Handrean Soran
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View article: Statin therapy and neuropathy in type 1 diabetes: A cross‐sectional study
Statin therapy and neuropathy in type 1 diabetes: A cross‐sectional study Open
Aims Dyslipidaemia contributes to the pathogenesis of diabetic peripheral neuropathy (DPN). While statins improve cardiovascular outcomes in diabetes, their potential neurotoxic effects remain debated. This study examined the impact of sta…
View article: Cross-Sectional analysis of demographic and clinical characteristics of patients in the United States using icosapent ethyl
Cross-Sectional analysis of demographic and clinical characteristics of patients in the United States using icosapent ethyl Open
Introduction Icosapent ethyl (IPE) is indicated for the treatment of severe hypertriglyceridemia (triglycerides ≥500 mg/dl) and for reducing the risk of cardiovascular (CV) events in statin-treated adults with moderately elevated triglycer…
View article: Cardiovascular disease morbidity is associated with social deprivation in subjects with familial hypercholesterolaemia (FH): A retrospective cohort study of individuals with FH in UK primary care and the UK Simon Broome register, linked with national hospital records
Cardiovascular disease morbidity is associated with social deprivation in subjects with familial hypercholesterolaemia (FH): A retrospective cohort study of individuals with FH in UK primary care and the UK Simon Broome register, linked with national hospital records Open
Strikingly fewer individuals with FH are identified from lower socioeconomic groups, though the most deprived FH patients have the highest risk of CVD and mortality. In CPRD, this risk was largely explained by smoking and alcohol consumpti…
View article: Greater corneal nerve loss at the inferior whorl in obesity
Greater corneal nerve loss at the inferior whorl in obesity Open
Background: Diabetic neuropathy is a dying-back neuropathy with evidence of greater distal corneal nerve loss at the inferior whorl. Individuals with obesity exhibit neuropathy and central corneal nerve loss. We have assessed whether there…
View article: Comparison of product label vs real-world safety data from branded icosapent ethyl users: A select analysis utilizing MarketScan data
Comparison of product label vs real-world safety data from branded icosapent ethyl users: A select analysis utilizing MarketScan data Open
IPE may be well tolerated in real-world settings.
View article: Rare variant genetic landscape of familial chylomicronemia syndrome (FCS) in the United Kingdom
Rare variant genetic landscape of familial chylomicronemia syndrome (FCS) in the United Kingdom Open
The genetic architecture of FCS in the United Kingdom is complex, with a substantial proportion affected by non-LPL FCS-causing genes. It also displays a significant regional and ethnic variations.
View article: 6503 A Randomized, Placebo-Controlled Phase 3 Study of Olezarsen In Patients With Familial Chylomicronemia Syndrome: The Balance Trial
6503 A Randomized, Placebo-Controlled Phase 3 Study of Olezarsen In Patients With Familial Chylomicronemia Syndrome: The Balance Trial Open
Disclosure: E.S. Stroes: Advisory Board Member; Self; Amgen Inc, Sanofi, Novartis Pharmaceuticals, AstraZeneca, Novo Nordisk, Ionis Pharmaceuticals Inc., Merck, Daiichi Sankyo. Grant Recipient; Self; Ionis Pharmaceuticals Inc., Novo Nordis…
View article: Ethnic Diversity and Distinctive Features of Familial Versus Multifactorial Chylomicronemia Syndrome: Insights From the UK FCS National Registry
Ethnic Diversity and Distinctive Features of Familial Versus Multifactorial Chylomicronemia Syndrome: Insights From the UK FCS National Registry Open
BACKGROUND: Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder. This study aimed to study the genotype distribution of FCS-causing genes in the United Kingdom, genotype-phenotype correlation, and clinical differ…
View article: Diabesity and microvascular disease: the impact of weight loss
Diabesity and microvascular disease: the impact of weight loss Open
There is increasing evidence that obesity is an independent risk factor for the development of microvascular disease. Addressing modifiable risk factors such as obesity may help prevent and even reverse microvascular complications, includi…
View article: Paraoxonase 1: evolution of the enzyme and of its role in protecting against atherosclerosis
Paraoxonase 1: evolution of the enzyme and of its role in protecting against atherosclerosis Open
Purpose of review To review the discoveries which led to the concept that serum paraoxonase 1 (PON1) is inversely related to atherosclerotic cardiovascular disease (ASCVD) incidence, how this association came to be regarded as causal and h…
View article: Sex Differences in Diagnosis, Treatment, and Cardiovascular Outcomes in Homozygous Familial Hypercholesterolemia
Sex Differences in Diagnosis, Treatment, and Cardiovascular Outcomes in Homozygous Familial Hypercholesterolemia Open
Importance Homozygous familial hypercholesterolemia (HoFH) is a rare genetic condition characterized by extremely increased low-density lipoprotein (LDL) cholesterol levels and premature atherosclerotic cardiovascular disease (ASCVD). Hete…
View article: Impact of Bariatric Surgery on Subtilisin/Kexin Type 9 (PCSK9) Gene Expression and Inflammation in the Adipose Tissue of Obese Diabetic Rats
Impact of Bariatric Surgery on Subtilisin/Kexin Type 9 (PCSK9) Gene Expression and Inflammation in the Adipose Tissue of Obese Diabetic Rats Open
Bariatric surgery improves dyslipidaemia and reduces body weight, but it remains unclear how bariatric surgery modulates gene expression in fat cells to influence the proprotein convertase subtilisin/kexin type 9 (PCSK-9) and low-density l…