Explanipedia

Polymicrobial Pyogenic Liver Abscess Without Classical Risk Factors: A Case Report of Streptococcus constellatus and Fusobacterium nucleatum Infection Open

D. W. Barron, Susan Wallace, Douglas E Rappaport, James Kelley, Wayne A Martini · 2025

Pyogenic liver abscesses are uncommon, often polymicrobial, and can be fatal if left untreated, with a mortality rate of 5-15%. Established risk factors include diabetes mellitus, hepatobiliary disease, malignancy, recent abdominal surgery…

In-silico trials of targeted screening for abdominal aortic aneurysms using linked healthcare data: A study protocol Open

Liam Musto, Athanasios Saratzis, Mintu Nath, Emmanuel Katsogridakis, Ann Elsworth , et al. · 2025

Background The NHS abdominal aortic aneurysm (AAA) screening programme (NAAASP) is both clinically and economically effective. One of the main determinants of this effectiveness is disease prevalence. AAA prevalence is decreasing over time…

Emerging and evolving values in the changing landscape of genomics Open

Maria Siermann, Riya Mohan, Eline M. Bunnik, Anne Cambon‐Thomsen, Ruth Chadwick , et al. · 2025

Recent advances in human genomics have transformed the field, leading to increased integration of genomics into mainstream clinical care, broadening the potential of personalized medicine, and expanding data generation and sharing. From th…

The research relationship: participant perspectives on consent in biobanking Open

Rachel Thompson, Kate Lyle, Gabrielle Samuel, Jo Holliday, Fenella Starkey , et al. · 2025

Background This paper examines challenges associated with the governance of large-scale biobanks. As the collection and interrogation of population-scale data is increasingly positioned as a route to new understandings of health and diseas…

Whither Consent in Clinical Genetics? Open

Susan Wallace · 2024

The research relationship: participant perspectives on consent in biobanking Open

Rachel Thompson, Kate Lyle, Gabrielle Samuel, Jo Holliday, Fenella Starkey , et al. · 2024

Background: This paper examines the ethical challenges associated with the governance of large-scale biobanks. As the collection and interrogation of population-scale data is increasingly positioned as the route to new understandings of he…

Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease Open

Alexander T. Williams, Jing Chen, Kayesha Coley, Chiara Batini, Abril G. Izquierdo , et al. · 2023

Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease susceptibility and age-of-onset Open

Alexander T. Williams, Jing Chen, Kayesha Coley, Chiara Batini, Abril G. Izquierdo , et al. · 2022

Thyroid hormones play a critical role in regulation of multiple physiological functions and thyroid dysfunction is associated with substantial morbidity. Electronic health records were used to undertake the largest genome-wide association …

Extended Cohort for E-health, Environment and DNA (EXCEED) COVID-19 focus Open

Paul H. Lee, Anna L. Guyatt, Catherine John, Altaf Ali, Xueyang Wang , et al. · 2021

Background: New data collection in established longitudinal population studies provides an opportunity for studying the risk factors and sequelae of the novel coronavirus disease 2019 (COVID-19), plus the indirect impacts of the COVID-19 p…

Adding dynamic consent to a longitudinal cohort study: A qualitative study of EXCEED participant perspectives Open

Susan Wallace, José Miola · 2021

How Can We Not Waste Legacy Genomic Research Data? Open

Susan Wallace, Emily Kirby, Bartha Maria Knoppers · 2020

Enabling genomic and biomedical data to be shared for secondary research purposes is not always straightforward for existing "legacy" data sets. Researchers may not know whether their data meet ethical and regulatory requirements for shari…

Potential for diagnosis of infectious disease from the 100,000 Genomes Project Metagenomic Dataset: Recommendations for reporting results Open

Gkikas Magiorkinis, Philippa C. Matthews, Susan Wallace, Katie Jeffery, Kevin Dunbar , et al. · 2019

The identification of microbiological infection is usually a diagnostic investigation, a complex process that is firstly initiated by clinical suspicion. With the emergence of high-throughput sequencing (HTS) technologies, metagenomic anal…

Corrigendum to: Cohort profile: Extended Cohort for E-health, Environment and DNA (EXCEED) Open

Catherine John, Nicola Reeve, Robert C. Free, Alexander T. Williams, Ioanna Ntalla , et al. · 2019

This is a correction to: International Journal of Epidemiology, Volume 48, Issue 3, June 2019, Pages 678–679j, https://doi.org/10.1093/ije/dyz073

Cohort Profile: Extended Cohort for E-health, Environment and DNA (EXCEED) Open

Catherine John, Nicola Reeve, Robert C. Free, Alexander T. Williams, Ioanna Ntalla , et al. · 2019

Participants have consented to their pseudonymized data being made available to other approved researchers, and we welcome requests for collaboration and data access. Access to the resource requires completion of a proposal form, including…

Cohort Profile: Extended Cohort for E-health, Environment and DNA (EXCEED) Open

Catherine John, Nicola Reeve, Robert C. Free, Alexander T. Williams, Aliki‐Eleni Farmaki , et al. · 2018

EXCEED is a longitudinal population-based cohort which facilitates investigation of genetic, environmental and lifestyle-related determinants of a broad range of diseases and of multiple morbidity through data collected at baseline and via…

United Kingdom: Transfers of Genomic Data to Third Countries Open

Mark Taylor, Susan Wallace, Megan Prictor · 2018

In the United Kingdom (UK), transfer of genomic data to third countries is regulated by data protection legislation. This is a composite of domestic and European Union (EU) law, with EU law to be adopted as domestic law when Brexit takes p…

United Kingdom: transfers of genomic data to third countries Open

Mark Taylor, Susan Wallace, Megan Prictor · 2018

Are ‘pseudonymised’ data always personal data? Implications of the GDPR for administrative data research in the UK Open

Miranda Mourby, Elaine Mackey, Mark Elliot, Heather Gowans, Susan Wallace , et al. · 2018

Exploring the potential duty of care in clinical genomics under UK law Open

Colin Mitchell, M.C. Ploem, Victoria Chico, Elizabeth Ormondroyd, Alison Hall , et al. · 2017

Genome-wide sequencing technologies are beginning to be used in projects that have both clinical diagnostic and research components. The clinical application of this technology, which generates a huge amount of information of varying diagn…

A decision tool to guide the ethics review of a challenging breed of emerging genomic projects Open

Yann Joly, D So, Gladys Osien, Laura Crimi, Martin Bobrow , et al. · 2016

Family tree and ancestry inference: is there a need for a ‘generational’ consent? Open

Susan Wallace, Elli G. Gourna, Viktoriya L. Nikolova, Nuala A. Sheehan · 2015

Data Safe Havens in health research and healthcare Open

Paul R. Burton, Madeleine J. Murtagh, Andy Boyd, James Williams, Edward S. Dove , et al. · 2015

Motivation: The data that put the ‘evidence’ into ‘evidence-based medicine’ are central to developments in public health, primary and hospital care. A fundamental challenge is to site such data in repositories that can easily be accessed u…

Compare and contrast: a cross-national study across UK, USA and Greek experts regarding return of incidental findings from clinical sequencing Open

Elli G. Gourna, Natalie Armstrong, Susan Wallace · 2015

Respecting Autonomy Over Time: Policy and Empirical Evidence on Re‐Consent in Longitudinal Biomedical Research Open

Susan Wallace, Elli G. Gourna, Graeme Laurie, Osama Shoush, J. Timothy Wright · 2015

Re‐consent in research, the asking for a new consent if there is a change in protocol or to confirm the expectations of participants in case of change, is an under‐explored issue. There is little clarity as to what changes should trigger r…

“I don’t mind damaging my own body” A qualitative study of the factors that motivate smokers to quit Open

Jane Bethea, Barnaby Murtagh, Susan Wallace · 2015

Public health messages around the risks of smoking and approaches to quitting should continue to have an emphasis on the dangers that an individual's smoking has on the lives of the people around them. More work also needs to be done to ra…

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