Sophie A. Kitchen
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View article: Hemoglobin stability impact on healthcare resource utilization and costs among dialysis-dependent patients with anemia of end-stage kidney disease
Hemoglobin stability impact on healthcare resource utilization and costs among dialysis-dependent patients with anemia of end-stage kidney disease Open
View article: Association between a publicly funded universal drug program and antipsychotic and antidepressant medication dispensing to children
Association between a publicly funded universal drug program and antipsychotic and antidepressant medication dispensing to children Open
View article: Patterns in the Diagnosis and Management of Early Alzheimer’s Disease in Community‐Based Settings in the United States
Patterns in the Diagnosis and Management of Early Alzheimer’s Disease in Community‐Based Settings in the United States Open
Background With the changing care landscape for early Alzheimer’s disease (AD), optimizing the diagnostic and management process is key. This study assessed the correlation between patient and physician characteristics and outcomes related…
View article: Unmet Needs in the Diagnosis and Management of Early AD in Community‐Based Settings in the United States
Unmet Needs in the Diagnosis and Management of Early AD in Community‐Based Settings in the United States Open
Background Disparities in the quality and timeliness of care for Alzheimer’s disease (AD) are well documented. This study assessed the impact of demographic characteristics on the diagnosis and management of early AD patients in community‐…
View article: Long-Term Temporal Trends of Real-World Healthcare Costs Associated with Nivolumab Plus Ipilimumab and Pembrolizumab Plus Axitinib as First-Line Treatment for Advanced or Metastatic Renal Cell Carcinoma
Long-Term Temporal Trends of Real-World Healthcare Costs Associated with Nivolumab Plus Ipilimumab and Pembrolizumab Plus Axitinib as First-Line Treatment for Advanced or Metastatic Renal Cell Carcinoma Open
View article: Varying circumstances surrounding opioid toxicity deaths across ethno-racial groups in Ontario, Canada: a population-based descriptive cross-sectional study
Varying circumstances surrounding opioid toxicity deaths across ethno-racial groups in Ontario, Canada: a population-based descriptive cross-sectional study Open
Introduction The North American toxic drug crisis has been framed as an epidemic primarily affecting white people. However, evidence suggests that deaths are rising among racialised people. Accordingly, we sought to describe and compare ch…
View article: Impact of a publicly-funded pharmacare program policy on benzodiazepine dispensing among children and youth: a population-based natural experiment
Impact of a publicly-funded pharmacare program policy on benzodiazepine dispensing among children and youth: a population-based natural experiment Open
View article: Use of injections for chronic pain from 2010 to 2019 in Ontario, Canada
Use of injections for chronic pain from 2010 to 2019 in Ontario, Canada Open
View article: Clinical outcomes and health care costs among people entering a safer opioid supply program in Ontario
Clinical outcomes and health care costs among people entering a safer opioid supply program in Ontario Open
Although additional research is needed, this preliminary evidence indicates that SOS programs can play an important role in the expansion of treatment and harm-reduction options available to assist people who use drugs and who are at high …
View article: Responding to Ontario’s Overdose Crisis in the Context of the COVID-19 Pandemic
Responding to Ontario’s Overdose Crisis in the Context of the COVID-19 Pandemic Open
The COVID-19 pandemic has exacerbated the overdose crisis in Canada. Using data from ICES and the Office of the Chief Coroner of Ontario, the authors characterized changing patterns of medication use and health services utilization during …
View article: Effectiveness of a fourth dose of covid-19 mRNA vaccine against the omicron variant among long term care residents in Ontario, Canada: test negative design study
Effectiveness of a fourth dose of covid-19 mRNA vaccine against the omicron variant among long term care residents in Ontario, Canada: test negative design study Open
Objectives To estimate the marginal effectiveness of a fourth versus third dose and the vaccine effectiveness of mRNA covid-19 vaccines BNT162b2 and mRNA-1273 against any infection, symptomatic infection, and severe outcomes (hospital admi…
View article: Effectiveness of a Fourth Dose of COVID-19 Vaccine among Long-Term Care Residents in Ontario, Canada: Test-Negative Design Study
Effectiveness of a Fourth Dose of COVID-19 Vaccine among Long-Term Care Residents in Ontario, Canada: Test-Negative Design Study Open
Background As of December 30, 2021, Ontario long-term care (LTC) residents who received a third dose of COVID-19 vaccine ≥84 days previously were offered a fourth dose to prevent a surge in COVID-19-related morbidity and mortality due to t…
View article: Impact of the COVID-19 pandemic on the prevalence of opioid agonist therapy discontinuation in Ontario, Canada: A population-based time series analysis
Impact of the COVID-19 pandemic on the prevalence of opioid agonist therapy discontinuation in Ontario, Canada: A population-based time series analysis Open
View article: Vaccine effectiveness of BNT162b2 against Omicron and Delta outcomes in adolescents
Vaccine effectiveness of BNT162b2 against Omicron and Delta outcomes in adolescents Open
Introduction Data on vaccine effectiveness (VE) against Omicron in adolescents are limited. We estimated 2-dose and 3-dose VE against Omicron and Delta in adolescents aged 12-17 years in Ontario, Canada. Methods We conducted a test-negativ…
View article: Association Between Increased Dispensing of Opioid Agonist Therapy Take-Home Doses and Opioid Overdose and Treatment Interruption and Discontinuation
Association Between Increased Dispensing of Opioid Agonist Therapy Take-Home Doses and Opioid Overdose and Treatment Interruption and Discontinuation Open
In Ontario, Canada, during the COVID-19 pandemic, dispensing of increased take-home doses of opioid agonist therapy was significantly associated with lower rates of treatment interruption and discontinuation among some subsets of patients …
View article: Impact of the COVID-19 pandemic on the provision of take-home doses of opioid agonist therapy in Ontario, Canada: A population-based time-series analysis
Impact of the COVID-19 pandemic on the provision of take-home doses of opioid agonist therapy in Ontario, Canada: A population-based time-series analysis Open
View article: The effects of COVID‐19 on the dispensing rates of antidepressants and benzodiazepines in Canada
The effects of COVID‐19 on the dispensing rates of antidepressants and benzodiazepines in Canada Open
Despite the increased reporting of depressive and anxious symptoms during the COVID-19 pandemic, there have been no changes in the dispensing trends of medications used to treat these disorders. As the pandemic continues to evolve, future …
View article: Trends in Hospitalizations for Serious Infections Among People With Opioid Use Disorder in Ontario, Canada
Trends in Hospitalizations for Serious Infections Among People With Opioid Use Disorder in Ontario, Canada Open
Objectives Opioid use among people who inject drugs can lead to serious complications, including infections. We sought to study trends in rates of these complications among people with an opioid use disorder (OUD) and the sequelae of those…
View article: The impact of proposed regulatory changes and rescheduling on low-dose codeine purchasing in Canada: a time-series analysis
The impact of proposed regulatory changes and rescheduling on low-dose codeine purchasing in Canada: a time-series analysis Open
Although Health Canada's 2016 announcement of a proposed regulatory change did not appear to have an effect on OTC codeine purchasing nationally, the 60-day comment period was associated with a decrease in purchasing. Further, Manitoba's 2…
View article: Projected impact of biosimilar substitution policies on drug use and costs in Ontario, Canada: a cross-sectional time series analysis
Projected impact of biosimilar substitution policies on drug use and costs in Ontario, Canada: a cross-sectional time series analysis Open
Policies designed to curb rising costs of biologics can have substantially different effects on patients and government expenditures. Such analyses warrant careful consideration of the balance between cost savings and effects on patients.
View article: Measuring the Burden of Opioid-Related Mortality in Ontario, Canada, During the COVID-19 Pandemic
Measuring the Burden of Opioid-Related Mortality in Ontario, Canada, During the COVID-19 Pandemic Open
This cross-sectional study quantifies the added burden of fatal opioid overdoses during the first 6 months of the COVID-19 pandemic in Ontario, Canada.
View article: Effect of listing strategies on utilization of antitumor necrosis factor biologics infliximab and etanercept: a cross-sectional analysis from Ontario, Canada
Effect of listing strategies on utilization of antitumor necrosis factor biologics infliximab and etanercept: a cross-sectional analysis from Ontario, Canada Open
BACKGROUND: Use of costly biologic drugs for the treatment of chronic inflammatory diseases has increased significantly in recent years. However, biosimilar drugs offer an opportunity to ensure health system sustainability with robu…
View article: Emergency department-based medication review on outpatient health services utilization: interrupted time series
Emergency department-based medication review on outpatient health services utilization: interrupted time series Open
View article: LO27: Risk factors for misuse of prescribed opioids: a systematic review and meta-analysis
LO27: Risk factors for misuse of prescribed opioids: a systematic review and meta-analysis Open
View article: Evaluating the effect of pharmacist-led medication review in high-risk emergency department patients on health services utilization
Evaluating the effect of pharmacist-led medication review in high-risk emergency department patients on health services utilization Open
Background One in nine emergency department (ED) visits in Canada are caused by adverse drug events, the unintended and harmful effects of medication use. Medication reviews by clinical pharmacists are interventions designed to optimize me…