Sophie Lemmens
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View article: Conventional probe trabeculotomy versus microcatheter-assisted 360° trabeculotomy (PIRATE) in childhood glaucoma—study protocol for a randomized controlled trial
Conventional probe trabeculotomy versus microcatheter-assisted 360° trabeculotomy (PIRATE) in childhood glaucoma—study protocol for a randomized controlled trial Open
View article: Imaging modalities in optic disc drusen: A literature review and proposed diagnostic algorithm
Imaging modalities in optic disc drusen: A literature review and proposed diagnostic algorithm Open
Optic disc drusen (ODD) concern highly prevalent anatomical features that are increasingly recognised as a risk factor for various pathological conditions. In clinical practice, differentiation between ODD and true papilloedema poses consi…
View article: Ab externo Schlemm’s canal surgery: Efficacy and safety outcomes
Ab externo Schlemm’s canal surgery: Efficacy and safety outcomes Open
The purpose of this article is to review the existing literature on the efficacy and safety of ab externo viscocanalostomy (VCS) and canaloplasty (CP) in glaucoma patients. A literature search was conducted, following the Preferred Reporti…
View article: Acute corneal edema and residual subepithelial haze after bilateral selective laser trabeculoplasty: A case series
Acute corneal edema and residual subepithelial haze after bilateral selective laser trabeculoplasty: A case series Open
The primary objective of this case series is to report three cases of acute corneal edema and subepithelial haze occurring shortly after bilateral selective laser trabeculoplasty (SLT). SLT was performed to treat open-angle glaucoma in thr…
View article: Reversal of cup-to-disc ratio following trabeculectomy using optical coherence tomography imaging: A case series
Reversal of cup-to-disc ratio following trabeculectomy using optical coherence tomography imaging: A case series Open
In this case series, we report the reversal of optic disc cupping in three adults following trabeculectomy. Two patients experienced asymptomatic low intraocular pressure (IOP) postoperatively, while the third patient had intermittently el…
View article: Visual field patterns in glaucoma: A systematic review
Visual field patterns in glaucoma: A systematic review Open
The aim of this literature study is to investigate the specific visual field defects for each glaucoma subtype and evaluate their pattern of progression. A systematic search was performed in accordance with the PRISMA guidelines in Medline…
View article: Home iCare – What we already know
Home iCare – What we already know Open
The only known modifiable risk factor for the development and progression of glaucoma is an increased intraocular pressure (IOP). Current follow-up with Goldmann applanation tonometry (GAT) constitutes a suboptimal approach, given out-of-o…
View article: Outcomes of microcatheter-assisted trabeculotomy in adult patients with primary congenital glaucoma and juvenile open-angle glaucoma: A case series
Outcomes of microcatheter-assisted trabeculotomy in adult patients with primary congenital glaucoma and juvenile open-angle glaucoma: A case series Open
Trabeculotomy is conventionally performed using a rigid probe, allowing for 180° trabeculotomy. More recently, microcatheter-assisted 360° trabeculotomy (MCAT) has shown safe and effective results in pediatric glaucoma cases, particularly …
View article: Treatment Outcomes Comparing the Paul and Baerveldt Glaucoma Implants After One Year of Follow-Up
Treatment Outcomes Comparing the Paul and Baerveldt Glaucoma Implants After One Year of Follow-Up Open
Précis: In reducing intraocular pressure (IOP), Paul (PGI) and Baerveldt (BGI) glaucoma implants are safe and effective in patients with glaucoma. Objective: To compare efficacy and safety profiles of the PGI and BGI in the treatment of me…
View article: Differentiating ischemic optic neuropathy from glaucoma using diagnostic tests
Differentiating ischemic optic neuropathy from glaucoma using diagnostic tests Open
Introduction: Anterior ischemic optic neuropathy (AION) can mimic glaucoma and consequently cause difficulties in differential diagnosis. The purpose of this paper is to summarize differences in diagnostic tests that can help perform a cor…
View article: Supplementary Material for: Differentiating ischemic optic neuropathy from glaucoma using diagnostic tests
Supplementary Material for: Differentiating ischemic optic neuropathy from glaucoma using diagnostic tests Open
Introduction: Anterior ischemic optic neuropathy (AION) can mimic glaucoma and consequently cause difficulties in differential diagnosis. The purpose of this paper is to summarize differences in diagnostic tests that can help perform a cor…
View article: Supplementary Material for: Differentiating ischemic optic neuropathy from glaucoma using diagnostic tests
Supplementary Material for: Differentiating ischemic optic neuropathy from glaucoma using diagnostic tests Open
Introduction: Anterior ischemic optic neuropathy (AION) can mimic glaucoma and consequently cause difficulties in differential diagnosis. The purpose of this paper is to summarize differences in diagnostic tests that can help perform a cor…
View article: Supplementary Material for: Differentiating ischemic optic neuropathy from glaucoma using diagnostic tests
Supplementary Material for: Differentiating ischemic optic neuropathy from glaucoma using diagnostic tests Open
Introduction: Anterior ischemic optic neuropathy (AION) can mimic glaucoma and consequently cause difficulties in differential diagnosis. The purpose of this paper is to summarize differences in diagnostic tests that can help perform a cor…
View article: The eye as a window to the brain: hyperspectral retinal imaging as a biomarker for Alzheimer’s disease
The eye as a window to the brain: hyperspectral retinal imaging as a biomarker for Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is a neurodegenerative disorder that is the leading cause of dementia, affecting more than 50 million people worldwide. In the search for new biomarkers, increasing attention has been dedicated to the re…
View article: A retinal tauopathy with a characteristic molecular pattern points to the existence of a “Primary retinal tauopathy”
A retinal tauopathy with a characteristic molecular pattern points to the existence of a “Primary retinal tauopathy” Open
Background Pathogenic processes characteristic of neurodegenerative brain diseases, such as accumulation of phosphorylated Tau protein (pTau), can also be detected in the retina. Given the advanced state of retinal imaging technology and i…
View article: Primary retinal tauopathy: A tauopathy with a distinct molecular pattern
Primary retinal tauopathy: A tauopathy with a distinct molecular pattern Open
BACKGROUND Phosphorylated tau (p‐tau) accumulation, a hallmark of Alzheimer's disease (AD), can also be found in the retina. However, it is uncertain whether it is linked to AD or another tauopathy. METHODS Retinas from 164 individuals, wi…
View article: Stages of retinal tauopathy and its relation to age and non‐AD retinal pathologies
Stages of retinal tauopathy and its relation to age and non‐AD retinal pathologies Open
Background Retinal imaging for Alzheimer’s disease (AD) pathological features is a potential biomarker for AD. Amyloid β‐protein (Aβ) containing plaques and abnormally phosphorylated tau (p‐tau) pathology have been reported in retinas of A…
View article: The effect of citicoline oral solution on quality of life in patients with glaucoma: the results of an international, multicenter, randomized, placebo-controlled cross-over trial
The effect of citicoline oral solution on quality of life in patients with glaucoma: the results of an international, multicenter, randomized, placebo-controlled cross-over trial Open
View article: Management of Childhood Glaucoma Following Cataract Surgery
Management of Childhood Glaucoma Following Cataract Surgery Open
Glaucoma remains a frequent serious complication following cataract surgery in children. The optimal approach to management for ‘glaucoma following cataract surgery’ (GFCS), one of the paediatric glaucoma subtypes, is an ongoing debate. Th…
View article: Age‐related changes in the fractal dimension of the retinal microvasculature, effects of cardiovascular risk factors and smoking behaviour
Age‐related changes in the fractal dimension of the retinal microvasculature, effects of cardiovascular risk factors and smoking behaviour Open
Purpose This cross‐sectional study investigates the association between retinal vessel complexity and age and studies the effects of cardiovascular health determinants. Methods Retinal vessel complexity was assessed by calculating the box‐…
View article: Comparative retinal imaging in mouse models of proteinopathies identifies disease-specific biomarkers
Comparative retinal imaging in mouse models of proteinopathies identifies disease-specific biomarkers Open
View article: The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research
The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research Open
View article: Patient creates filtering bleb: hypotony following traumatic rupture of an old scleral incision for intracapsular cataract surgery
Patient creates filtering bleb: hypotony following traumatic rupture of an old scleral incision for intracapsular cataract surgery Open
An 86-year-old woman presented with symptomatic hypotony on the left eye since a few weeks, blurry vision and a very sensitive eye. She had a history of bilateral intracapsular cataract extraction (ICCE) in 1982 and secondary intraocular l…
View article: Combination of snapshot hyperspectral retinal imaging and optical coherence tomography to identify Alzheimer’s disease patients
Combination of snapshot hyperspectral retinal imaging and optical coherence tomography to identify Alzheimer’s disease patients Open
View article: The Prevalence of Undiagnosed Age-Related Sight-Threatening Diseases in Self-Proclaimed Healthy Individuals
The Prevalence of Undiagnosed Age-Related Sight-Threatening Diseases in Self-Proclaimed Healthy Individuals Open
Background. Age-related conditions such as glaucoma, age-related macular degeneration, diabetic retinopathy, and cataract have become the major cause of visual impairment and blindness in high-income countries. The aim of the current study…
View article: Hyperspectral Imaging and the Retina: Worth the Wave?
Hyperspectral Imaging and the Retina: Worth the Wave? Open
Given the promising results that smaller studies show for hyperspectral imaging (e.g., in Alzheimer's disease), advanced research in larger validation studies is warranted to determine its true clinical potential.
View article: The<i>App</i><sup><i>NL-G-F</i></sup>mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research
The<i>App</i><sup><i>NL-G-F</i></sup>mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research Open
In this study, we report the results of a comprehensive phenotyping of the retina of the App NL-G-F mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progresses to Aβ plaque formati…
View article: Systematic Review on Fractal Dimension of the Retinal Vasculature in Neurodegeneration and Stroke: Assessment of a Potential Biomarker
Systematic Review on Fractal Dimension of the Retinal Vasculature in Neurodegeneration and Stroke: Assessment of a Potential Biomarker Open
Introduction: Ocular manifestations in several neurological pathologies accentuate the strong relationship between the eye and the brain. Retinal alterations in particular can serve as surrogates for cerebral changes. Offering a "wi…
View article: The prevalence of undiagnosed age-related sight threatening diseases in self-proclaimed healthy individuals
The prevalence of undiagnosed age-related sight threatening diseases in self-proclaimed healthy individuals Open
Background Age-related conditions such as glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DRP) and cataract have become the major cause of visual impairment and blindness in high-income countries and carry a major s…
View article: Accurate prediction of glaucoma from colour fundus images with a convolutional neural network that relies on active and transfer learning
Accurate prediction of glaucoma from colour fundus images with a convolutional neural network that relies on active and transfer learning Open
Purpose To assess the use of deep learning ( DL ) for computer‐assisted glaucoma identification, and the impact of training using images selected by an active learning strategy, which minimizes labelling cost. Additionally, this study focu…