Sophia Krombholz
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View article: The influence of the route of drug administration on the metabolic profile of trenbolone in doping control urine samples
The influence of the route of drug administration on the metabolic profile of trenbolone in doping control urine samples Open
Advances in analytical techniques have markedly improved the detection of anabolic-androgenic steroids (AAS) in doping controls. This represents a major success for anti-doping efforts, but at the same times raises concerns about inadverte…
View article: Carbon isotope ratios of phenethylamine and its urinary metabolite phenylacetylglutamine
Carbon isotope ratios of phenethylamine and its urinary metabolite phenylacetylglutamine Open
Phenethylamine (PEA) is a naturally occurring trace amine that acts as a modulator in the central nervous system. It is widely sold as a dietary supplement and advertised for its mood enhancing effects and should support weight loss. It is…
View article: Insulin‐mimetic peptides in sports drug testing
Insulin‐mimetic peptides in sports drug testing Open
Because of its influence on carbohydrate metabolism and, at the same time, anti‐catabolic effects, the misuse of the peptide hormone insulin and its synthetic analogs is prohibited in sports at all times according to the regulations of the…
View article: Vancomycin Concentrations in Synovial Fluid Do Not Reach Chondrotoxic Thresholds After Anterior Cruciate Ligament Reconstruction With Vancomycin-Soaked Autologous Soft Tissue Grafts: An In Vivo Prospective Observational Study in Humans
Vancomycin Concentrations in Synovial Fluid Do Not Reach Chondrotoxic Thresholds After Anterior Cruciate Ligament Reconstruction With Vancomycin-Soaked Autologous Soft Tissue Grafts: An In Vivo Prospective Observational Study in Humans Open
Background: Studies have revealed that vancomycin soaking of the anterior cruciate ligament (ACL) graft can drastically reduce the incidence of postoperative infections after ACL reconstruction. However, it remains unknown whether the chon…
View article: Investigations into the In Vitro Metabolism of hGH and IGF-I Employing Stable-Isotope-Labelled Drugs and Monitoring Diagnostic Immonium Ions by High-Resolution/High-Accuracy Mass Spectrometry
Investigations into the In Vitro Metabolism of hGH and IGF-I Employing Stable-Isotope-Labelled Drugs and Monitoring Diagnostic Immonium Ions by High-Resolution/High-Accuracy Mass Spectrometry Open
Studying the metabolism of prohibited substances is an essential element in anti-doping research in order to facilitate and improve detectability. Whilst pharmacokinetic studies on healthy volunteers are valuable, they are often difficult,…
View article: Urinary phenylethylamine metabolites as potential markers for sports drug testing purposes
Urinary phenylethylamine metabolites as potential markers for sports drug testing purposes Open
The misuse of 2‐phenylethylamine (PEA) in sporting competitions is prohibited by the World Anti‐Doping Agency. As it is endogenously produced, a method is required to differentiate between naturally elevated levels of PEA and the illicit a…