Sophia Chikhladze
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View article: The distance to arteries predicts the oncological outcome in pancreatic cancer surgery – results from a 3D reconstruction model
The distance to arteries predicts the oncological outcome in pancreatic cancer surgery – results from a 3D reconstruction model Open
Measurement of the distance to the closest artery in preoperative imaging has strong prognostic value for recurrence and overall survival in patients with resectable PDAC.
View article: InPaFis – results of an open monocenter single-arm phase II study to evaluate the safety of a modified analgesia with indomethacin during pancreatectomy and its influence on clinically relevant postoperative pancreatic fistula
InPaFis – results of an open monocenter single-arm phase II study to evaluate the safety of a modified analgesia with indomethacin during pancreatectomy and its influence on clinically relevant postoperative pancreatic fistula Open
Background: Clinically relevant postoperative pancreatic fistula (CR-POPF) is a common complication after pancreatoduodenectomies, probably caused by local inflammation around the pancreas anastomosis. During endoscopic retrograde cholangi…
View article: Editorial: The microbiome in surgery - friend or foe?
Editorial: The microbiome in surgery - friend or foe? Open
View article: Microbiological colonization of the pancreatic tumor affects postoperative complications and outcome after pancreatic surgery
Microbiological colonization of the pancreatic tumor affects postoperative complications and outcome after pancreatic surgery Open
Background The patient´s microbiome has become a focal point in cancer research. Even for pancreatic cancer, alterations in the microbiome appear to influence cancer formation and progression. The aim of our single-center analysis was the …
View article: Preoperative prediction of postoperative pancreatic fistula after Pancreaticoduodenectomy: Determination and validation of a cut-off value for the Roberts Score
Preoperative prediction of postoperative pancreatic fistula after Pancreaticoduodenectomy: Determination and validation of a cut-off value for the Roberts Score Open
The scoring variables and the cut-off itself were both independent predictors, which may improve the identification of high-risk patients and help to investigate the development of POPF.
View article: Elderly male patient presenting with jaundice and cholangitis brings an unexpected histopathological finding, case report
Elderly male patient presenting with jaundice and cholangitis brings an unexpected histopathological finding, case report Open
In this report, we present a case of the first-time manifestation of Langerhans cell histiocytosis in the biliary tract of a 79-year-old male patient. Cholangiocarcinoma was the suspected diagnosis, based on the patient's painless jaundice…
View article: Separation of small extracellular vesicles (sEV) from human blood by Superose 6 size exclusion chromatography
Separation of small extracellular vesicles (sEV) from human blood by Superose 6 size exclusion chromatography Open
Extracellular vesicles (EVs) are valuable targets for liquid biopsy. However, attempts to introduce EV‐based biomarkers into clinical practice have not been successful to the extent expected. One of the reasons for this failure is the lack…
View article: Oncological survival in pancreatic head ductal carcinoma: hybrid minimally invasive versus open pancreatoduodenectomy – a single centre analysis
Oncological survival in pancreatic head ductal carcinoma: hybrid minimally invasive versus open pancreatoduodenectomy – a single centre analysis Open
Background: Surgery remains the only curative treatment option for pancreatic head cancer. Laparoscopic surgical techniques are increasingly used, in line with the development of visceral surgery as a whole. The success of surgery is measu…
View article: Multiple surgical revisions in patients with anastomotic leakage: A retrospective cohort analysis
Multiple surgical revisions in patients with anastomotic leakage: A retrospective cohort analysis Open
The occurrence of an anastomotic leakage is a serious and potentially life-threatening complication in visceral surgery, affecting up to 20% of patients with a newly created gastrointestinal anastomosis. Most patients with anastomotic leak…
View article: Pancreatic head resection for carcinoma of the ampulla vateri – better long-term prognosis, but more postoperative complications
Pancreatic head resection for carcinoma of the ampulla vateri – better long-term prognosis, but more postoperative complications Open
View article: Surgical complications requiring late surgical revisions after pancreatoduodenectomy increase postoperative morbidity and mortality
Surgical complications requiring late surgical revisions after pancreatoduodenectomy increase postoperative morbidity and mortality Open
Background: Pancreatoduodenectomies are complex surgical procedures with considerable postoperative morbidity and mortality. Here, we describe complications and outcomes in patients requiring surgical revisions following pancreatoduodenect…
View article: Immune changes induced by periampullary adenocarcinoma are reversed after tumor resection and modulate the postoperative survival
Immune changes induced by periampullary adenocarcinoma are reversed after tumor resection and modulate the postoperative survival Open
View article: Surgical pancreatic biopsies for cases with locally advanced pancreatic cancer with inconclusive histology after interventional biopsy
Surgical pancreatic biopsies for cases with locally advanced pancreatic cancer with inconclusive histology after interventional biopsy Open
Laparoscopic and open surgical biopsies in patients with unresectable pancreatic cancer demonstrate a high diagnostic sensitivity at acceptable complication rates. This finding is important because it provides further support for surgical …
View article: Immune changes induced by periampullary adenocarcinoma are reversed after tumor resection and modulate the postoperative survival
Immune changes induced by periampullary adenocarcinoma are reversed after tumor resection and modulate the postoperative survival Open
Background Tumor growth encompasses multiple immunologic processes leading to impaired immunity. Regarding cancer surgery, the perioperative period is characterized by an additional immunosuppression that may contribute to poor outcomes. I…
View article: Perioperative risk of pancreatic head resection—nomogram-based prediction of severe postoperative complications as a decisional aid for clinical practice
Perioperative risk of pancreatic head resection—nomogram-based prediction of severe postoperative complications as a decisional aid for clinical practice Open
Purpose To develop nomograms for pre- and early-postoperative risk assessment of patients undergoing pancreatic head resection. Methods Clinical data from 956 patients were collected in a prospectively maintained database. A test ( n = 772…
View article: Molecular Mechanisms of Tumor Immunomodulation in the Microenvironment of Colorectal Cancer
Molecular Mechanisms of Tumor Immunomodulation in the Microenvironment of Colorectal Cancer Open
Colorectal cancer remains one of the most important health challenges in our society. The development of cancer immunotherapies has fostered the need to better understand the anti-tumor immune mechanisms at play in the tumor microenvironme…
View article: The clinical impact of preoperative biliary drainage on isolated infectious complications (iiC) after pancreatic head resection—a retrospective study
The clinical impact of preoperative biliary drainage on isolated infectious complications (iiC) after pancreatic head resection—a retrospective study Open
Background The perioperative morbidity after pancreatoduodenectomy (PD) is mostly influenced by intraabdominal complications which are often associated with infections. In patients with preoperative biliary drainage (PBD), the risk for pos…
View article: Clinical characteristics and outcome of patients with acute mesenteric ischemia: a retrospective cohort analysis
Clinical characteristics and outcome of patients with acute mesenteric ischemia: a retrospective cohort analysis Open
View article: High serum CA19–9 preoperatively reduces POPF risk after pancreatoduodenectomy in PDAC
High serum CA19–9 preoperatively reduces POPF risk after pancreatoduodenectomy in PDAC Open
Background: Recent groundbreaking work revealed CA19–9 is not only a tumor marker for PDAC. It also induces severe pancreatitis and promotes pancreatic fibrosis. The aim of this study was evaluation if due fibrosis CA19–9 may stratify for …
View article: Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery—A Narrative Review
Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery—A Narrative Review Open
Postoperative complications are a major problem occurring in up to 50% of patients undergoing major abdominal surgery. Occurrence of postoperative complications is associated with a significantly higher morbidity and mortality in affected …
View article: Pancreatic Resection in Older Patients: A Retrospective Single-Center Outcome Analysis
Pancreatic Resection in Older Patients: A Retrospective Single-Center Outcome Analysis Open
Due to increasing life expectancy and improved diagnostic sensitivity, a growing number of older patients are presenting with resectable pancreatic disease entities and are being evaluated for surgery. Intended as an internal quality contr…
View article: Curative-intent pancreas resection for pancreatic metastases: surgical and oncological results
Curative-intent pancreas resection for pancreatic metastases: surgical and oncological results Open
Background Pancreatic metastasis is a rare cause for pancreas surgery and often a sign of advanced disease no chance of curative-intent treatment. However, surgery for metastasis might be a promising approach to improve patients’ survival.…
View article: Sclerosing angiomatoid nodular transformation of the spleen, a rare cause for splenectomy: Two case reports
Sclerosing angiomatoid nodular transformation of the spleen, a rare cause for splenectomy: Two case reports Open
SANT is a rare cause of splenectomy and an incidental histological finding. Further research should focus on clinical and radiological diagnosis of SANT as well as on treatment of patients with asymptomatic and small findings.
View article: Adjuvant chemotherapy after surgery for pancreatic ductal adenocarcinoma: retrospective real-life data
Adjuvant chemotherapy after surgery for pancreatic ductal adenocarcinoma: retrospective real-life data Open
View article: The rate of postoperative pancreatic fistula after distal pancreatectomy is independent of the pancreatic stump closure technique – A retrospective analysis of 284 cases
The rate of postoperative pancreatic fistula after distal pancreatectomy is independent of the pancreatic stump closure technique – A retrospective analysis of 284 cases Open
View article: Bio‐absorbable sealants for reinforcing the pancreatic stump after distal pancreatectomy are critical
Bio‐absorbable sealants for reinforcing the pancreatic stump after distal pancreatectomy are critical Open
Background Bio‐absorbable sealants are widely used to reduce the rate and severity of postoperative pancreatic fistulas after distal pancreatectomy. However, numerous clinical trials have failed to demonstrate their clinical benefit. We th…
View article: Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA)
Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA) Open
Objective: The aim of this study was to compare oncological outcomes after minimally invasive distal pancreatectomy (MIDP) with open distal pancreatectomy (ODP) in patients with pancreatic ductal adenocarcinoma (PDAC). Background: Cohort s…
View article: The prognostic influence of intrapancreatic tumor location on survival after resection of pancreatic ductal adenocarcinoma
The prognostic influence of intrapancreatic tumor location on survival after resection of pancreatic ductal adenocarcinoma Open
Patients with resectable pancreatic ductal adenocarcinoma located in the body and tail of the pancreas display a similar postoperative oncological outcome despite larger tumors when compared to patients with resectable tumors located in th…
View article: The chemokine ligand CXCL16 is an indicator of bacterial infection in necrotizing pancreatitis
The chemokine ligand CXCL16 is an indicator of bacterial infection in necrotizing pancreatitis Open
Serum CXCL16 is increased in severe pancreatitis with infected pancreatic necrosis and identifies patients who benefit from surgical necrosectomy.