Sooraj Baijnath
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View article: Deaths from suspected mothball poisoning in children
Deaths from suspected mothball poisoning in children Open
Childhood poisoning is a significant health concern in South Africa (SA), especially in densely populated informal housing settlements where children are frequently exposed to various household poisons. Poisoning accounts for 4 - 5% of pae…
View article: Oligochitosan Conjugates of the Antimalarials Dihydroartemisinin and Lumefantrine: Synthesis, Stability, Cell Viability, and Antiplasmodial Studies
Oligochitosan Conjugates of the Antimalarials Dihydroartemisinin and Lumefantrine: Synthesis, Stability, Cell Viability, and Antiplasmodial Studies Open
Malaria is treatable with several combinations of drugs, the most well‐known and currently most effective being artemisinin‐based therapies. Gastrointestinal absorption of these drugs can be poor and erratic if not taken with a fatty meal.…
View article: Potential Region-Specific Neuroprotective Effects of Kynurenine Administration in Healthy Rodents Using High-Resolution Mass Spectrometry
Potential Region-Specific Neuroprotective Effects of Kynurenine Administration in Healthy Rodents Using High-Resolution Mass Spectrometry Open
The tryptophan (TRP) metabolic pathway produces kynurenine (KYN) and serotonin (5-HT). These are important molecules in the central nervous system, as KYN plays a crucial role in neuroprotection, while 5-HT impacts mood and sleep patterns.…
View article: Regional Molecular Changes in Chronic Lipopolysaccharide-Induced Neuroinflammation
Regional Molecular Changes in Chronic Lipopolysaccharide-Induced Neuroinflammation Open
View article: Determination of Heavy Metal Contamination in Premium and Supermarket Brands of Extruded Feline and Canine Food in the South African Market
Determination of Heavy Metal Contamination in Premium and Supermarket Brands of Extruded Feline and Canine Food in the South African Market Open
The recent increase in pet food recalls due to contamination and the increased risk of disease has highlighted the need for the screening of canine and feline pelleted food. Heavy metals, an often‐overlooked contaminant, has been highlight…
View article: Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, <i>N</i>-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues
Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, <i>N</i>-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues Open
Multiomics analysis of single tissue sections using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) provides comprehensive molecular insights. However, optimizing tissue sample preparation for MALDI-MSI to…
View article: Decreased blood pressure with acute administration of quercetin in L‐NAME‐induced hypertensive rats
Decreased blood pressure with acute administration of quercetin in L‐NAME‐induced hypertensive rats Open
Quercetin is known to reduce blood pressure (BP); however, its acute effects are unclear. We investigated the acute effects of quercetin on BP, aortic mechanical properties and vascular reactivity in female Sprague–Dawley (SD) rats. Hypert…
View article: Unravelling the neuroinflammatory links in depression: the potential of a lipopolysaccharide preclinical model
Unravelling the neuroinflammatory links in depression: the potential of a lipopolysaccharide preclinical model Open
View article: Acute exposure to LPS induces cardiac dysfunction via the activation of the NLRP3 inflammasome
Acute exposure to LPS induces cardiac dysfunction via the activation of the NLRP3 inflammasome Open
Systemic inflammation contributes to left ventricular (LV) dysfunction, however the role of the NLRP3 inflammasome in LV dysfunction in acute inflammatory conditions is unclear. This study investigated the role of the NLRP3 inflammasome in…
View article: Regional Changes in Brain Biomolecular Markers in a Collagen-Induced Arthritis Rat Model
Regional Changes in Brain Biomolecular Markers in a Collagen-Induced Arthritis Rat Model Open
Background: The effects of collagen-induced arthritis (CIA), a model of systemic inflammation, on brain regional molecular markers associated with neurological disorders are uncertain. Objective: This study investigated the brain regional …
View article: Is renal dysfunction amplified in an arginine vasopressin induced rat model of preeclampsia?
Is renal dysfunction amplified in an arginine vasopressin induced rat model of preeclampsia? Open
Renal dysfunction is important in preeclampsia (PE) pathophysiology and has not been fully explored in the arginine vasopressin (AVP) rat model of PE. This study aimed to determine kidney toxicity associated with this model. Female Sprague…
View article: High Resolution Mass Spectrometry of Cystine-Containing Neuropeptides in Histological Sections of Human FFPE Tissue Banks
High Resolution Mass Spectrometry of Cystine-Containing Neuropeptides in Histological Sections of Human FFPE Tissue Banks Open
Using our earlier developed protocol, mass spectrometry imaging of small endogenous peptides (and a selection of small metabolites) can be successfully performed directly in tissue sections of formaldehyde-fixed paraffin-embedded (FFPE) sa…
View article: Neurobehavioral and molecular changes in a rodent model of ACTH-induced HPA axis dysfunction
Neurobehavioral and molecular changes in a rodent model of ACTH-induced HPA axis dysfunction Open
Hypothalamic-pituitary-adrenal (HPA) axis dysregulation is linked to the pathophysiology of depression. Although exogenous adrenocorticotropic hormone (ACTH) is associated with a depressive-like phenotype in rodents, comprehensive neurobeh…
View article: Depression, an unmet health need in Africa: Understanding the promise of ketamine
Depression, an unmet health need in Africa: Understanding the promise of ketamine Open
View article: Hesperidin improves physiological outcomes in an arginine vasopressin rat model of pre‐eclampsia
Hesperidin improves physiological outcomes in an arginine vasopressin rat model of pre‐eclampsia Open
Background Hesperidin, a flavanone commonly found in citrus fruits and herbal formulations, has emerged as a potential new therapeutic agent for modulating several diseases. Since pre‐eclampsia is a growing public health threat, it may neg…
View article: On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI–MS Imaging
On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI–MS Imaging Open
The visualization of small metabolites by MALDI mass spectrometry imaging in brain tissue sections is challenging due to low detection sensitivity and high background interference. We present an on-tissue chemical derivatization MALDI mass…
View article: The Clinical Value of Rodent Models in Understanding Preeclampsia Development and Progression
The Clinical Value of Rodent Models in Understanding Preeclampsia Development and Progression Open
Purpose of Review Preeclampsia (PE) is a leading global cause of maternal and fetal morbidity and mortality. The heterogeneity of this disorder contributes to its elusive etiology. Due to the ethical constraints surrounding human studies, …
View article: Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors
Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors Open
Virulent Enterobacterale strains expressing serine and metallo-β-lactamases (MBL) genes have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One strategy that exists is to develop β-lactamase inhibitors …
View article: In Vitro and In Vivo Development of a β-Lactam-Metallo-β-Lactamase Inhibitor: Targeting Carbapenem-Resistant <i>Enterobacterales</i>
In Vitro and In Vivo Development of a β-Lactam-Metallo-β-Lactamase Inhibitor: Targeting Carbapenem-Resistant <i>Enterobacterales</i> Open
β-lactams are the most prescribed class of antibiotics due to their potent, broad-spectrum antimicrobial activities. However, alarming rates of antimicrobial resistance now threaten the clinical relevance of these drugs, especially for the…
View article: Antioxidant and angiotensin-converting enzyme inhibitory potential of South African traditional medicinal plants and plant-derived compounds
Antioxidant and angiotensin-converting enzyme inhibitory potential of South African traditional medicinal plants and plant-derived compounds Open
Plants used in African traditional medicine to manage hypertension are potential angiotensin-converting enzyme (ACE) inhibitors. We, therefore, aimed to determine the antioxidant and anti-hypertensive properties of the methanol extracts of…
View article: Advances in spatial mass spectrometry enable in-depth neuropharmacodynamics
Advances in spatial mass spectrometry enable in-depth neuropharmacodynamics Open
Mass spectrometry imaging (MSI) is a powerful technique that combines the ability of microscopy to provide spatial information about multiple molecular species with the specificity of mass spectrometry (MS) for unlabeled mapping of analyte…
View article: The analysis of alcohol content in hand sanitisers (in the Durban region) using gas chromatography-mass spectrometry during the COVID-19 pandemic
The analysis of alcohol content in hand sanitisers (in the Durban region) using gas chromatography-mass spectrometry during the COVID-19 pandemic Open
The COVID-19 pandemic has resulted in an unprecedented surge in the demand for alcohol-based hand sanitisers (ABHS). The Centre for Disease Control (CDC) and World Health Organisation (WHO) recommend alcohol, i.e., isopropanol or ethanol, …
View article: South African medicinal plants displaying angiotensin-converting enzyme inhibition: Potential use in the management of preeclampsia
South African medicinal plants displaying angiotensin-converting enzyme inhibition: Potential use in the management of preeclampsia Open
In resource-limited settings, such as South Africa, hypertensive disorders of pregnancy such as preeclampsia, is the most common direct cause of maternal deaths. Current management strategies of preeclampsia primarily involve the use of ph…
View article: Alterations in neurotransmitter levels and transcription factor expression following intranasal buprenorphine administration
Alterations in neurotransmitter levels and transcription factor expression following intranasal buprenorphine administration Open
Buprenorphine is an opioid drug used in the management of pain and the treatment opioid addiction. Like other opioids, it is believed that it achieves these effects by altering functional neurotransmitter pathways and the expression of imp…
View article: Exploring the concerted mechanistic pathway for HIV-1 PR—substrate revealed by umbrella sampling simulation
Exploring the concerted mechanistic pathway for HIV-1 PR—substrate revealed by umbrella sampling simulation Open
HIV-1 protease (HIV-1 PR) is an essential enzyme for the replication process of its virus, and therefore considered an important target for the development of drugs against the acquired immunodeficiency syndrome (AIDS). Our previous study …
View article: “Knowledge and practices of HIV infected patients regarding medicine disposal among patients attending public ARV clinics in KwaZulu Natal, South Africa”
“Knowledge and practices of HIV infected patients regarding medicine disposal among patients attending public ARV clinics in KwaZulu Natal, South Africa” Open
Background Recent analysis of drinking water in South Africa found the presence of ARVs, other pharmaceutical and personal care products. The environmental and human health risk that this presents is daunting. The increased use of ARVs wit…
View article: Mass Spectrometric Imaging of the Brain Demonstrates the Regional Displacement of 6-Monoacetylmorphine by Naloxone
Mass Spectrometric Imaging of the Brain Demonstrates the Regional Displacement of 6-Monoacetylmorphine by Naloxone Open
Overdose is the main cause of mortality among heroin users. Many of these overdose-induced deaths can be prevented through the timely administration of naloxone (NLX), a nonselective mu (μ)-, kappa (κ)-, and delta (δ)-opioid receptor antag…
View article: A novel and more efficient biosynthesis approach for human insulin production in Escherichia coli (E. coli)
A novel and more efficient biosynthesis approach for human insulin production in Escherichia coli (E. coli) Open
View article: Mass Spectrometry Imaging Demonstrates the Regional Brain Distribution Patterns of Three First-Line Antiretroviral Drugs
Mass Spectrometry Imaging Demonstrates the Regional Brain Distribution Patterns of Three First-Line Antiretroviral Drugs Open
HIV in the central nervous system (CNS) contributes to the development of HIV-associated neurological disorders (HAND), even with chronic antiretroviral therapy. In order for antiretroviral therapy to be effective in protecting the CNS, th…
View article: CCDC 1834998: Experimental Crystal Structure Determination
CCDC 1834998: Experimental Crystal Structure Determination Open