Sophia Lavrentiadou
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View article: Reproductive Effects of Endocrine Disruptors in Domestic Ruminants: Integrating In Vitro and In Vivo Evidence
Reproductive Effects of Endocrine Disruptors in Domestic Ruminants: Integrating In Vitro and In Vivo Evidence Open
Endocrine-disrupting chemicals (EDCs) have raised increasing concern due to their potential effects on reproductive health. This review focuses on the impact of EDCs, particularly bisphenol A (BPA) and its analogues, and per- and polyfluor…
View article: Neuroprotective, Antioxidant and Anti-Inflammatory Effect of Greek Pomegranate Seed Oil on N2a Neuroblastoma Cells and Mild Cognitive Impairment Patients
Neuroprotective, Antioxidant and Anti-Inflammatory Effect of Greek Pomegranate Seed Oil on N2a Neuroblastoma Cells and Mild Cognitive Impairment Patients Open
Alzheimer’s disease (AD) remains a significant global health challenge with limited FDA-approved treatments, necessitating the search for novel preventive strategies. Antioxidants that are present in fruits and vegetables have garnered att…
View article: Supplementing Freezing Medium with Crocin Exerts a Protective Effect on Bovine Spermatozoa Through the Modulation of a Heat Shock-Mediated Apoptotic Pathway
Supplementing Freezing Medium with Crocin Exerts a Protective Effect on Bovine Spermatozoa Through the Modulation of a Heat Shock-Mediated Apoptotic Pathway Open
The supplementation of freezing medium with crocin results in an amelioration of post-thawing sperm quality, as determined by motility and viability. This study aimed to examine the molecular mechanisms underlying the ameliorative effect o…
View article: Evaluation of the Anti-Amyloid and Anti-Inflammatory Properties of a Novel Vanadium(IV)–Curcumin Complex in Lipopolysaccharides-Stimulated Primary Rat Neuron-Microglia Mixed Cultures
Evaluation of the Anti-Amyloid and Anti-Inflammatory Properties of a Novel Vanadium(IV)–Curcumin Complex in Lipopolysaccharides-Stimulated Primary Rat Neuron-Microglia Mixed Cultures Open
Lipopolysaccharides (LPS) are bacterial mediators of neuroinflammation that have been detected in close association with pathological protein aggregations of Alzheimer’s disease. LPS induce the release of cytokines by microglia and mediate…
View article: Treatment with Pterostilbene Ameliorates the Antioxidant Status of Bovine Spermatozoa and Modulates Cell Death Pathways
Treatment with Pterostilbene Ameliorates the Antioxidant Status of Bovine Spermatozoa and Modulates Cell Death Pathways Open
Reactive Oxygen Species (ROS) play an important role in sperm physiology. They are required in processes such as capacitation and fertilization. However, the exposure of spermatozoa to ROS generated from internal or external sources may cr…
View article: The Role of Erythropoietin in Bovine Sperm Physiology
The Role of Erythropoietin in Bovine Sperm Physiology Open
Erythropoietin (EPO), a hormone secreted mainly by the kidney, exerts its biological function by binding to its cell-surface receptor (EpoR). The presence of EPO and EpoR in the male and female reproductive system has been verified. Theref…
View article: Melatonin Protects Bovine Spermatozoa by Reinforcing Their Antioxidant Defenses
Melatonin Protects Bovine Spermatozoa by Reinforcing Their Antioxidant Defenses Open
Cryopreserved semen is widely used in assisted reproductive techniques. Post-thawing spermatozoa endure oxidative stress due to the high levels of reactive oxygen and nitrogen species, which are produced during the freezing/thawing process…
View article: Melatonin Protects Bovine Spermatozoa by Reinforcing Their Antioxidant Defenses
Melatonin Protects Bovine Spermatozoa by Reinforcing Their Antioxidant Defenses Open
Cryopreserved semen is widely used in Assisted Reproductive Technologies (ART) enabling the conservation and broad use of genetically superior semen. The quality of semen post-thawing determines the success of ART and despite the great adv…
View article: The Beneficial Effects of Pterostilbene on Post-Thawed Bovine Spermatozoa
The Beneficial Effects of Pterostilbene on Post-Thawed Bovine Spermatozoa Open
Reactive Oxygen Species (ROS), primarily produced by cellular metabolism, are highly reactive molecules that modify cellular compounds. During sperm preparation in Assisted Reproductive Techniques (ARTs), intrinsic and extrinsic sources of…
View article: In vitro and in silico evaluation of the anti-amyloid and anti-inflammatory properties of curcumin and a V (IV) – curcumin complex in LPS-stimulated primary rat neurons-microglia mixed cultures
In vitro and in silico evaluation of the anti-amyloid and anti-inflammatory properties of curcumin and a V (IV) – curcumin complex in LPS-stimulated primary rat neurons-microglia mixed cultures Open
Lipopolysaccharides (LPS) of Gram-negative bacteria are mediators of neuroinflammation and neurodegeneration that have been detected in close association with aggregations of brain amyloid beta (Aβ) and microtubule-associated protein tau (…
View article: Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic rats
Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic rats Open
View article: Additional file 1 of Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic rats
Additional file 1 of Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic rats Open
Additional file 1. Altogether data for JBR.
View article: O ρόλος των ενεργοποιών του πλασμινογόνου και της πλασμίνης στην αναπαραγωγή των θηλαστικών
O ρόλος των ενεργοποιών του πλασμινογόνου και της πλασμίνης στην αναπαραγωγή των θηλαστικών Open
The current knowledge of the role of local and directed fibrinolysis controlled by plasminogen activators (PAs) and regulated by plasminogen activator inhibitors (PAls) in reproduction is summarized. The PA system has been found to play an…
View article: Protective effect of crocetin on bovine spermatozoa against oxidative stress during in vitro fertilization
Protective effect of crocetin on bovine spermatozoa against oxidative stress during in vitro fertilization Open
Summary Oxidative stress is one of the major factors that contribute to poor semen quality and low rates of in vitro fertilization. Crocetin, a main constituent of saffron ( Crocus sativus L.) possesses potent antioxidant activity, by scav…