical management are neede…
View article: Biological Effects of Cyclin-Dependent Kinase Inhibitors Ribociclib, Palbociclib and Abemaciclib on Breast Cancer Bone Microenvironment
Biological Effects of Cyclin-Dependent Kinase Inhibitors Ribociclib, Palbociclib and Abemaciclib on Breast Cancer Bone Microenvironment Open
The CDK4/6 inhibitors (CDKi) palbociclib, ribociclib, and abemaciclib are currently approved in combination with anti-estrogen therapy for the treatment of advanced and/or metastatic hormone receptor-positive/HER2-neu-negative breast cance…
View article: Osteoblasts Promote Prostate Cancer Cell Proliferation Through Androgen Receptor Independent Mechanisms
Osteoblasts Promote Prostate Cancer Cell Proliferation Through Androgen Receptor Independent Mechanisms Open
Patients with metastatic prostate cancer frequently develop bone metastases that elicit significant skeletal morbidity and increased mortality. The high tropism of prostate cancer cells for bone and their tendency to induce the osteoblasti…
View article: <scp>OMIP</scp>‐079: Cell cycle of <scp>CD4</scp><sup>+</sup> and <scp>CD8</scp><sup>+</sup> naïve/memory T cell subsets, and of Treg cells from mouse spleen
<span>OMIP</span>‐079: Cell cycle of <span>CD4</span><sup>+</sup> and <span>CD8</span><sup>+</sup> naïve/memory T cell subsets, and of Treg cells from mouse spleen Open
A multicolor flow cytometry panel was designed and optimized to define the following nine mouse T cell subsets: Treg (CD3 + CD4 + CD8 − FoxP3 + ), CD4 + T naïve (CD3 + CD4 + CD8 − FoxP3 − CD44 int/low CD62L + ), CD4 + T central memory (CD3…
View article: Antitumor Effect of Cabozantinib in Bone Metastatic Models of Renal Cell Carcinoma
Antitumor Effect of Cabozantinib in Bone Metastatic Models of Renal Cell Carcinoma Open
Background: The presence of bone metastases in renal cell carcinoma (RCC) negatively affects patients’ survival. Data from clinical trials has highlighted a significant benefit of cabozantinib in bone metastatic RCC patients. Here, we eval…
View article: A DNA/Ki67-Based Flow Cytometry Assay for Cell Cycle Analysis of Antigen-Specific CD8 T Cells in Vaccinated Mice
A DNA/Ki67-Based Flow Cytometry Assay for Cell Cycle Analysis of Antigen-Specific CD8 T Cells in Vaccinated Mice Open
The cell cycle of antigen-specific T cells in vivo has been examined by using a few methods, all of which possess some limitations. Bromodeoxyuridine (BrdU) marks cells that are in or recently completed S-phase, and carboxyfluorescein succ…
View article: Breakthrough Cancer Pain Clinical Features and Differential Opioids Response: A Machine Learning Approach in Patients With Cancer From the IOPS-MS Study
Breakthrough Cancer Pain Clinical Features and Differential Opioids Response: A Machine Learning Approach in Patients With Cancer From the IOPS-MS Study Open
PURPOSE A large proportion of patients with cancer suffer from breakthrough cancer pain (BTcP). Several unmet clinical needs concerning BTcP treatment, such as optimal opioid dosages, are being investigated. In this analysis the hypothesis…
View article: Correction to: Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples
Correction to: Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples Open
An amendment to this paper has been published and can be accessed via the original article.
View article: Current and Emerging Biomarkers Predicting Bone Metastasis Development
Current and Emerging Biomarkers Predicting Bone Metastasis Development Open
Bone is one of the preferential sites of distant metastases from malignant tumors, with the highest prevalence observed in breast and prostate cancers. Patients with bone metastases (BMs) may experience skeletal-related events, such as sev…
View article: Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples
Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples Open
In a large number of cancer types, treatment selection depends on the presence of specific tumor biomarkers. Due to the dynamic nature of cancer, very often these predictive biomarkers are not uniformly present in all cancer cells. Tumor h…
View article: Dendritic cells modulate c‐kit expression on the edge between activation and death
Dendritic cells modulate c‐kit expression on the edge between activation and death Open
Dendritic cells (DCs) are key players in immunity and tolerance. Some DCs express c‐kit, the receptor for stem cell factor (SCF), nevertheless c‐kit functional role and the regulation of its expression in DCs are incompletely defined. We r…
View article: Antigen‐specific CD8 T cells in cell cycle circulate in the blood after vaccination
Antigen‐specific CD8 T cells in cell cycle circulate in the blood after vaccination Open
Although clonal expansion is a hallmark of adaptive immunity, the location(s) where antigen‐responding T cells enter cell cycle and complete it have been poorly explored. This lack of knowledge stems partially from the limited experimental…
View article: A previously missed population of antigen-specific CD8 T cells divides in the blood after vaccination
A previously missed population of antigen-specific CD8 T cells divides in the blood after vaccination Open
Although clonal expansion is a hallmark of adaptive immunity, the location(s) where antigen-responding T cells enter cell cycle and complete it have been poorly explored. This lack of knowledge stems partially from the limited experimental…