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View article: WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response
WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response Open
The WEE1 kinase negatively regulates CDK1/2 to control DNA replication and mitotic entry. Genetic factors that determine sensitivity to WEE1 inhibitors (WEE1i) are largely unknown. A genome-wide insertional mutagenesis screen revealed that…
View article: Promoter-proximal transcription–translation coupling controls early transcription in <i>Escherichia coli</i>
Promoter-proximal transcription–translation coupling controls early transcription in <i>Escherichia coli</i> Open
The functional coupling of transcription and translation contributes significantly to maintaining messenger RNA (mRNA) expression in bacterial cells. Premature transcription termination and fast mRNA decay are known to limit the expression…
View article: Direct Quantification of Protein–Protein Interactions in Living Bacterial Cells
Direct Quantification of Protein–Protein Interactions in Living Bacterial Cells Open
Quantitative measurement of protein–protein interactions (PPIs) within living cells is vital for understanding their cellular functions at the molecular level and for applications in synthetic biology, protein engineering, and drug discove…
View article: WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response
WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response Open
The WEE1 kinase negatively regulates CDK1/2 to control DNA replication and mitotic entry. Genetic factors that determine sensitivity to WEE1 inhibitors (WEE1i) are largely unknown. A genome-wide insertional mutagenesis screen revealed that…
View article: Analysis of Fluorescent Proteins for Observing Single Gene Locus in a Live and Fixed <i>Escherichia coli</i> Cell
Analysis of Fluorescent Proteins for Observing Single Gene Locus in a Live and Fixed <i>Escherichia coli</i> Cell Open
Fluorescent proteins (FPs) are essential tools for advanced microscopy techniques such as super-resolution imaging, single-particle tracking, and quantitative single-molecule counting. Various FPs fused to DNA-binding proteins have been us…
View article: Dissecting translation elongation dynamics through ultra-long tracking of single ribosomes
Dissecting translation elongation dynamics through ultra-long tracking of single ribosomes Open
mRNA translation by ribosomes is a highly dynamic and heterogeneous process. However, current approaches cannot readily resolve individual ribosomes during translation, limiting our understanding of translation dynamics. Here, we develop a…
View article: Ribosome cooperativity promotes fast and efficient translation
Ribosome cooperativity promotes fast and efficient translation Open
The genetic information stored in mRNA is decoded by ribosomes during mRNA translation. mRNAs are typically translated by multiple ribosomes simultaneously, but it is unclear if different ribosomes translating the same mRNA functionally in…
View article: Co-transcriptional translation amplifies mRNA noise in<i>Escherichia coli</i>
Co-transcriptional translation amplifies mRNA noise in<i>Escherichia coli</i> Open
The variability in mRNA expression among isogenic cells exposed to identical environments is inherent. This variability originates from the inherent stochasticity of all processes underlying transcription. Although transcription and transl…
View article: Zero-Mode Waveguide Nanowells for Single-Molecule Detection in Living Cells
Zero-Mode Waveguide Nanowells for Single-Molecule Detection in Living Cells Open
Single-molecule fluorescence imaging experiments generally require sub-nanomolar protein concentrations to isolate single protein molecules, which makes such experiments challenging in live cells due to high intracellular protein concentra…
View article: Zero-mode waveguide nanowells for single-molecule detection in living cells
Zero-mode waveguide nanowells for single-molecule detection in living cells Open
Single-molecule fluorescence imaging experiments generally require sub-nanomolar protein concentrations to isolate single protein molecules, which makes such experiments challenging in live cells due to high intracellular protein concentra…
View article: Datasets underlying the paper Zero-mode waveguide nanowells for single-molecule detection in living cells
Datasets underlying the paper Zero-mode waveguide nanowells for single-molecule detection in living cells Open
Different datasets underlying the paper Zero-mode waveguide nanowells for single-molecule detection in living cells. The repository contains .zip archives, mostly containing a readme file with additional information. Cell imaging experimen…
View article: Datasets underlying the paper Zero-mode waveguide nanowells for single-molecule detection in living cells
Datasets underlying the paper Zero-mode waveguide nanowells for single-molecule detection in living cells Open
Different datasets underlying the paper Zero-mode waveguide nanowells for single-molecule detection in living cells. The repository contains .zip archives, mostly containing a readme file with additional information. Cell imaging experimen…
View article: Third-wave psychotherapy for caregivers of cancer patients: a scoping review
Third-wave psychotherapy for caregivers of cancer patients: a scoping review Open
Background Cancer caregivers provide extensive support in all aspects of patients' daily lives. It has been reported that a significant proportion of cancer caregivers experience emotional distress. As one way to solve this problem, third-…