Soosai Manickam Amirtham
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View article: Evaluation of Chondral Defect Repair Using Human Fibronectin Adhesion Assay-Derived Chondroprogenitors Suspended in Lyophilized Fetal Collagen Scaffold: An Ex Vivo Osteochondral Unit Model Study
Evaluation of Chondral Defect Repair Using Human Fibronectin Adhesion Assay-Derived Chondroprogenitors Suspended in Lyophilized Fetal Collagen Scaffold: An Ex Vivo Osteochondral Unit Model Study Open
View article: Isolated bovine pancreatic islets as an alternate <i>in vitro</i> model for diabetes research
Isolated bovine pancreatic islets as an alternate <i>in vitro</i> model for diabetes research Open
Background & objectives Isolation of functional pancreatic islets for diabetes research and clinical islet transplantation stands as a big challenge despite the advancements in the field. In this context, the non-availability of human/anim…
View article: Determination of dose-response calibration curves for gamma radiation using gamma-H2AX immunofluorescence based biodosimetry
Determination of dose-response calibration curves for gamma radiation using gamma-H2AX immunofluorescence based biodosimetry Open
BACKGROUND: Gamma-H2AX immunofluorescence assay has gained popularity as a DNA double strand break marker. In this work, we have investigated the potential use of gamma H2AX immunofluorescence assay as a biological dosimeter for estimation…
View article: Effect of reconstituted, lyophilized cold aqueous extract of Aloe vera on human whole blood clotting time - A pilot study
Effect of reconstituted, lyophilized cold aqueous extract of Aloe vera on human whole blood clotting time - A pilot study Open
View article: Effect of Cleistanthoside A on blood pressure of rats – Can vasoconstrictors help in Cleistanthus collinus poisoning?
Effect of Cleistanthoside A on blood pressure of rats – Can vasoconstrictors help in Cleistanthus collinus poisoning? Open
View article: Decellularized fetal collagen exhibits chondroinductive potential for bone marrow-derived mesenchymal stem cells by enhancing glycosaminoglycan production
Decellularized fetal collagen exhibits chondroinductive potential for bone marrow-derived mesenchymal stem cells by enhancing glycosaminoglycan production Open
Articular cartilage repair is challenging due to limited access to reparative cells and a lack of self-healing mechanisms. Bone marrow-derived mesenchymal stem cells (BM-MSCs) are a promising therapeutic option, but their tendency to form …
View article: In Vitro Human Fetal Pancreatic Islets to Redefine Pancreatic Research
In Vitro Human Fetal Pancreatic Islets to Redefine Pancreatic Research Open
Our findings showed that viable islets could be isolated and cultured in vitro for further in-depth studies to explore their proliferative potential as well as for the identification of pancreatic progenitors, a good strategy to take forwa…
View article: Human fetal cartilage-derived chondrocytes and chondroprogenitors display a greater commitment to chondrogenesis than adult cartilage resident cells
Human fetal cartilage-derived chondrocytes and chondroprogenitors display a greater commitment to chondrogenesis than adult cartilage resident cells Open
Obtaining regeneration-competent cells and generating high-quality neocartilage are still challenges in articular cartilage tissue engineering. Although chondroprogenitor cells are a resident subpopulation of native cartilage and possess a…
View article: CCDC 2093163: Experimental Crystal Structure Determination
CCDC 2093163: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Comparison of methods for the isolation and culture of Migratory chondroprogenitors from Human articular cartilage
Comparison of methods for the isolation and culture of Migratory chondroprogenitors from Human articular cartilage Open
Resident articular stem cells isolated using a migratory assay called Migratory Chondroprogenitors (MCPs) have emerged as a promising cellular therapeutic for the treatment of cartilage pathologies. In-vivo studies using MCPs report their …
View article: Assessment of the inherent chondrogenic potential of human articular cartilage-derived chondroprogenitors in pellet culture using a novel whole pellet processing approach
Assessment of the inherent chondrogenic potential of human articular cartilage-derived chondroprogenitors in pellet culture using a novel whole pellet processing approach Open
View article: Migratory chondroprogenitors retain superior intrinsic chondrogenic potential for regenerative cartilage repair as compared to human fibronectin derived chondroprogenitors
Migratory chondroprogenitors retain superior intrinsic chondrogenic potential for regenerative cartilage repair as compared to human fibronectin derived chondroprogenitors Open
View article: Rat skeletal muscle-nerve preparation to teach skeletal muscle physiology
Rat skeletal muscle-nerve preparation to teach skeletal muscle physiology Open
This sourcebook update describes a variation of a previous sourcebook experiment that used isolated extensor digitorum longus muscle from mouse to teach skeletal muscle properties (Head SI, Arber MS. Adv Physiol Educ 37: 405–414, 2013). Ga…
View article: Prospective Isolation and Characterization of Chondroprogenitors from Human Chondrocytes Based on CD166/CD34/CD146 Surface Markers
Prospective Isolation and Characterization of Chondroprogenitors from Human Chondrocytes Based on CD166/CD34/CD146 Surface Markers Open
Purpose Chondrocytes, isolated from articular cartilage, are routinely utilized in cell-based therapeutics for the treatment of cartilage pathologies. However, restoration of the biological tissue faces hindrance due to the formation of pr…
View article: Elusive Toxin in <i>Cleistanthus collinus</i> Causing Vasoconstriction and Myocardial Depression: Detailed NMR Analyses and Biological Studies of Cleistanthoside A
Elusive Toxin in <i>Cleistanthus collinus</i> Causing Vasoconstriction and Myocardial Depression: Detailed NMR Analyses and Biological Studies of Cleistanthoside A Open
Cleistanthus collinus leaf extracts are consumed for suicidal purposes in southern India. The boiled decoction is known to be more toxic than the fresh leaf juice. Although several compounds have been isolated and their toxicity tes…
View article: Correction: Phenylephrine induces relaxation of longitudinal strips from small arteries of goat legs
Correction: Phenylephrine induces relaxation of longitudinal strips from small arteries of goat legs Open
[This corrects the article DOI: 10.1371/journal.pone.0227316.].
View article: Supplemental Information S14: Fatigue and recovery experiment LabChart data file
Supplemental Information S14: Fatigue and recovery experiment LabChart data file Open
LabChart data file of fatigue and recovery experiment. The file can be opened by using LabChart reader provided freely by ADInstruments, Australia at https://www.adinstruments.com/products/labchart-reader.
View article: Supplemental Information S11: Effect of two successive stimulation experiment LabChart data file
Supplemental Information S11: Effect of two successive stimulation experiment LabChart data file Open
LabChart data file of effect of two successive stimulation experiment. The file can be opened using LabChart reader software provided freely by ADInstruments, Australia at https://www.adinstruments.com/products/labchart-reader.
View article: Supplemental Information S15: Fatigue and recovery experiment LabChart data file
Supplemental Information S15: Fatigue and recovery experiment LabChart data file Open
LabChart data file of fatigue and recovery experiment. The file can be opened by using LabChart reader provided freely by ADInstruments, Australia at https://www.adinstruments.com/products/labchart-reader.
View article: Supplemental Information S12: Tetanus experiment LabChart data file
Supplemental Information S12: Tetanus experiment LabChart data file Open
LabChart data file of tetanus experiment. The file can be opened using LabChart reader provided freely by ADInstruments, Australia at https://www.adinstruments.com/products/labchart-reader.
View article: Supplemental Information S13: Treppe experiment LabChart data file
Supplemental Information S13: Treppe experiment LabChart data file Open
LabChart data file of treppe experiment. The file can be opened by using LabChart reader provided freely by ADInstruments, Australia at https://www.adinstruments.com/products/labchart-reader.
View article: Supplemental Information S11: Quantal summation LabChart data file
Supplemental Information S11: Quantal summation LabChart data file Open
LabChart data file of quantal summation experiment. The file can be opened using LabChart reader provided freely by ADInstruments, Australia at: https://www.adinstruments.com/products/labchart-reader.
View article: Supplemental Information S13: Tetanus experiment LabChart data file
Supplemental Information S13: Tetanus experiment LabChart data file Open
LabChart data file of tetanus experiment. The file can be opened using LabChart reader provided freely by ADInstruments, Australia at https://www.adinstruments.com/products/labchart-reader.
View article: Supplemental Information S14: Treppe experiment LabChart data file
Supplemental Information S14: Treppe experiment LabChart data file Open
LabChart data file of treppe experiment. The file can be opened by using LabChart reader provided freely by ADInstruments, Australia at https://www.adinstruments.com/products/labchart-reader.
View article: Supplemental Information S16: Length-tension relationship experiment LabChart data file
Supplemental Information S16: Length-tension relationship experiment LabChart data file Open
LabChart data file of length-tension relationship experiment. The file can be opened using LabChart reader provided freely by ADInstruments, Australia at https://www.adinstruments.com/products/labchart-reader.
View article: Supplemental Information S9: Simple muscle twitch LabChart data file
Supplemental Information S9: Simple muscle twitch LabChart data file Open
LabChart data file of simple muscle twitch. The file can be opened using LabChart reader provided freely by ADInstruments, Australia at: https://www.adinstruments.com/products/labchart-reader
View article: Supplemental Information S12: Effect of two successive stimulation experiment LabChart data file
Supplemental Information S12: Effect of two successive stimulation experiment LabChart data file Open
LabChart data file of effect of two successive stimulation experiment. The file can be opened using LabChart reader software provided freely by ADInstruments, Australia at https://www.adinstruments.com/products/labchart-reader. The inter-p…
View article: Supplemental Information S10: Quantal summation LabChart data file
Supplemental Information S10: Quantal summation LabChart data file Open
LabChart data file of quantal summation experiment. The file can be opened using LabChart reader provided freely by ADInstruments, Australia at: https://www.adinstruments.com/products/labchart-reader.
View article: Supplemental Information S9: Simple muscle twitch LabChart data file
Supplemental Information S9: Simple muscle twitch LabChart data file Open
LabChart data file of simple muscle twitch experiment. The file can be opened using LabChart reader provided freely by ADInstruments, Australia at: https://www.adinstruments.com/products/labchart-reader.