S. Duke Han
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Low frequency BOLD oscillations, APOE4, and plasma pTau217 Open
Background: Intrinsic low frequency oscillations in BOLD signal (BOLD LFOs) are generally considered nuisance signal in connectivity analysis and discarded. However, recent evidence suggests BOLD LFOs may shed light on cerebrovascular dysf…
Evaluation of Eutrophication in Small Reservoirs in Northern Agricultural Areas of China Open
Small reservoirs have important functions, such as water resource guarantee, flood control and drought resistance, biological habitat and maintaining regional economic development. In order to better clarify the impact of agricultural acti…
Healthcare workers' views on the response to COVID-19 in long-term care hospitals in Korea: a mixed-method study Open
Introduction Long-term care hospitals (LTCHs) faced challenges beyond the scope of their previous practice in response to the pandemic. However, not much is known about LTCHs' responses and business continuity plans (BCPs) during the pande…
View article: 0264 The Impact of Reported Sleep Duration and Subjective Sleep Sufficiency on Anxiety, Depression, and Fatigue
0264 The Impact of Reported Sleep Duration and Subjective Sleep Sufficiency on Anxiety, Depression, and Fatigue Open
Introduction Short sleep duration is linked to increased psychiatric risks, yet the protective role of subjective sleep sufficiency in short sleepers remains unclear. This study examines how reported sleep duration and subjective sleep suf…
Narrative-Centered Emotional Reflection: Scaffolding Autonomous Emotional Literacy with AI Open
Reflexion is an AI-powered platform designed to enable structured emotional self-reflection at scale. By integrating real-time emotion detection, layered reflective prompting, and metaphorical storytelling generation, Reflexion empowers us…
Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer’s disease biomarkers Open
The apolipoprotein E ( APOE ) ε4 allele is the strongest genetic risk factor for Alzheimer’s disease (AD). ApoE is glycosylated with an O-linked Core-1 sialylated glycan at several sites, yet the impact and function of this glycosylation o…
Protocol for a multi-domain scoping review to identify measures of decision-making ability in an ageing population Open
Introduction Deficits in decision-making (DM) can lead to adverse outcomes across multiple domains such as financial management and medical care. By hindering such DM abilities, cognitive impairment (CI) often affects quality of life. Rout…
Cerebrospinal fluid apoe glycosylation associates with biomarkers of Alzheimer’s Disease pathology Open
Background The apolipoprotein E (ApoE) Ɛ4 allele is associated with a significant risk for both late‐onset Alzheimer’s Disease (AD) development and cerebral amyloidosis, but the degree to which cerebrospinal fluid (CSF) apoE glycosylation …
View article: Lower entorhinal cortex thickness is associated with greater temporal discounting in cognitively unimpaired older adults
Lower entorhinal cortex thickness is associated with greater temporal discounting in cognitively unimpaired older adults Open
Background Alzheimer’s disease (AD) neuropathology may impact brain regions involved in decision making. Because of this, changes in decision making (e.g., economic preferences) may be an early behavioral manifestation of preclinical AD. T…
Reactions of clinical neuropsychologists to the Alzheimer's Association workgroup's draft diagnostic and staging criteria for Alzheimer's disease Open
Background An Alzheimer's Association (AA) workgroup published criteria for the diagnosis and staging of Alzheimer's disease (AD). To date, there have not been empirical investigations of professionals’ opinions regarding the AA criteria f…
View article: Healthcare Resource Use and Cost Associated with Negative Symptoms of Schizophrenia
Healthcare Resource Use and Cost Associated with Negative Symptoms of Schizophrenia Open
Introduction Schizophrenia is a chronic neurodevelopmental disorder characterized by positive, negative, and cognitive symptoms. While current antipsychotic (AP) medications are generally effective in treating positive symptoms, they don’t…
View article: Lower entorhinal cortex thickness is associated with greater financial exploitation vulnerability in cognitively unimpaired older adults
Lower entorhinal cortex thickness is associated with greater financial exploitation vulnerability in cognitively unimpaired older adults Open
Research suggests that increased financial exploitation vulnerability due to declining decision making may be an early behavioral manifestation of brain changes occurring in preclinical Alzheimer’s disease. One of the earliest documented b…
Factors Associated With Healthcare and Financial Decision Making Among Older Black Adults Without Dementia Open
Clinicians may implement strategies to bolster cognition and improve health and financial literacy to facilitate optimal decision-making among older Black adults.
View article: Procrastination, depressive symptomatology, and loneliness in later life
Procrastination, depressive symptomatology, and loneliness in later life Open
While age was not directly associated with procrastination, increasing age was associated with a decreased likelihood of depressive symptomatology, which was in turn associated with an increased likelihood of procrastination. Such findings…
Ethical, legal, and policy challenges in field-based neuroimaging research using emerging portable MRI technologies: guidance for investigators and for oversight Open
Researchers are rapidly developing and deploying highly portable MRI technology to conduct field-based research. The new technology will widen access to include new investigators in remote and unconventional settings and will facilitate gr…
Conducting Research with Highly Portable MRI in Community Settings: A Practical Guide to Navigating Ethical Issues and ELSI Checklist Open
Highly portable and accessible MRI technology will allow researchers to conduct field-based MRI research in community settings. Previous guidance for researchers working with fixed MRI does not address the novel ethical, legal, and societa…
Portable Accessible MRI in Dementia Research: Ethical Considerations About Research Representation and Dementia-Friendly Technology Open
The introduction of portable MRI (pMRI) has the potential to directly impact dementia research and ultimately clinical care. In this paper, we explore two ethical challenges facing the introduction of pMRI in dementia research. The first i…
Blood pressure variability, central autonomic network dysfunction and cerebral small vessel disease in APOE4 carriers Open
Background Increased blood pressure variability (BPV) is a risk factor for cerebral small vessel disease (CSVD) and neurodegeneration, independent of age and average blood pressure, particularly in apolipoprotein E4 ( APOE4 ) carriers. How…