Sophie Camp
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View article: Standardisation of Convex Ultrasound Data Through Geometric Analysis and Augmentation
Standardisation of Convex Ultrasound Data Through Geometric Analysis and Augmentation Open
The application of ultrasound in healthcare has seen increased diversity and importance. Unlike other medical imaging modalities, ultrasound research and development has historically lagged, particularly in the case of applications with da…
View article: Deep Learning-Based Glioma Segmentation of 2D Intraoperative Ultrasound Images: A Multicenter Study Using the Brain Tumor Intraoperative Ultrasound Database (BraTioUS)
Deep Learning-Based Glioma Segmentation of 2D Intraoperative Ultrasound Images: A Multicenter Study Using the Brain Tumor Intraoperative Ultrasound Database (BraTioUS) Open
Background: Intraoperative ultrasound (ioUS) provides real-time imaging during neurosurgical procedures, with advantages such as portability and cost-effectiveness. Accurate tumor segmentation has the potential to substantially enhance the…
View article: A method for mimicking tumour tissue in brain ex-vivo ultrasound for research application and clinical training
A method for mimicking tumour tissue in brain ex-vivo ultrasound for research application and clinical training Open
Background Intraoperative ultrasound is becoming a common tool in neurosurgery. However, effective simulation methods are limited. Current, commercial, and homemade phantoms lack replication of anatomical correctness and texture complexity…
View article: Intraoperative superb microvascular ultrasound imaging in glioma: novel quantitative analysis correlates with tumour grade
Intraoperative superb microvascular ultrasound imaging in glioma: novel quantitative analysis correlates with tumour grade Open
Accurate grading of gliomas is critical to guide therapy and predict prognosis. The presence of microvascular proliferation is a hallmark feature of high grade gliomas which traditionally requires targeted surgical biopsy of representative…
View article: Clinical practice guidelines for the care of patients with a chronic subdural haematoma: multidisciplinary recommendations from presentation to recovery
Clinical practice guidelines for the care of patients with a chronic subdural haematoma: multidisciplinary recommendations from presentation to recovery Open
We present the first multidisciplinary guideline for the care of patients with cSDH. The recommendations reflect a paradigm shift in the care of cSDH, recognising and formalising the need for multidisciplinary and collaborative clinical ma…
View article: A Method For Mimicking Tumour Tissue In Brain Ex-Vivo Ultrasound For Research Application And Clinical Training
A Method For Mimicking Tumour Tissue In Brain Ex-Vivo Ultrasound For Research Application And Clinical Training Open
Background Intraoperative ultrasound is becoming a common tool in neurosurgery. However, effective simulation methods are limited. Current, commercial, and homemade phantoms lack replication of anatomical correctness and texture complexity…
View article: Clinical practice guidelines for the care of patients with a chronic subdural haematoma: multidisciplinary recommendations from presentation to recovery
Clinical practice guidelines for the care of patients with a chronic subdural haematoma: multidisciplinary recommendations from presentation to recovery Open
Introduction A cSDH is an encapsulated collection of fluid and blood degradation products in the subdural space. It is increasingly common, affecting older people and those living with frailty. Currently, no guidance exists to define optim…
View article: Imaging timing after surgery for glioblastoma: an evaluation of practice in Great Britain and Ireland (INTERVAL-GB)- a multi-centre, cohort study
Imaging timing after surgery for glioblastoma: an evaluation of practice in Great Britain and Ireland (INTERVAL-GB)- a multi-centre, cohort study Open
Purpose Post-operative MRI is used to assess extent of resection, monitor treatment response and detect progression in high-grade glioma. However, compliance with accepted guidelines for follow-up MRI, and impact on management/outcomes is …
View article: Challenges With Segmenting Intraoperative Ultrasound For Brain Tumours
Challenges With Segmenting Intraoperative Ultrasound For Brain Tumours Open
Objective Addressing the challenges that come with identifying and delineating brain tumours in intraoperative ultrasound. Our goal is to both qualitatively and quantitatively assess the interobserver variation, amongst experienced neuro-o…
View article: Towards Safe and Collaborative Robotic Ultrasound Tissue Scanning in Neurosurgery
Towards Safe and Collaborative Robotic Ultrasound Tissue Scanning in Neurosurgery Open
Intraoperative ultrasound imaging is used to facilitate safe brain tumour resection. However, due to challenges with image interpretation and the physical scanning, this tool has yet to achieve widespread adoption in neurosurgery. In this …
View article: Protocol for the development of a multidisciplinary clinical practice guideline for the care of patients with chronic subdural haematoma
Protocol for the development of a multidisciplinary clinical practice guideline for the care of patients with chronic subdural haematoma Open
Introduction: A common neurosurgical condition, chronic subdural haematoma (cSDH) typically affects older people with other underlying health conditions. The care of this potentially vulnerable cohort is often, however, fragmented and subo…
View article: P11.03.A DOES REGULAR SURVEILLANCE IMAGING IMPROVE SURVIVAL IN GLIOBLASTOMA? RESULTS FROM A NATIONAL, MULTI-CENTRE COHORT STUDY (INTERVAL-GB)
P11.03.A DOES REGULAR SURVEILLANCE IMAGING IMPROVE SURVIVAL IN GLIOBLASTOMA? RESULTS FROM A NATIONAL, MULTI-CENTRE COHORT STUDY (INTERVAL-GB) Open
BACKGROUND Glioblastoma is the most common malignant primary brain tumour in adults and is usually incurable. Post-operative magnetic resonance imaging (MRI) is used to assess extent of resection, and subsequent follow-up MRI is used to mo…
View article: Identifying visible tissue in intraoperative ultrasound: a method and application
Identifying visible tissue in intraoperative ultrasound: a method and application Open
Purpose: Intraoperative ultrasound scanning is a demanding visuotactile task. It requires operators to simultaneously localise the ultrasound perspective and manually perform slight adjustments to the pose of the probe, making sure not to …
View article: Automated robotic intraoperative ultrasound for brain surgery
Automated robotic intraoperative ultrasound for brain surgery Open
During brain tumour resection, localising cancerous tissue and delineating healthy and pathological borders is challenging, even for experienced neurosurgeons and neuroradiologists. Intraoperative imaging is commonly employed for determini…
View article: Collaborative Robotic Ultrasound Tissue Scanning for Surgical Resection Guidance in Neurosurgery
Collaborative Robotic Ultrasound Tissue Scanning for Surgical Resection Guidance in Neurosurgery Open
The aim of this paper is to introduce a robotic platform for autonomous iUS tissue scanning to optimise intraoperative diagnosis and improve surgical resection during robot-assisted operations. To guide anatomy specific robotic scanning an…
View article: FUTURE-GB: functional and ultrasound-guided resection of glioblastoma – a two-stage randomised control trial
FUTURE-GB: functional and ultrasound-guided resection of glioblastoma – a two-stage randomised control trial Open
Introduction Surgery remains the mainstay for treatment of primary glioblastoma, followed by radiotherapy and chemotherapy. Current standard of care during surgery involves the intraoperative use of image-guidance and 5-aminolevulinic acid…
View article: Challenges and opportunities in the care of chronic subdural haematoma: perspectives from a multi-disciplinary working group on the need for change
Challenges and opportunities in the care of chronic subdural haematoma: perspectives from a multi-disciplinary working group on the need for change Open
The care of cSDH is a growing clinical problem. Lessons may be learned from the standardised pathways of care such as those as used in hip fracture and stroke. A defined care pathway for cSDH, encompassing perioperative care and rehabilita…
View article: Improved Prediction of Surgical Resectability in Patients with Glioblastoma using an Artificial Neural Network
Improved Prediction of Surgical Resectability in Patients with Glioblastoma using an Artificial Neural Network Open
In managing a patient with glioblastoma (GBM), a surgeon must carefully consider whether sufficient tumour can be removed so that the patient can enjoy the benefits of decompression and cytoreduction, without impacting on the patient’s neu…
View article: Imaging and Tissue Biomarkers of Choline Metabolism in Diffuse Adult Glioma: 18F-Fluoromethylcholine PET/CT, Magnetic Resonance Spectroscopy, and Choline Kinase α
Imaging and Tissue Biomarkers of Choline Metabolism in Diffuse Adult Glioma: 18F-Fluoromethylcholine PET/CT, Magnetic Resonance Spectroscopy, and Choline Kinase α Open
The cellular and molecular basis of choline uptake on PET imaging and MRS-visible choline-containing compounds is not well understood. Choline kinase alpha (ChoKα) is an enzyme that phosphorylates choline, an essential step in membrane syn…
View article: Real-world experience with Temozolomide & Sativex in patients with recurrent High Grade Gliomas
Real-world experience with Temozolomide & Sativex in patients with recurrent High Grade Gliomas Open
Background Glioblastoma (GBM) is the most common malignant brain tumour in adults with a median survival from progression of 8 months. A recent phase 1 study of temozolomide (TMZ) and 1:1 CBD:THC (Sativex) offers evidence of efficacy in pa…
View article: Factors affecting treatment strategy, completion of planned treatment and survival in older patients with glioblastoma
Factors affecting treatment strategy, completion of planned treatment and survival in older patients with glioblastoma Open
Introduction For older patients with glioblastoma (GBM), age, extent of resection, and performance status are prognostic factors. However, an international survey conducted by our Unit found that >40% of neurosurgeons use age alone to disc…
View article: Using Neuro-oncology to teach GCSE students STEM-subjects
Using Neuro-oncology to teach GCSE students STEM-subjects Open
Background The profile of brain tumours in the wider community has recently been raised. In this project we explored whether we could link brain tumour awareness with STEM education for secondary school pupils. We aimed to inspire the next…
View article: Factors affecting patient flow in a neurosurgery department
Factors affecting patient flow in a neurosurgery department Open
Introduction Patient flow is the process by which movement of patients and clinical productivity is achieved. The objectives of this study were to implement and evaluate the NHS Improvement SAFER patient flow bundle, evaluate the impact of…