Sophie Curio
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View article: Roux-en-Y gastric bypass-associated fecal tyramine promotes colon cancer risk via increased DNA damage, cell proliferation, and inflammation
Roux-en-Y gastric bypass-associated fecal tyramine promotes colon cancer risk via increased DNA damage, cell proliferation, and inflammation Open
View article: Tyramine promotes colon cancer risk and development by inducing DNA damage and inflammation
Tyramine promotes colon cancer risk and development by inducing DNA damage and inflammation Open
High dietary consumption of processed meat is associated with increased colorectal cancer (CRC) risk, but mechanistic links remain largely unknown. Tyramine is a biogenic amine found in processed food and a gut bacterial product from tyros…
View article: NKG2D Fine-Tunes the Local Inflammatory Response in Colorectal Cancer
NKG2D Fine-Tunes the Local Inflammatory Response in Colorectal Cancer Open
Treating colorectal cancer (CRC) is a major challenge due to the heterogeneous immunological, clinical and pathological landscapes. Immunotherapy has so far only proven effective in a very limited subgroup of CRC patients. To better define…
View article: The unique role of innate lymphoid cells in cancer and the hepatic microenvironment
The unique role of innate lymphoid cells in cancer and the hepatic microenvironment Open
Cancer is a complex disease, and despite incredible progress over the last decade, it remains the leading cause of death worldwide. Liver cancers, including hepatocellular carcinoma (HCC), and liver metastases are distinct from other cance…
View article: NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression
NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression Open
γδT cells are unconventional T cells particularly abundant in mucosal tissues that play an important role in tissue surveillance, homeostasis, and cancer. γδT cells recognize stressed cells or cancer cells through the NKG2D receptor to kil…
View article: NKG2D signaling regulates IL-17A-producing γδT cells to promote cancer progression
NKG2D signaling regulates IL-17A-producing γδT cells to promote cancer progression Open
γδT cells are unconventional T cells particularly abundant in mucosal tissues that play an important role in tissue surveillance and homeostasis. γδT cell activation is mediated by the T cell receptor composed of γ and δ chains, as well as…
View article: A summary of current NKG2D-based CAR clinical trials
A summary of current NKG2D-based CAR clinical trials Open
Summary Cancer immunotherapies have significantly improved patient survival and treatment options in recent years. Nonetheless, the success of immunotherapy is limited to certain cancer types and specific subgroups of patients, making the …