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Author Response: Tailoring Tfh profiles enhances antibody persistence to a clade C HIV-1 vaccine in rhesus macaques Open

Anil Verma, Chase E Hawes, Sonny R. Elizaldi, Justin C. Smith, Dhivyaa Rajasundaram , et al. · 2024

Tailoring Tfh Profiles Enhances Antibody Persistence to a Clade C HIV-1 Vaccine in Rhesus Macaques Open

Anil Verma, Chase E Hawes, Sonny R. Elizaldi, Justin C. Smith, Dhivyaa Rajasundaram , et al. · 2024

CD4 T follicular helper cells (Tfh) are essential for establishing serological memory and have distinct helper attributes that impact both the quantity and quality of the antibody response. Insights into Tfh subsets that promote antibody p…

Author Response: Tailoring Tfh Profiles Enhances Antibody Persistence to a Clade C HIV-1 Vaccine in Rhesus Macaques Open

Anil Verma, Chase E Hawes, Sonny R. Elizaldi, Justin C. Smith, Dhivyaa Rajasundaram , et al. · 2024

CD4 T follicular helper cells (Tfh) are essential for establishing serological memory and have distinct helper attributes that impact both the quantity and quality of the antibody response. Insights into Tfh subsets that promote antibody p…

Reviewer #1 (Public Review): Tailoring Tfh Profiles Enhances Antibody Persistence to a Clade C HIV-1 Vaccine in Rhesus Macaques Open

Anil Verma, Chase E Hawes, Sonny R. Elizaldi, Justin C. Smith, Dhivyaa Rajasundaram , et al. · 2023

CD4 T follicular helper cells (Tfh) are essential for establishing serological memory and have distinct helper attributes that impact both the quantity and quality of the antibody response. Insights into Tfh subsets that promote antibody p…

Reviewer #2 (Public Review): Tailoring Tfh Profiles Enhances Antibody Persistence to a Clade C HIV-1 Vaccine in Rhesus Macaques Open

Anil Verma, Chase E Hawes, Sonny R. Elizaldi, Justin C. Smith, Dhivyaa Rajasundaram , et al. · 2023

CD4 T follicular helper cells (Tfh) are essential for establishing serological memory and have distinct helper attributes that impact both the quantity and quality of the antibody response. Insights into Tfh subsets that promote antibody p…

Author Response: Tailoring Tfh Profiles Enhances Antibody Persistence to a Clade C HIV-1 Vaccine in Rhesus Macaques Open

Anil Verma, Chase E Hawes, Sonny R. Elizaldi, Justin C. Smith, Dhivyaa Rajasundaram , et al. · 2023

CD4 T follicular helper cells (Tfh) are essential for establishing serological memory and have distinct helper attributes that impact both the quantity and quality of the antibody response. Insights into Tfh subsets that promote antibody p…

Tailoring Tfh Profiles Enhances Antibody Persistence to a Clade C HIV-1 Vaccine in Rhesus Macaques Open

Anil Verma, Chase E Hawes, Sonny R. Elizaldi, Justin C. Smith, Dhivyaa Rajasundaram , et al. · 2023

CD4 T follicular helper cells (Tfh) are essential for establishing serological memory and have distinct helper attributes that impact both the quantity and quality of the antibody response. Insights into Tfh subsets that promote antibody p…

CCR7+ CD4 T Cell Immunosurveillance Disrupted in Chronic SIV-Induced Neuroinflammation in Rhesus Brain Open

Sonny R. Elizaldi, Chase E Hawes, Anil Verma, Ashok Reddy Dinasarapu, Yashavanth Shaan Lakshmanappa , et al. · 2023

CD4 T cells survey and maintain immune homeostasis in the brain, yet their differentiation states and functional capabilities remain unclear. Our approach, combining single-cell transcriptomic analysis, ATAC-seq, spatial transcriptomics, a…

CD4 T cell Responses in the CNS during SIV infection Open

Sonny R. Elizaldi, Anil Verma, Zhong-Min Ma, Sean Ott, Dhivyaa Rajasundaram , et al. · 2023

Virologic suppression with antiretroviral therapy (ART) has significantly improved health outcomes for people living with HIV, yet challenges related to chronic inflammation in the central nervous system (CNS) - known as Neuro-HIV-persist.…

Tailoring T <sub>fh</sub> Profiles Enhances Antibody Persistence to a Clade C HIV-1 Vaccine in Rhesus Macaques Open

Anil Verma, Chase E Hawes, Sonny R. Elizaldi, Justin C. Smith, Dhivyaa Rajasundaram , et al. · 2023

CD4 T follicular helper cells (T fh ) are essential for establishing serological memory and have distinct helper attributes that impact both the quantity and quality of the antibody response. Insights into T fh subsets that promote antibod…

Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge one year later Open

Emma C. Milligan, Katherine J. Olstad, Caitlin A. Williams, Michael L. Mallory, Patricio Cano , et al. · 2023

The U.S. Food and Drug Administration only gave emergency use authorization of the BNT162b2 and mRNA-1273 SARS-CoV-2 vaccines for infants 6 months and older in June 2022. Yet questions regarding the durability of vaccine efficacy, especial…

Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge 1 year later Open

Emma C. Milligan, Katherine J. Olstad, Caitlin A. Williams, Michael L. Mallory, Patricio Cano , et al. · 2022

The U.S. Food and Drug Administration only gave emergency use authorization of the BNT162b2 and mRNA-1273 SARS-CoV-2 vaccines for infants 6 months and older in June 2022. Yet questions regarding the durability of vaccine efficacy, especial…

Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection Open

Chase E. Hawes, Sonny R. Elizaldi, Danielle Beckman, Giovanne B. Diniz, Yashavanth Shaan Lakshmanappa , et al. · 2022

Background : Immunosurveillance of the central nervous system (CNS) is vital to resolve infection and injury. However, immune activation within the CNS in the setting of chronic viral infections, such as HIV-1, is strongly linked to progre…

Additional file 2 of Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection Open

Chase E. Hawes, Sonny R. Elizaldi, Danielle Beckman, Giovanne B. Diniz, Yashavanth Shaan Lakshmanappa , et al. · 2022

Additional file 2: Table S2. Normalized Read Counts. Normalized read counts in units of Log2 Counts per Million (CPM). Sample IDs are listed in row 1 and correspond to Code in Table S1. Corresponding Gene.stable.ID and Gene names are liste…

SARS-CoV-2 Infects Neurons and Induces Neuroinflammation in a Non-Human Primate Model of COVID-19 Open

Danielle Beckman, Alyssa Bonillas, Giovanne B. Diniz, Sean Ott, Jamin W. Roh , et al. · 2022

Gut germinal center regeneration and enhanced antiviral immunity by mesenchymal stem/stromal cells in SIV infection Open

Mariana G. Weber, Chara J. Walters-Laird, Amir Kol, Clarissa Santos Rocha, Lauren A. Hirao , et al. · 2021

Although antiretroviral therapy suppresses HIV replication, it does not eliminate viral reservoirs or restore damaged lymphoid tissue, posing obstacles to HIV eradication. Using the SIV model of AIDS, we investigated the effect of mesenchy…

SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques Open

Yashavanth Shaan Lakshmanappa, Sonny R. Elizaldi, Jamin W. Roh, Brian Schmidt, Timothy D. Carroll , et al. · 2021

CD4 T follicular helper (T fh ) cells are important for the generation of durable and specific humoral protection against viral infections. The degree to which SARS-CoV-2 infection generates T fh cells and stimulates the germinal center (G…

Sclerostin depletion induces inflammation in the bone marrow of mice Open

Cristine Donham, Betsabel Chicana, Alexander G. Robling, Asmaa Mohamed, Sonny R. Elizaldi , et al. · 2020

Romosozumab, a humanized monoclonal antibody specific for sclerostin, has been approved for treatment of post-menopausal women with osteoporosis at high risk for fracture. In several Phase III clinical trials, romosozumab decreased the ris…

SARS-CoV-2 infection induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques Open

Sonny R. Elizaldi, Yashavanth Shaan Lakshmanappa, Jamin W. Roh, Brian Schmidt, Timothy D. Carroll , et al. · 2020

CD4 T follicular helper (T fh ) cells are important for the generation of durable and specific humoral protection against viral infections. The degree to which SARS-CoV-2 infection generates T fh cells and stimulates the germinal center re…

SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques Open

Sonny R. Elizaldi, Yashavanth Shaan Lakshmanappa, Jamin W. Roh, Brian Schmidt, Timothy D. Carroll , et al. · 2020

CD4 T follicular helper (T fh ) cells are important for the generation of long-lasting and specific humoral protection against viral infections. The degree to which SARS-CoV-2 infection generates T fh cells and stimulates the germinal cent…

Antibody and flow cytometry data following inoculation of rhesus macaques with SARS-CoV-2 Open

Yashavanth Shaan Lakshmanappa, Sonny R. Elizaldi, Jamin W. Roh, Brian Schmidt, Timothy D. Carroll , et al. · 2020

This data record consists of a single dataset, Iyer Source data.xlsx, in .xlsx file format. The file includes all the antibody and flow cytometry data supporting the figures and supplementary figures in the related article. T…

Sostdc1 Regulates NK Cell Maturation and Cytotoxicity Open

Alberto J. Millan, Sonny R. Elizaldi, Eric M. Lee, Jeffrey O. Aceves, Deepa K. Murugesh , et al. · 2019

NK cells are innate-like lymphocytes that eliminate virally infected and cancerous cells, but the mechanisms that control NK cell development and cytotoxicity are incompletely understood. We identified roles for sclerostin domain–containin…

Sostdc1 regulates natural killer cell maturation and cytotoxicity Open

Alberto J. Millan, Sonny R. Elizaldi, Eric M. Lee, Jeffrey O. Aceves, Deepa K. Murugesh , et al. · 2018

Natural killer (NK) cells are specialized lymphocytes with the innate ability to eliminate virally infected and cancerous cells, but the mechanisms that control NK cell development and cytotoxicity are incompletely understood. We identifie…

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