Sonoko Narisawa
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View article: TNAP dephosphorylates phosphocholine and phosphoethanolamine and participates in triglyceride transport from the liver to the bloodstream
TNAP dephosphorylates phosphocholine and phosphoethanolamine and participates in triglyceride transport from the liver to the bloodstream Open
Tissue-nonspecific alkaline phosphatase (TNAP) is primarily known for its role in skeletal mineralization, through the hydrolysis of inorganic pyrophosphate (PPi). Here we demonstrate that TNAP-knockout mice exhibit liver steato…
View article: ENPP1 inhibition as a therapeutic approach for later-onset hypophosphatasia
ENPP1 inhibition as a therapeutic approach for later-onset hypophosphatasia Open
Hypophosphatasia (HPP) is caused by loss-of-function mutations in the human ALPL gene that encodes tissue-nonspecific alkaline phosphatase (TNAP), whose deficiency results in the accumulation of the calcification inhibitor inorganic pyroph…
View article: Glycoproteomic profile of human tissue-nonspecific alkaline phosphatase expressed in osteoblasts
Glycoproteomic profile of human tissue-nonspecific alkaline phosphatase expressed in osteoblasts Open
Tissue-nonspecific alkaline phosphatase (TNALP) is a glycoprotein expressed by osteoblasts that promotes bone mineralization. TNALP catalyzes the hydrolysis of the mineralization inhibitor inorganic pyrophosphate and ATP to provide inorgan…
View article: The biochemistry of mineralizing extracellular vesicles. Part I: The role of phosphatases
The biochemistry of mineralizing extracellular vesicles. Part I: The role of phosphatases Open
View article: Dentoalveolar Alterations in an <scp>Adenine‐Induced</scp> Chronic Kidney Disease Mouse Model
Dentoalveolar Alterations in an <span>Adenine‐Induced</span> Chronic Kidney Disease Mouse Model Open
Chronic kidney disease (CKD) is characterized by kidney damage and loss of renal function. CKD mineral and bone disorder (CKD–MBD) describes the dysregulation of mineral homeostasis, including hyperphosphatemia and elevated parathyroid hor…
View article: Gene Therapy Using Recombinant <scp>AAV</scp> Type 8 Vector Encoding <scp>TNAP‐D<sub>10</sub></scp> Improves the Skeletal Phenotypes in Murine Models of Osteomalacia
Gene Therapy Using Recombinant <span>AAV</span> Type 8 Vector Encoding <span>TNAP‐D<sub>10</sub></span> Improves the Skeletal Phenotypes in Murine Models of Osteomalacia Open
Hypophosphatasia (HPP), caused by loss‐of‐function mutations in the ALPL gene encoding tissue‐nonspecific alkaline phosphatase (TNAP), is characterized by skeletal and dental hypomineralization that can vary in severity from life‐threateni…
View article: Perspective on Dentoalveolar Manifestations Resulting From PHOSPHO1 Loss-of-Function: A Form of Pseudohypophosphatasia?
Perspective on Dentoalveolar Manifestations Resulting From PHOSPHO1 Loss-of-Function: A Form of Pseudohypophosphatasia? Open
Mineralization of the skeleton occurs by several physicochemical and biochemical processes and mechanisms that facilitate the deposition of hydroxyapatite (HA) in specific areas of the extracellular matrix (ECM). Two key phosphatases, phos…
View article: TNAP upregulation is a critical factor in Tauopathies and its blockade ameliorates neurotoxicity and increases life-expectancy
TNAP upregulation is a critical factor in Tauopathies and its blockade ameliorates neurotoxicity and increases life-expectancy Open
View article: Prenatal enzyme replacement therapy for Akp2−/− mice with lethal hypophosphatasia
Prenatal enzyme replacement therapy for Akp2−/− mice with lethal hypophosphatasia Open
View article: Author response for "Gene Therapy Using Adeno-Associated Virus Serotype 8 Encoding TNAP-D-10 Improves the Skeletal and Dentoalveolar Phenotypes in Alpl(-/-) Mice"
Author response for "Gene Therapy Using Adeno-Associated Virus Serotype 8 Encoding TNAP-D-10 Improves the Skeletal and Dentoalveolar Phenotypes in Alpl(-/-) Mice" Open
View article: Author response for "Gene Therapy Using Adeno-Associated Virus Serotype 8 Encoding TNAP-D-10 Improves the Skeletal and Dentoalveolar Phenotypes in Alpl(-/-) Mice"
Author response for "Gene Therapy Using Adeno-Associated Virus Serotype 8 Encoding TNAP-D-10 Improves the Skeletal and Dentoalveolar Phenotypes in Alpl(-/-) Mice" Open
View article: Gene Therapy Using Adeno-Associated Virus Serotype 8 Encoding TNAP-D10 Improves the Skeletal and Dentoalveolar Phenotypes in Alpl−/− Mice
Gene Therapy Using Adeno-Associated Virus Serotype 8 Encoding TNAP-D10 Improves the Skeletal and Dentoalveolar Phenotypes in Alpl−/− Mice Open
Hypophosphatasia (HPP) is caused by loss-of-function mutations in the ALPL gene that encodes tissue-nonspecific alkaline phosphatase (TNAP), whose deficiency results in the accumulation of extracellular inorganic pyrophosphate (PPi), a pot…
View article: Visualization of asfotase alfa-binding to sites of calcification in vivo
Visualization of asfotase alfa-binding to sites of calcification in vivo Open
View article: Tissue-nonspecific Alkaline Phosphatase Blockade Ameliorates Behavioural Deficits and Life-expectancy on Tauopathies
Tissue-nonspecific Alkaline Phosphatase Blockade Ameliorates Behavioural Deficits and Life-expectancy on Tauopathies Open
The authors have withdrawn this preprint due to erroneous posting.
View article: Tissue-nonspecific Alkaline Phosphatase Blockade Ameliorates Behavioural Deficits and Life-expectancy on Tauopathies
Tissue-nonspecific Alkaline Phosphatase Blockade Ameliorates Behavioural Deficits and Life-expectancy on Tauopathies Open
The authors have removed this preprint from Research Square.
View article: Visualization of Mineral-Targeted Alkaline Phosphatase Binding to Sites of Calcification In Vivo
Visualization of Mineral-Targeted Alkaline Phosphatase Binding to Sites of Calcification In Vivo Open
A mineral-targeted form of recombinant tissue-nonspecific alkaline phosphatase (TNAP), asfotase alfa, was approved multinationally as an enzyme replacement therapy for hypophosphatasia in 2015. Two reports to date have shown evidence of bi…
View article: Author response for "Visualization of mineral‐targeted alkaline phosphatase binding to sites of calcification <i>in vivo</i>"
Author response for "Visualization of mineral‐targeted alkaline phosphatase binding to sites of calcification <i>in vivo</i>" Open
View article: Inhibition of tissue‐nonspecific alkaline phosphatase protects against medial arterial calcification and improves survival probability in the CKD‐MBD mouse model
Inhibition of tissue‐nonspecific alkaline phosphatase protects against medial arterial calcification and improves survival probability in the CKD‐MBD mouse model Open
Medial arterial calcification (MAC) is a major complication of chronic kidney disease (CKD) and an indicator of poor prognosis. Aortic overexpression of tissue‐nonspecific alkaline phosphatase (TNAP) accelerates MAC formation. The present …
View article: Abstracts from the First Scientific Meeting of the Soft Bones Foundation
Abstracts from the First Scientific Meeting of the Soft Bones Foundation Open
group of 50 clinicians, clinical investigators, and basic scientists gathered with other interested individuals to convene the First Scientific Meeting of the Soft Bones Foundation.They reviewed current understanding and uncertainties conc…
View article: Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis
Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis Open
View article: A Role of Intestinal Alkaline Phosphatase 3 (Akp3) in Inorganic Phosphate Homeostasis
A Role of Intestinal Alkaline Phosphatase 3 (Akp3) in Inorganic Phosphate Homeostasis Open
Background/Aims: Hyperphosphatemia is a serious complication of late-stage chronic kidney disease (CKD). Intestinal inorganic phosphate (Pi) handling plays an important role in Pi homeostasis in CKD. We investigated whether i…
View article: Osteopontin regulates dentin and alveolar bone development and mineralization
Osteopontin regulates dentin and alveolar bone development and mineralization Open
View article: Bone Alkaline Phosphatase and Tartrate-Resistant Acid Phosphatase: Potential Co-regulators of Bone Mineralization
Bone Alkaline Phosphatase and Tartrate-Resistant Acid Phosphatase: Potential Co-regulators of Bone Mineralization Open
View article: Conditional <i>Alpl</i> Ablation Phenocopies Dental Defects of Hypophosphatasia
Conditional <i>Alpl</i> Ablation Phenocopies Dental Defects of Hypophosphatasia Open
Loss-of-function mutations in ALPL result in hypophosphatasia (HPP), an inborn error of metabolism that causes defective skeletal and dental mineralization. ALPL encodes tissue-nonspecific alkaline phosphatase, an enzyme expressed in bone,…
View article: Role of PHOSPHO1 in Periodontal Development and Function
Role of PHOSPHO1 in Periodontal Development and Function Open
The tooth root and periodontal apparatus, including the acellular and cellular cementum, periodontal ligament (PDL), and alveolar bone, are critical for tooth function. Cementum and bone mineralization is regulated by factors including enz…
View article: Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in <i>Phospho1</i>–/– and <i>Phospho1/Pit1</i> Double-Knockout Mice
Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in <i>Phospho1</i>–/– and <i>Phospho1/Pit1</i> Double-Knockout Mice Open
We have previously shown that ablation of either the Phospho1 or Alpl gene, encoding PHOSPHO1 and tissue-nonspecific alkaline phosphatase (TNAP) respectively, lead to hyperosteoidosis, but that their chondrocyte-derived and osteoblast-deri…
View article: Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector
Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector Open
View article: Prevention of Lethal Murine Hypophosphatasia by Neonatal<i>Ex Vivo</i>Gene Therapy Using Lentivirally Transduced Bone Marrow Cells
Prevention of Lethal Murine Hypophosphatasia by Neonatal<i>Ex Vivo</i>Gene Therapy Using Lentivirally Transduced Bone Marrow Cells Open
Hypophosphatasia (HPP) is an inherited skeletal and dental disease caused by loss-of-function mutations in the gene that encodes tissue-nonspecific alkaline phosphatase (TNALP). The major symptoms of severe forms of the disease are bone de…
View article: The critical role of membralin in postnatal motor neuron survival and disease
The critical role of membralin in postnatal motor neuron survival and disease Open
Hitherto, membralin has been a protein of unknown function. Here, we show that membralin mutant mice manifest a severe and early-onset motor neuron disease in an autosomal recessive manner, dying by postnatal day 5–6. Selective death of lo…
View article: Author response: The critical role of membralin in postnatal motor neuron survival and disease
Author response: The critical role of membralin in postnatal motor neuron survival and disease Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Hitherto, membralin has been a protein of unkno…