Sophia Gessner
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View article: Culture filtrate selectively promotes <i>Mycobacterium tuberculosis</i> growth from extremely low density inocula: implications for quantifying differentially culturable phenotypes
Culture filtrate selectively promotes <i>Mycobacterium tuberculosis</i> growth from extremely low density inocula: implications for quantifying differentially culturable phenotypes Open
Differentially culturable (DC) Mycobacterium tuberculosis ( Mtb ) phenotypes reduce the sensitivity of sputum culture and may be associated with adverse treatment outcomes among tuberculosis patients. Accurately quantifying DC Mtb remains …
View article: The RecA-NT homology motif in ImuB mediates the interaction with ImuA′, which is essential for DNA damage–induced mutagenesis
The RecA-NT homology motif in ImuB mediates the interaction with ImuA′, which is essential for DNA damage–induced mutagenesis Open
The mycobacterial mutasome-comprising ImuA', ImuB, and DnaE2-has been implicated in DNA damage-induced mutagenesis in Mycobacterium tuberculosis. ImuB, which is predicted to enable mutasome function via its interaction with the β clamp, is…
View article: Persistent Mycobacterium tuberculosis bioaerosol release in a tuberculosis-endemic setting
Persistent Mycobacterium tuberculosis bioaerosol release in a tuberculosis-endemic setting Open
Pioneering studies linking symptomatic disease and cough-mediated Mycobacterium tuberculosis (Mtb) release established the infectious origin of tuberculosis (TB), simultaneously informing the notion that pathology is a prerequisite for Mtb…
View article: Persistent<i>Mycobacterium tuberculosis</i>bioaerosol release in a tuberculosis-endemic setting
Persistent<i>Mycobacterium tuberculosis</i>bioaerosol release in a tuberculosis-endemic setting Open
Pioneering studies linking symptomatic disease and cough-mediated release of Mycobacterium tuberculosis ( Mtb ) established the infectious origin of tuberculosis (TB), simultaneously informing the pervasive notion that pathology is a prere…
View article: Aerosolization of viable <i>Mycobacterium tuberculosis</i> bacilli by tuberculosis clinic attendees independent of sputum-Xpert Ultra status
Aerosolization of viable <i>Mycobacterium tuberculosis</i> bacilli by tuberculosis clinic attendees independent of sputum-Xpert Ultra status Open
Potential Mycobacterium tuberculosis ( Mtb ) transmission during different pulmonary tuberculosis (TB) disease states is poorly understood. We quantified viable aerosolized Mtb from TB clinic attendees following diagnosis and through six m…
View article: Investigating the composition and recruitment of the mycobacterial ImuA′–ImuB–DnaE2 mutasome
Investigating the composition and recruitment of the mycobacterial ImuA′–ImuB–DnaE2 mutasome Open
A DNA damage-inducible mutagenic gene cassette has been implicated in the emergence of drug resistance in Mycobacterium tuberculosis during anti-tuberculosis (TB) chemotherapy. However, the molecular composition and operation of the encode…
View article: RecA-NT homology motif in ImuB is essential for mycobacterial ImuA’-ImuB protein interaction and mutasome function
RecA-NT homology motif in ImuB is essential for mycobacterial ImuA’-ImuB protein interaction and mutasome function Open
The mycobacterial mutasome – minimally comprising ImuA’, ImuB, and DnaE2 proteins – has been implicated in DNA damage-induced mutagenesis in Mycobacterium tuberculosis . ImuB, predicted to enable mutasome function via its interaction with …
View article: Author response: Investigating the composition and recruitment of the mycobacterial ImuA′–ImuB–DnaE2 mutasome
Author response: Investigating the composition and recruitment of the mycobacterial ImuA′–ImuB–DnaE2 mutasome Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract A DNA d…
View article: Aerosolization of viable<i>Mycobacterium tuberculosis</i>bacilli by tuberculosis clinic attendees independent of sputum-GeneXpert status
Aerosolization of viable<i>Mycobacterium tuberculosis</i>bacilli by tuberculosis clinic attendees independent of sputum-GeneXpert status Open
The potential for bioaerosol release of Mycobacterium tuberculosis ( Mtb ) during different tuberculosis (TB) disease states is poorly understood. We quantified viable aerosolized Mtb from presumptive TB patients on diagnosis and, thereaft…
View article: Aerosolization of <i>Mycobacterium tuberculosis</i> by Tidal Breathing
Aerosolization of <i>Mycobacterium tuberculosis</i> by Tidal Breathing Open
Rationale: Interrupting tuberculosis (TB) transmission requires an improved understanding of how and when the causative organism, Mycobacterium tuberculosis (Mtb), is aerosolized. Although cough is commonly assumed to be the dominant sourc…
View article: Non-Volatile Organic Compounds in Exhaled Breath Particles Correspond to Active Tuberculosis
Non-Volatile Organic Compounds in Exhaled Breath Particles Correspond to Active Tuberculosis Open
Human breath contains trace amounts of non-volatile organic compounds (NOCs) which might inform non-invasive methods for evaluation of individual health. In previous work, we demonstrated that lipids detected in exhaled breath aerosol (EBA…
View article: The mycobacterial mutasome: composition and recruitment in live cells
The mycobacterial mutasome: composition and recruitment in live cells Open
A DNA damage-inducible mutagenic gene cassette has been implicated in the emergence of drug resistance in Mycobacterium tuberculosis during anti-tuberculosis (TB) chemotherapy. However, the molecular composition and operation of the encode…
View article: Aerosolization of <i>Mycobacterium tuberculosis</i> by tidal breathing
Aerosolization of <i>Mycobacterium tuberculosis</i> by tidal breathing Open
Rationale Interrupting tuberculosis (TB) transmission requires an improved understanding of how – and when – the causative organism, Mycobacterium tuberculosis ( Mtb ), is aerosolized. Although Cough is commonly assumed to be the dominant …
View article: Capture and visualization of live Mycobacterium tuberculosis bacilli from tuberculosis patient bioaerosols
Capture and visualization of live Mycobacterium tuberculosis bacilli from tuberculosis patient bioaerosols Open
Interrupting transmission is an attractive anti-tuberculosis (TB) strategy but it remains underexplored owing to our poor understanding of the events surrounding transfer of Mycobacterium tuberculosis ( Mtb ) between hosts. Determining whe…
View article: Cough-independent production of viable Mycobacterium tuberculosis in bioaerosol
Cough-independent production of viable Mycobacterium tuberculosis in bioaerosol Open
Peripheral lung bioaerosol released through deep exhalations alone contained viable Mtb suggesting non-cough transmission is possible in PTB.
View article: Sensitivity optimisation of tuberculosis bioaerosol sampling
Sensitivity optimisation of tuberculosis bioaerosol sampling Open
This study demonstrates that technical improvements in particle collection together with sensitive detection enable rapid quantitation of viable Mtb in bioaerosols of sputum positive TB cases. Increased sampling sensitivity may allow futur…
View article: Sensitivity Optimisation of Tuberculosis Bioaerosol Sampling
Sensitivity Optimisation of Tuberculosis Bioaerosol Sampling Open
Introduction Detection of Mycobacterium tuberculosis ( Mtb ) in patient-derived bioaerosol is a potential tool to measure source case infectiousness. However, current bioaerosol sampling approaches have reported low detection yields in spu…
View article: Capture and visualization of live<i>Mycobacterium tuberculosis</i>bacilli from tuberculosis bioaerosols
Capture and visualization of live<i>Mycobacterium tuberculosis</i>bacilli from tuberculosis bioaerosols Open
The tuberculosis (TB) pandemic demands urgent interventions such as those designed to interrupt Mycobacterium tuberculosis ( Mtb ) transmission, a challenge exacerbated by our poor understanding of the events enabling successful transfer o…
View article: Neuroinflammatory demyelinating diseases CNS Common Data Elements
Neuroinflammatory demyelinating diseases CNS Common Data Elements Open
Common Data Elements for Neuroinflammatory Demyelinating Diseases of the central nervous system (NID CDEs). The NID CDEs may be used in clinical routine, clinical trial and registry documentation of Multiple Sclerosis (MS), Neuromyelitis O…
View article: Molecular mechanisms of DNA repair in Mycobacterium tuberculosis
Molecular mechanisms of DNA repair in Mycobacterium tuberculosis Open
The mycobacterial DNA damage and repair pathways involved in the emergence of drug-resistance during host infection remain poorly understood, yet are critical to any efforts to develop novel "anti-evolution" drugs aimed at reducing the cap…