Sorin Alexandrescu
YOU?
Author Swipe
View article: Cytoreductive Surgery in Ovarian Cancer: Should the New Optimal Threshold Be 2.5 mm?
Cytoreductive Surgery in Ovarian Cancer: Should the New Optimal Threshold Be 2.5 mm? Open
Background/Objectives: In patients with peritoneal metastases from ovarian cancer, current clinical guidelines recommend “optimal cytoreductive surgery (CRS)”, defined as leaving no residual tumor nodules greater than 1 cm in diameter. Of …
View article: Multimodal Prehabilitation in Major Abdominal Surgery—Rationale, Modalities, Results and Limitations
Multimodal Prehabilitation in Major Abdominal Surgery—Rationale, Modalities, Results and Limitations Open
Recent evidence revealed that an adequate preoperative physiological reserve is crucial to overcome surgical stress response. Consequently, a new concept, called prehabilitation, emerged, aiming to improve the preoperative functional reser…
View article: Lynch Syndrome—Impact of the Type of Deficient Mismatch Repair Gene Mutation on Diagnosis, Clinical Presentation, Surveillance and Therapeutic Approaches
Lynch Syndrome—Impact of the Type of Deficient Mismatch Repair Gene Mutation on Diagnosis, Clinical Presentation, Surveillance and Therapeutic Approaches Open
In today’s world, with its continuing advancements in genetics, the identification of Lynch syndrome (LS) increasingly relies on sophisticated genetic testing techniques. Most guidelines recommend a tailored surveillance program, as well a…
View article: Diagnostic Challenges and Multimodal Treatment in Primary Peritoneal Cancer: a Case Report
Diagnostic Challenges and Multimodal Treatment in Primary Peritoneal Cancer: a Case Report Open
Peritoneal cancer (PPC), a rare and aggressive malignancy, can develop from the peritoneal lining or as a secondary peritoneal cancer caused by metastases from neighbouring organs such as the ovaries, gastrointestinal tract, or breast. Ear…
View article: Preoperative identification of early extrahepatic recurrence after hepatectomy for colorectal liver metastases: A machine learning approach
Preoperative identification of early extrahepatic recurrence after hepatectomy for colorectal liver metastases: A machine learning approach Open
Background Machine learning (ML) may provide novel insights into data patterns and improve model prediction accuracy. The current study sought to develop and validate an ML model to predict early extra‐hepatic recurrence (EEHR) among patie…
View article: Development and Validation of a Predictive Risk Score for Blood Transfusion in Patients Undergoing Curative‐Intent Surgery for Intrahepatic Cholangiocarcinoma
Development and Validation of a Predictive Risk Score for Blood Transfusion in Patients Undergoing Curative‐Intent Surgery for Intrahepatic Cholangiocarcinoma Open
Background and Objectives Among patients undergoing liver resection for intrahepatic cholangiocarcinoma (ICC), perioperative bleeding requiring blood transfusion is a common complication, yet preoperative identification of patients at risk…
View article: Preoperative platelet count as an independent predictor of long‐term outcomes among patients undergoing resection for intrahepatic cholangiocarcinoma
Preoperative platelet count as an independent predictor of long‐term outcomes among patients undergoing resection for intrahepatic cholangiocarcinoma Open
Background and Objectives An elevated platelet count may reflect neoplastic and inflammatory states, with cytokine‐driven overproduction of platelets. The objective of this study was to evaluate the prognostic utility of high platelet coun…
View article: Bevacizumab Treatment for Metastatic Colorectal Cancer in Real-World Clinical Practice
Bevacizumab Treatment for Metastatic Colorectal Cancer in Real-World Clinical Practice Open
Background and Objectives: Colorectal cancer (CRC) is a leading cause of cancer-related mortality and morbidity worldwide. Bevacizumab was approved for the treatment of metastatic colorectal cancer (mCRC) based on favorable benefit-risk as…
View article: Surgical Options for Peritoneal Surface Metastases from Digestive Malignancies—A Comprehensive Review
Surgical Options for Peritoneal Surface Metastases from Digestive Malignancies—A Comprehensive Review Open
The peritoneum is a common site for the dissemination of digestive malignancies, particularly gastric, colorectal, appendix, or pancreatic cancer. Other tumors such as cholangiocarcinomas, digestive neuroendocrine tumors, or gastrointestin…
View article: Safety and Efficacy of Simultaneous Resection of Gastric Carcinoma and Synchronous Liver Metastasis—A Western Center Experience
Safety and Efficacy of Simultaneous Resection of Gastric Carcinoma and Synchronous Liver Metastasis—A Western Center Experience Open
Background and objectives: Gastric cancer (GC) is often diagnosed in the metastatic stage. Palliative systemic therapy is still considered the gold standard, even for patients with resectable oligometastatic disease. The aim of the current…
View article: TAC score better predicts survival than the BCLC following resection of hepatocellular carcinoma
TAC score better predicts survival than the BCLC following resection of hepatocellular carcinoma Open
Background Heterogeneity in hepatocellular carcinoma (HCC) still exists within the Barcelona clinic liver cancer (BCLC) subcategories. We developed a simple model to better discriminate and predict prognosis following resection. Methods Pa…
View article: A Novel Online Calculator to Predict Risk of Microvascular Invasion in the Preoperative Setting for Hepatocellular Carcinoma Patients Undergoing Curative-Intent Surgery
A Novel Online Calculator to Predict Risk of Microvascular Invasion in the Preoperative Setting for Hepatocellular Carcinoma Patients Undergoing Curative-Intent Surgery Open
Preoperative assessment of MVI using the online tool demonstrated very good accuracy to predict MVI.
View article: The Impact of Postoperative Complications on Survival after Simultaneous Resection of Colorectal Cancer and Liver Metastases
The Impact of Postoperative Complications on Survival after Simultaneous Resection of Colorectal Cancer and Liver Metastases Open
Background: The aim of this study was to investigate the impact of postoperative complications on the long-term outcomes of patients who had undergone simultaneous resection (SR) of colorectal cancer and synchronous liver metastases (SCLMs…
View article: Embryologic Origin of the Primary Tumor and RAS Status Predict Survival after Resection of Colorectal Liver Metastases
Embryologic Origin of the Primary Tumor and RAS Status Predict Survival after Resection of Colorectal Liver Metastases Open
Background and objectives. In colorectal cancers, the embryologic origin of the primary tumor determines important molecular dissimilarities between right-sided (RS) and left-sided (LS) carcinomas. Although important prognostic differences…
View article: Using the win ratio to compare laparoscopic versus open liver resection for colorectal cancer liver metastases
Using the win ratio to compare laparoscopic versus open liver resection for colorectal cancer liver metastases Open
Patients undergoing laparoscopic hepatectomy had 77% increased odds of "winning". Laparoscopic liver resection should be strongly considered as a preferred approach to resection in CRLM patients.
View article: Comparison of Hepatic Arterial Infusion Pump Chemotherapy vs Resection for Patients With Multifocal Intrahepatic Cholangiocarcinoma
Comparison of Hepatic Arterial Infusion Pump Chemotherapy vs Resection for Patients With Multifocal Intrahepatic Cholangiocarcinoma Open
This cohort study found that patients with multifocal iCCA had similar OS after HAIP floxuridine chemotherapy vs resection. Resection of multifocal intrahepatic cholangiocarcinoma needs to be considered carefully given the complication rat…
View article: Combined Positive Score for Programmed Death Ligand-1 Expression and Inflammatory Microenvironment in Gastrointestinal Stromal Tumors
Combined Positive Score for Programmed Death Ligand-1 Expression and Inflammatory Microenvironment in Gastrointestinal Stromal Tumors Open
Background and Objectives: GISTs are the most frequent type of mesenchymal neoplasm of the digestive tract. The prognosis is mainly determined by tumor dimensions, mitotic rate and location, but other less well-documented factors can influ…
View article: Assessment of clinical and pathological complete response after neoadjuvant chemoradiotherapy in rectal adenocarcinoma and its therapeutic implications
Assessment of clinical and pathological complete response after neoadjuvant chemoradiotherapy in rectal adenocarcinoma and its therapeutic implications Open
Because almost one fourth of patients with rectal adenocarcinoma (RC) achieve pathological complete response (pCR) after neoadjuvant chemoradiation therapy (CRT), having significantly higher survival rates than those without pCR, the asses…