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View article: Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer
Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer Open
Associations between the gut microbiome and colorectal cancer (CRC) have been uncovered, but larger and more diverse studies are needed to assess their potential clinical use. We expanded upon 12 metagenomic datasets of patients with CRC (…
View article: Fasting-mimicking diet counteracts gut microbial dysbiosis in experimental Lynch syndrome
Fasting-mimicking diet counteracts gut microbial dysbiosis in experimental Lynch syndrome Open
The development of colorectal cancer (CRC) is largely influenced by hereditary factors, with up to one-third of cases linked to genetic predisposition. In parallel, environmental factors such as diet and intestinal microbiota play a signif…
View article: Multiple regulatory events contribute to a widespread circular RNA downregulation in precancer and early stage of colorectal cancer development
Multiple regulatory events contribute to a widespread circular RNA downregulation in precancer and early stage of colorectal cancer development Open
View article: <i>TACSTD2</i>expression marks the early transition to colon adenomas
<i>TACSTD2</i>expression marks the early transition to colon adenomas Open
This study aimed to address new molecular events occurring in precancerous stages of colorectal cancer (CRC) by integrated analysis of gene expression data and DNA methylation profiles. Whole-transcriptome sequencing analysis was performed…
View article: Exploring the gut DNA virome in fecal immunochemical test stool samples reveals associations with lifestyle in a large population-based study
Exploring the gut DNA virome in fecal immunochemical test stool samples reveals associations with lifestyle in a large population-based study Open
View article: Modulation of faecal miRNAs highlights the preventive effects of a Mediterranean low-inflammatory dietary intervention
Modulation of faecal miRNAs highlights the preventive effects of a Mediterranean low-inflammatory dietary intervention Open
View article: SnoRNA profiling in colorectal cancer and assessment of non-invasive biomarker capacity by ddPCR in fecal samples
SnoRNA profiling in colorectal cancer and assessment of non-invasive biomarker capacity by ddPCR in fecal samples Open
Small nucleolar RNAs (snoRNAs) have been identified dysregulated in several pathologies, and these alterations can be detected in tissues and in circulation. The main aim of this study was to analyze the whole snoRNome in advanced colorect…
View article: Small noncoding RNAs and sperm nuclear basic proteins reflect the environmental impact on germ cells
Small noncoding RNAs and sperm nuclear basic proteins reflect the environmental impact on germ cells Open
Background Molecular techniques can complement conventional spermiogram analyses to provide new information on the fertilizing potential of spermatozoa and to identify early alterations due to environmental pollution. Methods Here, we pres…
View article: Additional file 4: Table S3
Additional file 4: Table S3 Open
Results from the Spearman correlation analysis between DE miRNA levels and analyzed parameters.
View article: Additional file 3: Table S2
Additional file 3: Table S2 Open
A. Sample data and small RNA-Seq alignment statistics. B. Results from the differential expression analysis. C. List of validated DE miRNA-gene target interactions. D. Number of studies supporting each mi…
View article: Additional file 5: Table S4
Additional file 5: Table S4 Open
A. Levels of DE miRNAs of this study in semen samples from Pauli et al. and Morgan et al. B. Levels of DE miRNAs of this study in semen samples characterized by high or low fertilization rate. C. Levels of mice homolog…
View article: Additional file 2: Table S1
Additional file 2: Table S1 Open
Concentration of trace metals in the analyzed samples.
View article: Additional file 2: Table S1
Additional file 2: Table S1 Open
Concentration of trace metals in the analyzed samples.
View article: Additional file 6: Table S5
Additional file 6: Table S5 Open
A. Results from the differential expression analysis of sncRNA levels between LF and VSL samples. B. Results from the correlation analysis between the levels of DE piRNAs in our analysis and the semen parameters measured for …
View article: Effect of traditional or heat‐not‐burn cigarette smoking on circulating <scp>miRNAs</scp> in healthy subjects
Effect of traditional or heat‐not‐burn cigarette smoking on circulating <span>miRNAs</span> in healthy subjects Open
Background Traditional combustion cigarette (TCC) smoking is an established risk factor for several types of cancer and cardiovascular diseases. Circulating microRNAs (miRNAs) represent key molecules mediating pathogenetic mechanisms, and …
View article: Profiling small RNAs in fecal immunochemical tests: is it possible?
Profiling small RNAs in fecal immunochemical tests: is it possible? Open
View article: Variability of the Human Serum Metabolome over 3 Months in the EXPOsOMICS Personal Exposure Monitoring Study
Variability of the Human Serum Metabolome over 3 Months in the EXPOsOMICS Personal Exposure Monitoring Study Open
Liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) and untargeted metabolomics are increasingly used in exposome studies to study the interactions between nongenetic factors and the blood metabolome. To reliably a…
View article: Processed metabolomic data from the EXPOsOMICS Personal Exposure Monitoring study
Processed metabolomic data from the EXPOsOMICS Personal Exposure Monitoring study Open
Metabolomic data from the 'Variability of the Human Serum Metabolome over 3 Months in the EXPOsOMICS Personal Exposure Monitoring Study' paper DOI: 10.1021/acs.est.3c03233 . The data was originally collected and generated by the multicente…
View article: Processed metabolomic data from the EXPOsOMICS Personal Exposure Monitoring study
Processed metabolomic data from the EXPOsOMICS Personal Exposure Monitoring study Open
Metabolomic data from the 'Variability of the Human Serum Metabolome over 3 Months in the EXPOsOMICS Personal Exposure Monitoring Study' paper DOI: 10.1021/acs.est.3c03233 . The data was originally collected and generated by the multicente…
View article: Exclusive heat-not-burn cigarette smoking alters the profile of circulating microRNAs
Exclusive heat-not-burn cigarette smoking alters the profile of circulating microRNAs Open
Background Traditional combustion cigarette (TCC) smoking is an established risk factor for several types of cancer and cardiovascular diseases. Circulating microRNAs (miRNAs) represent key molecules mediating pathogenetic mechanisms, and …
View article: A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study
A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study Open
View article: Profiling small RNAs in CRC screening samples such as the widely used fecal immunochemical test, is it possible?
Profiling small RNAs in CRC screening samples such as the widely used fecal immunochemical test, is it possible? Open
Faecal microRNAs represent promising molecules with potential clinical interest as non-invasive diagnostic and prognostic biomarkers for their stability and detectability. Colorectal cancer (CRC) screening based on the fecal immunochemical…
View article: Gluten-free diet affects fecal small non-coding RNA profiles and microbiome composition in celiac disease supporting a host-gut microbiota crosstalk
Gluten-free diet affects fecal small non-coding RNA profiles and microbiome composition in celiac disease supporting a host-gut microbiota crosstalk Open
Current treatment for celiac disease (CD) is adhering to a gluten-free diet (GFD), although its long-term molecular effects are still undescribed. New molecular features detectable in stool may improve and facilitate noninvasive clinical m…
View article: Supplementary_Table_3_Correlation.xlsx
Supplementary_Table_3_Correlation.xlsx Open
Results from the Spearman correlation analysis between DE miRNA levels and analyzed parameters.
View article: Supplementary_Table_4_miRNA_levels_public_datasets.xlsx
Supplementary_Table_4_miRNA_levels_public_datasets.xlsx Open
A. Levels of DE miRNAs of this study in semen samples from Pauli et al. and Morgan et al. B. Levels of DE miRNAs of this study in semen samples characterized by high or low fertilization rate. C. Levels of mice homolog…
View article: Supplementary_Table_5_Other_sncRNAs.xlsx
Supplementary_Table_5_Other_sncRNAs.xlsx Open
A. Results from the differential expression analysis of sncRNA levels between LF and VSL samples. B. Results from the correlation analysis between the levels of DE piRNAs in our analysis and the semen parameters measured for …
View article: Supplementary_Table_1_Trace_metals.xlsx
Supplementary_Table_1_Trace_metals.xlsx Open
Concentration of trace metals in the analyzed samples.
View article: Supplementary_Table_2_miRNA_analysis.xlsx
Supplementary_Table_2_miRNA_analysis.xlsx Open
A. Sample data and small RNA-Seq alignment statistics. B. Results from the differential expression analysis. C. List of validated DE miRNA-gene target interactions. D. Number of studies supporting each mi…
View article: The 8q24 region hosts miRNAs altered in biospecimens of colorectal and bladder cancer patients
The 8q24 region hosts miRNAs altered in biospecimens of colorectal and bladder cancer patients Open
Background The 8q24 locus is enriched in cancer‐associated polymorphisms and, despite containing relatively few protein‐coding genes, it hosts the MYC oncogene and other genetic elements connected to tumorigenesis, including microRNAs (miR…
View article: Gluten-Free Diet Adherence Affects Faecal Small Non-Coding RNA Profiles and Microbiome Composition in Celiac Disease Subjects: Novel Biomarkers from Host-Gut Microbiota Cross-Talk
Gluten-Free Diet Adherence Affects Faecal Small Non-Coding RNA Profiles and Microbiome Composition in Celiac Disease Subjects: Novel Biomarkers from Host-Gut Microbiota Cross-Talk Open