Sonja Eberth
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View article: Molecular Characterization and Subtyping of Breast Cancer Cell Lines Provide Novel Insights into Cancer Relevant Genes
Molecular Characterization and Subtyping of Breast Cancer Cell Lines Provide Novel Insights into Cancer Relevant Genes Open
Continuous cell lines are important and commonly used in vitro models in breast cancer (BC) research. Selection of the appropriate model cell line is crucial and requires consideration of their molecular characteristics. To characterize BC…
View article: Supplementary Figure 1 from The NADPH Oxidase Inhibitor Imipramine-Blue in the Treatment of Burkitt Lymphoma
Supplementary Figure 1 from The NADPH Oxidase Inhibitor Imipramine-Blue in the Treatment of Burkitt Lymphoma Open
PDF - 1109K, Blood and lymphatic vessel density in experimental BL2B95 tumors treated with IB in the CAM model.
View article: Data from The NADPH Oxidase Inhibitor Imipramine-Blue in the Treatment of Burkitt Lymphoma
Data from The NADPH Oxidase Inhibitor Imipramine-Blue in the Treatment of Burkitt Lymphoma Open
Burkitt lymphoma is a rare malignancy arising from B cells. Current chemotherapeutic regimens achieve excellent overall survival rates in children, but less impressive rates in adults. There are cases with poor outcome caused by toxic effe…
View article: Supplementary Figure 1 from The NADPH Oxidase Inhibitor Imipramine-Blue in the Treatment of Burkitt Lymphoma
Supplementary Figure 1 from The NADPH Oxidase Inhibitor Imipramine-Blue in the Treatment of Burkitt Lymphoma Open
PDF - 1109K, Blood and lymphatic vessel density in experimental BL2B95 tumors treated with IB in the CAM model.
View article: Data from The NADPH Oxidase Inhibitor Imipramine-Blue in the Treatment of Burkitt Lymphoma
Data from The NADPH Oxidase Inhibitor Imipramine-Blue in the Treatment of Burkitt Lymphoma Open
Burkitt lymphoma is a rare malignancy arising from B cells. Current chemotherapeutic regimens achieve excellent overall survival rates in children, but less impressive rates in adults. There are cases with poor outcome caused by toxic effe…
View article: DSMZCellDive: Diving into high-throughput cell line data
DSMZCellDive: Diving into high-throughput cell line data Open
Human and animal cell lines serve as model systems in a wide range of life sciences such as cancer and infection research or drug screening. Reproducible data are highly dependent on authenticated, contaminant-free cell lines, no better de…
View article: Downregulation of STAT3 in Epstein-Barr Virus-Positive Hodgkin Lymphoma
Downregulation of STAT3 in Epstein-Barr Virus-Positive Hodgkin Lymphoma Open
STAT3 is a transcription factor which is activated via various signaling transduction pathways or Epstein-Barr virus (EBV) infection and plays an oncogenic role in lymphoid malignancies including Hodgkin lymphoma (HL). The tumor cells of H…
View article: The genomic and transcriptional landscape of primary central nervous system lymphoma
The genomic and transcriptional landscape of primary central nervous system lymphoma Open
Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of PCNSL have not been fully elucidated. Here, we profile and compar…
View article: DSMZCellDive: Diving into high-throughput cell line data
DSMZCellDive: Diving into high-throughput cell line data Open
Human and animal cell lines serve as model systems in a wide range of life sciences such as cancer and infection research or drug screening. Reproducible data are highly dependent on authenticated, contaminant-free cell lines, no better de…
View article: Cross contamination meets misclassification: Awakening of <scp>CHP</scp>‐100 from sleeping beauty sleep—A reviewed model for Ewing's sarcoma
Cross contamination meets misclassification: Awakening of <span>CHP</span>‐100 from sleeping beauty sleep—A reviewed model for Ewing's sarcoma Open
A human cell line of neuroblastic tissue, which was believed to have been lost to science due to its unavailability in public repositories, is revived and reclassified. In the 1970s, a triple set of neuroblastoma (NB) cell lines became ava…
View article: There is a Scientific Need for the Right Leukemia-Lymphoma Cell Lines
There is a Scientific Need for the Right Leukemia-Lymphoma Cell Lines Open
STATEMENT OF SIGNIFICANCE Leukemia-Lymphoma cell lines are important and widely used research tools. Choosing the right cell line is contingent upon its applicability as in vitro model and can be assured by authentication of the cell line,…
View article: Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells
Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells Open
Deficiency in several of the classical human RAD51 paralogs [RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3] is associated with cancer predisposition and Fanconi anemia. To investigate their functions, isogenic disruption mutants for each were ge…
View article: Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells
Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells Open
Deficiency in several of the classical human RAD51 paralogs [RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3] is associated with cancer predisposition and Fanconi anemia. To investigate their functions, isogenic disruption mutants for each were ge…
View article: ATP Content and Cell Viability as Indicators for Cryostress Across the Diversity of Life
ATP Content and Cell Viability as Indicators for Cryostress Across the Diversity of Life Open
In many natural environments, organisms get exposed to low temperature and/or to strong temperature shifts. Also, standard preservation protocols for live cells or tissues involve ultradeep freezing in or above liquid nitrogen (-196°C or -…
View article: Suitability of Yin Yang 1 transcript and protein levels for biomarker studies in B cell non-Hodgkin lymphoma
Suitability of Yin Yang 1 transcript and protein levels for biomarker studies in B cell non-Hodgkin lymphoma Open
Our results point out the necessity to focus on YY1 protein expression to understand the potential role of YY1 as an oncogene and to unravel its suitability as clinical biomarker in B-NHL.
View article: MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation
MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation Open
The circadian clock and the cell cycle are major cellular systems that organize global physiology in temporal fashion. It seems conceivable that the potentially conflicting programs are coordinated. We show here that overexpression of MYC …
View article: The Wnt Pathway Target Gene &lt;i&gt;CCND1&lt;/i&gt; Changes Mitochondrial Localization and Decreases Mitochondrial Activity in Colorectal Cancer Cell Line SW480
The Wnt Pathway Target Gene <i>CCND1</i> Changes Mitochondrial Localization and Decreases Mitochondrial Activity in Colorectal Cancer Cell Line SW480 Open
Mutations leading to constitutive activation of the Wnt pathway and its target genes are frequently observed in cancer. The Wnt pathway promotes cell proliferation and increasing evidence supports its role also in cancer cell metabolism. T…
View article: Genomic Landscape of Primary Mediastinal B-Cell Lymphoma Cell Lines
Genomic Landscape of Primary Mediastinal B-Cell Lymphoma Cell Lines Open
Primary mediastinal B-Cell lymphoma (PMBL) is a recently defined entity comprising ~2-10% non-Hodgkin lymphomas (NHL). Unlike most NHL subtypes, PMBL lacks recurrent gene rearrangements to serve as biomarkers or betray target genes. While …
View article: MINCR is a MYC-induced lncRNA able to modulate MYC’s transcriptional network in Burkitt lymphoma cells
MINCR is a MYC-induced lncRNA able to modulate MYC’s transcriptional network in Burkitt lymphoma cells Open
Significance Gains of the MYC gene are the most common imbalances in cancer and are associated with poor prognosis, particularly in B-cell lymphoma. Recent advances in DNA sequencing have revealed the existence of thousands of long noncodi…