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View article: Author response: Natural xanthones as α-Mangostin induce vasorelaxation via binding to key gating residues in the S6 domain of BK channels
Author response: Natural xanthones as α-Mangostin induce vasorelaxation via binding to key gating residues in the S6 domain of BK channels Open
View article: Natural xanthones as α-Mangostin induce vasorelaxation via binding to key gating residues in the S6 domain of BK channels
Natural xanthones as α-Mangostin induce vasorelaxation via binding to key gating residues in the S6 domain of BK channels Open
Polyphenolic compounds are widely explored for health benefits, including hypertension, but their active ingredients, molecular targets, and mechanisms remain poorly defined. We identify the xanthone Mangostin from Garcinia mangostana as a…
View article: Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics
Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics Open
View article: Thermosensitivity of TREK K2P channels is controlled by a PKA switch and depends on the microtubular network
Thermosensitivity of TREK K2P channels is controlled by a PKA switch and depends on the microtubular network Open
Temperature sensing is an essential component of animal perception and enables individuals to avoid painful or lethal temperatures. Many temperature sensors in central and peripheral neurons are ion channels. Here, we focus on the thermose…
View article: A comprehensive in-vitro/in-vivo screening toolbox for the elucidation of glucose homeostasis modulating properties of plant extracts (from roots) and its bioactives
A comprehensive in-vitro/in-vivo screening toolbox for the elucidation of glucose homeostasis modulating properties of plant extracts (from roots) and its bioactives Open
Plant extracts are increasingly recognized for their potential in modulating (postprandial) blood glucose levels. In this context, root extracts are of particular interest due to their high concentrations and often unique spectrum of plant…
View article: Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2
Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2 Open
Two-pore domain K + (K 2P ) channel activity was previously thought to be controlled primarily via a selectivity filter (SF) gate. However, recent crystal structures of TASK-1 and TASK-2 revealed a lower gate at the cytoplasmic pore entran…
View article: The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism
The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism Open
Work over the past three decades has greatly advanced our understanding of the regulation of Kir K+ channels by polyanionic lipids of the phosphoinositide (e.g., PIP2) and fatty acid metabolism (e.g., oleoyl-CoA). However, comparatively li…
View article: The versatile regulation of K<sub>2P</sub> channels by polyanionic lipids of the phosphoinositide (PIP<sub>2</sub>) and fatty acid metabolism (LC-CoA)
The versatile regulation of K<sub>2P</sub> channels by polyanionic lipids of the phosphoinositide (PIP<sub>2</sub>) and fatty acid metabolism (LC-CoA) Open
Work of the past three decades provided tremendous insight into the regulation of K + channels - in particular K ir channels - by polyanionic lipids of the phosphoinositide (e.g. PIP 2 ) and fatty acid metabolism (e.g. oleoyl-CoA). However…
View article: Characterisation of the Versatile Gating Behaviour in Talk-2 K2P Channels
Characterisation of the Versatile Gating Behaviour in Talk-2 K2P Channels Open
View article: A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels
A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels Open
View article: A Non-Canonical Voltage Sensor Controls Gating in K2P K+ Channels
A Non-Canonical Voltage Sensor Controls Gating in K2P K+ Channels Open