Explanipedia

Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolution Open

Kami Pekayvaz, Badr Kilani, Markus Joppich, Luke Eivers, Sophia Brambs , et al. · 2025

Thrombotic diseases remain the major cause of death and disability worldwide, and the contribution of inflammation is increasingly recognized. Thromboinflammation has been identified as a key pathomechanism, but an unsupervised map of immu…

Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis Open

Markus Joppich, Kami Pekayvaz, Sophia Brambs, Viktoria Knottenberg, Luke Eivers , et al. · 2025

Original Data for the manuscript: Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolution The manuscript is accessible at https://doi.org/10.1016/j.immuni.20…

Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes Open

Kami Pekayvaz, Corinna Losert, Viktoria Knottenberg, Christoph Gold, Irene V. van Blokland , et al. · 2024

Acute and chronic coronary syndromes (ACS and CCS) are leading causes of mortality. Inflammation is considered a key pathogenic driver of these diseases, but the underlying immune states and their clinical implications remain poorly unders…

Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis Open

Kami Pekayvaz, Markus Joppich, Sophia Brambs, Viktoria Knottenberg, Luke Eivers , et al. · 2024

Thrombotic diseases remain the major cause of death and disability worldwide with insufficient preventive and therapeutic strategies available. In the last decades a prominent inflammatory component has been identified as a key driver in t…

Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis Open

Markus Joppich, Kami Pekayvaz, Sophia Brambs, Viktoria Knottenberg, Luke Eivers , et al. · 2024

<div>\n<h2>Original Data for the manuscript:</h2>\n<h2>Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis</h2>\n</div>\n<div>The manuscript is access…

Multi-Omic Factor Analysis uncovers immunological signatures with pathophysiologic and clinical implications in coronary syndromes Open

Kami Pekayvaz, Corinna Losert, Viktoria Knottenberg, Irene V. van Blokland, Roy Oelen , et al. · 2023

Acute and chronic coronary syndromes (ACS and CCS) are leading causes of mortality. Inflammation is considered to be a key pathogenic driver, but immune states in humans and their clinical implications remain poorly understood. We hypothes…

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection Open

Kami Pekayvaz, Alexander Leunig, Rainer Kaiser, Markus Joppich, Sophia Brambs , et al. · 2022

Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19 Open

Rainer Kaiser, Alexander Leunig, Kami Pekayvaz, Oliver Popp, Markus Joppich , et al. · 2021

Neutrophils provide a critical line of defense in immune responses to various pathogens, inflicting self-damage upon transition to a hyperactivated, procoagulant state. Recent work has highlighted proinflammatory neutrophil phenotypes cont…

Vascular neutrophilic inflammation and immunothrombosis distinguish severe COVID‐19 from influenza pneumonia Open

Leo Nicolai, Alexander Leunig, Sophia Brambs, Rainer Kaiser, Markus Joppich , et al. · 2020

Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy Open

Leo Nicolai, Alexander Leunig, Sophia Brambs, Rainer Kaiser, Tobias Weinberger , et al. · 2020

Background: Severe acute respiratory syndrome corona virus 2 infection causes severe pneumonia (coronavirus disease 2019 [COVID-19]), but the mechanisms of subsequent respiratory failure and complicating renal and myocardial involvement ar…

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