Sonya Abraham
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View article: Cerebrospinal fluid haptoglobin levels and outcome after aneurysmal subarachnoid haemorrhage: Evidence from Mendelian randomization
Cerebrospinal fluid haptoglobin levels and outcome after aneurysmal subarachnoid haemorrhage: Evidence from Mendelian randomization Open
Background Subarachnoid haemorrhage (SAH) poses a life-threatening risk, contributing to half of all haemorrhagic strokes, with aneurysmal SAH (aSAH) affecting approximately 6 individuals per 100,000 annually. Following aSAH, the influx of…
View article: Advancing a Patient- and Carer-Centered Approach for the Clinical Development of New Therapeutics for Aneurysmal Subarachnoid Hemorrhage: Insights From a Qualitative Study
Advancing a Patient- and Carer-Centered Approach for the Clinical Development of New Therapeutics for Aneurysmal Subarachnoid Hemorrhage: Insights From a Qualitative Study Open
Aneurysmal subarachnoid hemorrhage (aSAH) is characterized by a high rate of fatality and high risk of secondary brain injury. More treatment options are needed to improve outcomes. There are very few reports in the medical literature invo…
View article: Automatically quantified follow-up imaging biomarkers predict clinical outcomes after acute ischemic stroke
Automatically quantified follow-up imaging biomarkers predict clinical outcomes after acute ischemic stroke Open
Background Follow-up infarct volume (FIV) is a proposed surrogate endpoint for proof-of-concept clinical studies in acute ischemic stroke (AIS). This study aimed to provide clinical validation of an automated FIV algorithm, demonstrating t…
View article: A quantitative systems pharmacology model for certolizumab pegol treatment in moderate-to-severe psoriasis
A quantitative systems pharmacology model for certolizumab pegol treatment in moderate-to-severe psoriasis Open
Background Psoriasis is a chronic immune-mediated inflammatory systemic disease with skin manifestations characterized by erythematous, scaly, itchy and/or painful plaques resulting from hyperproliferation of keratinocytes. Certolizumab pe…
View article: Covid-19 vaccine trials: Ethnic diversity and immunogenicity
Covid-19 vaccine trials: Ethnic diversity and immunogenicity Open
View article: Rare case of adult-onset phalangeal microgeodic syndrome of the feet
Rare case of adult-onset phalangeal microgeodic syndrome of the feet Open
Phalangeal microgeodic syndrome (PMS) is a rare condition typically affecting children and is characterised by painful digits precipitated by cold temperatures. In medical literature, cases appear to be clustered in Japan. Adult-onset PMS …
View article: Racial and ethnic health disparities in healthcare settings
Racial and ethnic health disparities in healthcare settings Open
The precise combination of factors responsible for the disproportionate effect of covid-19 on ethnic minority groups is likely to be complex.However, a clear message from the 4000 stakeholders taking part in Public Health England's review …
View article: Training the trainees: COVID-19 and rheumatologists of the future
Training the trainees: COVID-19 and rheumatologists of the future Open
View article: Specificity of translocator protein-targeted positron emission tomography in inflammatory joint disease
Specificity of translocator protein-targeted positron emission tomography in inflammatory joint disease Open
View article: Longitudinal profiling of the gut microbiome in patients with psoriatic arthritis and ankylosing spondylitis: a multicentre, prospective, observational study
Longitudinal profiling of the gut microbiome in patients with psoriatic arthritis and ankylosing spondylitis: a multicentre, prospective, observational study Open
View article: Telemedicine in Rheumatology at the Advent of the COVID-19 Pandemic
Telemedicine in Rheumatology at the Advent of the COVID-19 Pandemic Open
View article: Performance and Predictors of Minimal Disease Activity Response in Patients With Peripheral Spondyloarthritis Treated With Adalimumab
Performance and Predictors of Minimal Disease Activity Response in Patients With Peripheral Spondyloarthritis Treated With Adalimumab Open
Objective To examine the concurrent validity and discrimination of criteria for modified minimal disease activity (MDA) in peripheral spondyloarthritis (SpA) following filter principles of Outcome Measures in Rheumatology (OMERACT) and to …
View article: Should we be using the Covid-19 outbreak to prompt us to transform our rheumatology service delivery in the technology age?
Should we be using the Covid-19 outbreak to prompt us to transform our rheumatology service delivery in the technology age? Open
View article: Rheumatology - A Qualitative Review of Community and Hospital Based Delivery Models
Rheumatology - A Qualitative Review of Community and Hospital Based Delivery Models Open
Over recent years the increasing pressures on hospital based services has raised the question as to whether more clinical facilities can be provided in the community. Accordingly, commissioning groups have focused much of their energy towa…
View article: Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol
Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol Open
View article: THU0186 SAFETY, TOLERABILITY AND PHARMACOKINETICS OF MBS2320, A SELECTIVE MODULATOR OF IMMUNE METABOLISM, IN HEALTHY VOLUNTEERS AND PATIENTS WITH RHEUMATOID ARTHRITIS
THU0186 SAFETY, TOLERABILITY AND PHARMACOKINETICS OF MBS2320, A SELECTIVE MODULATOR OF IMMUNE METABOLISM, IN HEALTHY VOLUNTEERS AND PATIENTS WITH RHEUMATOID ARTHRITIS Open
View article: Artificial Intelligence (AI) and rheumatology: a potential partnership
Artificial Intelligence (AI) and rheumatology: a potential partnership Open
View article: Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double blind, parallel group placebo-controlled clinical trial Protocol
Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double blind, parallel group placebo-controlled clinical trial Protocol Open
Trial design: We present a study protocol for a multi-centre, randomised, double blind, parallel group, placebo-controlled trial that seeks to test the feasibility, acceptability and effectiveness of a 52-week period of treatment with the …
View article: Arthritis Prevention in the Pre-Clinical Phase of RA with Abatacept (the APIPPRA Study): A Multi-Centre, Randomised, Double Blind, Parallel Group Placebo-Controlled Clinical Trial
Arthritis Prevention in the Pre-Clinical Phase of RA with Abatacept (the APIPPRA Study): A Multi-Centre, Randomised, Double Blind, Parallel Group Placebo-Controlled Clinical Trial Open
Background: Individuals with joint pain and carrying serum autoantibodies associated with rheumatoid arthritis (RA) are at high risk of developing RA. While there are currently no evidence-based guidelines to inform therapy decisions for s…
View article: Advancing research paradigms and pathophysiological pathways in psoriatic arthritis and ankylosing spondylitis: Proceedings of the 2017 Platform for the Exchange of Expertise and Research (PEER) meeting
Advancing research paradigms and pathophysiological pathways in psoriatic arthritis and ankylosing spondylitis: Proceedings of the 2017 Platform for the Exchange of Expertise and Research (PEER) meeting Open
View article: Combined Skin and Muscle DNA Priming Provides Enhanced Humoral Responses to a Human Immunodeficency Virus Type 1 Clade C Envelope Vaccine
Combined Skin and Muscle DNA Priming Provides Enhanced Humoral Responses to a Human Immunodeficency Virus Type 1 Clade C Envelope Vaccine Open
Intradermal (i.d.) and intramuscular (i.m.) injections when administered with or without electroporation (EP) have the potential to tailor the immune response to DNA vaccination. This Phase I randomized controlled clinical trial in human i…
View article: Biologic agents in inflammatory arthritis
Biologic agents in inflammatory arthritis Open
The term ‘inflammatory arthritis’ (IA) encompasses a spectrum of diseases, of which the most common forms are rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). Over the past decade, the advent of immuno…
View article: Microflow imaging: New Doppler technology to detect low-grade inflammation in patients with arthritis
Microflow imaging: New Doppler technology to detect low-grade inflammation in patients with arthritis Open
View article: RHEUMATOID ARTHRITIS: CLINICAL FEATURES185. THE ASSOCIATION BETWEEN VITAMIN D STATUS AND INFLAMMATORY MARKERS IN PATIENTS WITH RHEUMATOID ARTHRITIS
RHEUMATOID ARTHRITIS: CLINICAL FEATURES185. THE ASSOCIATION BETWEEN VITAMIN D STATUS AND INFLAMMATORY MARKERS IN PATIENTS WITH RHEUMATOID ARTHRITIS Open
Background: There are conflicting reports on the association between vitamin D status and inflammatory markers in patients with rheumatoid arthritis.Some studies have indicated that vitamin D deficiency may be associated with increased inf…
View article: Pharmacogenomics: The Scientific Basis of Rational Drug Development and Prescribing
Pharmacogenomics: The Scientific Basis of Rational Drug Development and Prescribing Open
“It is more important to know what sort of a patient has a disease than what sort of a disease a patient has” (Hippocrates 460 BC-370 BC). The holy grail of drug discovery is to ensure that an individual responds positively to an investiga…
View article: Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis
Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis Open
View article: The evidence for microbiome manipulation in inflammatory arthritis
The evidence for microbiome manipulation in inflammatory arthritis Open
The human body consists of millions of commensal bacteria (the microbiome), with the intestinal tract being the most prevalent site of colonization. This colonization process begins at birth, and despite numerous factors such as ageing, di…
View article: Good practice in shared care for inflammatory arthritis
Good practice in shared care for inflammatory arthritis Open
Methotrexate.This has become an anchor DMARD in the treatment of inflammatory arthritis.Patients are usually initiated on 7.5-10 mg orally once weekly, increased incrementally to a maximum dose of
View article: Knowledgebase and Lifestyle Choices in Patients with Psoriatic Arthritis
Knowledgebase and Lifestyle Choices in Patients with Psoriatic Arthritis Open
To the Editor: Psoriatic arthritis (PsA) is a chronic inflammatory disease involving the skin and joints. It requires detection in primary care, subsequent referral, and initiation of management in secondary care and ongoing joint manageme…
View article: Quantitative power Doppler ultrasound measures of peripheral joint synovitis in poor prognosis early rheumatoid arthritis predict radiographic progression
Quantitative power Doppler ultrasound measures of peripheral joint synovitis in poor prognosis early rheumatoid arthritis predict radiographic progression Open
In seropositive early RA, quantitative vascular imaging by PDUS has clinical utility in predicting which patients will derive benefit from early use of biologic therapy.