Explanipedia

The Emerging Role of LncRNAs in T-Cell Plasticity in Breast Cancer Open

Aastha Dagar, Sandeep Singh, Vivek Uttam, Hridayesh Prakash, Aklank Jain · 2025

Despite advances in breast cancer treatment, the number of lives lost each year remains high. One of the significant challenges in treating breast cancer is the highly complex and dynamic tumor microenvironment (TME), which often makes tum…

Response of organic nutrient management in bottle gourd [Lagenaria siceraria (Mol) Standl.] Open

Sandeep Singh, Om Prakash Regar, Bhagwan Suman, Brijesh Kumar Meena, Champa Lal Regar · 2025

AI-Enabled Medical Chatbots: Advancements in Patient Query Handling and Automated Healthcare Delivery Open

Sandeep Singh, Tripti Rathee, Nipun Singhal · 2025

Artificial Intelligence (AI) is revolutionizing healthcare through the application of sophisticated Large Language Models (LLMs), facilitating rapid symptom assessment and enhanced disease identification. This study investigates the perfor…

A real world evaluation of an innovative artificial intelligence tool for population-level breast cancer screening Open

Karthik Adapa, Ashu Gupta, Sandeep Singh, Harmanpreet Kaur, Anjan Trikha , et al. · 2025

In resource-constrained countries like India, mammography-based breast screening is challenging to implement. This state-wide study, funded by the Government of Punjab, evaluated the use of Thermalytix, a low-cost, radiation-free AI tool, …

Customer Retention Modeling over the OTT Platform using Machine Learning Open

Upma Singh, Sandeep Singh, Tripti Rathee, Manav Vaish · 2024

Objectives: Customer retention, a multifaceted issue that plagues the digital entertainment industry, particularly within the realm of Over-the-Top (OTT) platforms, poses a significant challenge, impacting revenue and sustainability. With …

Quantitative insights from breast cancer screening of 100,000 women in India using an artificial intelligence-based tool Open

Siva Teja Kakileti, Geetha Manjunath, Sathiakar Collison, Himanshu Madhu, Sudhakar Sampangi , et al. · 2024

Background Breast cancer is the leading cause of cancer-related deaths among women. Early detection is crucial for improving treatment outcomes and reducing costs. Systematic screening programs using mammography pose significant challenges…

Scalability Challenges in Blockchain Networks: A Comparative Analysis Open

Dr.Pankaj Gupta, Prof.Vikas Singhal, Dr.Ajay Kumar Sahu, Sandeep Singh · 2024

Blockchain technology, originating with Nakamoto's seminal whitepaper in 2008, has evolved into a transformative force, promising decentralized, transparent, and secure digital transactions. However, the burgeoning impact of blockchain is …

Isolation, synthesis and medicinal chemistry of biphenyl analogs – A review Open

Sandeep Singh, P Geetha, R. Ramajayam · 2023

The scaffold-based drug design has been widely used in new drug discovery. Biphenyl and its analog scaffold are found in many drugs and naturally occurring compounds. To date an array of synthetic methodologies have been introduced to acce…

Scientific Approaches for Mass Production, Cold Storage and Release of Trichogramma: Their Role in Insect Pest Management Open

Heenashree Mansion, Anita Yadav, Ashutosh Singh Aman, Rishabh Mishra, Pankaj Kumar Rajpoot , et al. · 2023

The use of Trichogramma as a tool in the scientific management of pest insects emerges as a vital element to promote sustainability in agriculture. Having suitable storage methods for parasitoids is a valuable asset within biological contr…

Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder Open

Sandeep Singh, Alexander Botvinnik, Orr Shahar, Gilly Wolf, Corel Yakobi , et al. · 2023

Perfusion index as predictor of intraoperative hypotension following subarachnoid block in cesarean section: A prospective, observational study Open

Richa Jain, Sandeep Singh, Gurpreeti Kaur, Neeru Luthra, Namrata Sharma , et al. · 2023

Background: Perfusion index (PI) can be used to assess peripheral perfusion dynamics as it depicts the changes in peripheral vascular tone. Increased risk of fall in blood pressure following subarachnoid block (SAB) has been reported in pr…

Editorial: Biological aspects of targeted drug discovery: Development of novel targets and/or chemotherapies, and drug repurposing Open

Rajkumar Singh Kalra, Sandeep Singh, Anjana Munshi, Jitender Bariwal · 2022

EDITORIAL article Front. Oncol., 22 December 2022Sec. Pharmacology of Anti-Cancer Drugs Volume 12 - 2022 | https://doi.org/10.3389/fonc.2022.1106610

Genomic Variation Affecting MPV and PLT count in association with development of Ischemic Stroke and its Subtypes Open

Abhilash Ludhiadch, Sulena Sulena, Sandeep Singh, Sudip Chakraborty, Dixit Sharma , et al. · 2022

Background Platelets play a significant role in pathophysiology of ischemic stroke since they are involved in the formation of intravascular thrombus after erosion or rupture of the atherosclerotic plaques. Platelet (PLT) count and Mean pl…

In Vivo Anticancer Evaluation of 6b, a Non-Covalent Imidazo[1,2-a]quinoxaline-Based Epidermal Growth Factor Receptor Inhibitor against Human Xenograft Tumor in Nude Mice Open

Zahid Rafiq Bhat, Manvendra Kumar, Nisha Sharma, Umesh Prasad Yadav, Tashvinder Singh , et al. · 2022

Tyrosine kinase inhibitors are validated therapeutic agents against EGFR-mutated non-small cell lung cancer (NSCLC). However, the associated critical side effects of these agents are inevitable, demanding more specific and efficient target…

Natural Compound-Based Nanoparticles to Target Free Radicals in Cancer Open

Umesh Prasad Yadav, M. Rhuthuparna, Kanika Vasudev, Prabhat Suman, Anjana Munshi , et al. · 2022

Cell proliferation and malignant transformation are enabled by genetic and epigenetic changes. During the malignancy process, malignant cells acquire distinguishing characteristics. Cancer cells have acquired the ability to generate more r…

Natural Compound-Based Nanoparticles to Target Free Radicals in Cancer Open

Umesh Prasad Yadav, M. Rhuthuparna, Kanika Vasudeva, Prabhat Suman, Anjana Munshi , et al. · 2022

Cell proliferation and malignant transformation are enabled by genetic and epigenetic changes. During the malignancy process, malignant cells acquire distinguishing characteristics. Cancer cells have acquired the ability to generate more r…

N-Acetylcysteine Reverses Monocrotophos Exposure-Induced Hepatic Oxidative Damage via Mitigating Apoptosis, Inflammation and Structural Changes in Rats Open

Jagjeet Singh, Annu Phogat, Chandra Prakāsh, Sunil Kumar Chhikara, Sandeep Singh , et al. · 2021

Oxidative stress-mediated tissue damage is primarily involved in hepatic injuries and dysfunctioning. Natural antioxidants have been shown to exert hepatoprotective, anti-inflammatory and antiapoptotic properties. The present study evaluat…

SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes Open

Yogita Chhichholiya, Aman Kumar Suryan, Prabhat Suman, Anjana Munshi, Sandeep Singh · 2021

miRNAs are fascinating molecular players for gene regulation as individual miRNA can control multiple targets and a single target can be regulated by multiple miRNAs. Loss of miRNA regulated gene expression is often reported to be implicat…

Kinetics of Paracetamol oxidation by N-Chlorosaccharin in aqueous Acetic Acid Medium Open

S. N. Sinha, Sandeep Singh, Santosh Bahadur Singh · 2021

This paper contains the results of oxidation rate of paracetamol by Nchlorosaccharin (NCSA) in aqueous acetic acid medium that exhibits a first-order dependence on [NCSA] and one to zero-order each on [Paracetamol] and [acid].A positive so…

Let-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4 Open

Praveen Sharma, Vibhuti Sharma, Tarunveer S. Ahluwalia, Nilambra Dogra, Santosh Kumar , et al. · 2021

Background and objectives MicroRNA (miRNA) that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNA (mitomiR). Albeit mitomiRs have been shown to modulate gene expression, their functional impact within m…

Ulcerogenic Activity in Pyrazolopyrimidine Derivatives in Lab and It’s in Silico Toxicity: An Update on Novel Research Open

Sandeep Singh, Mohammad Gousuddin · 2021

Toxicity is a measure of any unfavourable or negative impact of substances. Toxicity endpoints, such as carcinogenicity or genotoxicity, are certain sorts of unfavourable effects that can be quantitative (e.g., LD50: deadly dosage to 50% o…

Reflections on Punjabi communities, COVID-19, and mental health Open

Sandeep Singh · 2021

A Bibliometric Analysis and Visualisation of Research Trends in Cobalt-Based Orthopaedic Implants Open

Sandeep Singh · 2021

Cobalt is one of the widely used metal for orthopaedic implants. The bibliometric analysis had been conducted to understand the active authors, organizations, journals, and countries involved in the research domain of “Cobalt-based orthopa…

Design and Synthesis of Non-Covalent Imidazo[1,2-a]quinoxaline-Based Inhibitors of EGFR and Their Anti-Cancer Assessment Open

Manvendra Kumar, Gaurav Joshi, Sahil Arora, Tashvinder Singh, Sajal Biswas , et al. · 2021

A series of 30 non-covalent imidazo[1,2-a]quinoxaline-based inhibitors of epidermal growth factor receptor (EGFR) were designed and synthesized. EGFR inhibitory assessment (against wild type) data of compounds revealed 6b, 7h, 7j, 9a and 9…

A Note on The Occurrence of Cerambycid Coptops Aedificator (F.) on Mango in Punjab Open

Sandeep Singh, Kolla Sreedevi, P. V. Rami Reddy · 2021

Correction to: Regulation of GAD65 expression by SMAR1 and p53 upon Streptozotocin treatment Open

Sandeep Singh, Varshiesh Raina, Pavithra L. Chavali, Taronish D. Dubash, Kadreppa Sreenath , et al. · 2020

An amendment to this paper has been published and can be accessed via the original article.

Metabolic Adaptations in Cancer Stem Cells Open

Umesh Prasad Yadav, Tashvinder Singh, Pramit Kumar, Praveen Sharma, Harsimrat Kaur , et al. · 2020

Cancer stem cells (CSCs) are a small and elusive subpopulation of self-renewing cancer cells with remarkable ability to initiate, propagate, and spread the malignant disease. In addition, they exhibit increased resistance to anticancer the…

In vitro and in vivo effects of flubendiamide and copper on cyto-genotoxicity, oxidative stress and spleen histology of rats and its modulation by resveratrol, catechin, curcumin and α-tocopherol Open

Rajesh Mandil, Atul Prakash, Anu Rahal, Sandeep Singh, Deepak Sharma , et al. · 2020

Design and Synthesis of New Tubulin Polymerization Inhibitors Inspired from Combretastatin A-4 Open

Akanksha Sharma, Umesh Prasad Yadav, Sandeep Singh, Harish Holla · 2020

This poster presents the synthesis of a series of tubulin polymerization inhibitor molecules, inspired by combretastatin A-4 (CA-4). CA-4 is a potent anticancer compound targeting tubulin polymerisation, however, poor pharmacokinetic profi…

Anticancer potential of some imidazole and fused imidazole derivatives: exploring the mechanism <i>via</i> epidermal growth factor receptor (EGFR) inhibition Open

Sourav Kalra, Gaurav Joshi, Manvendra Kumar, Sahil Arora, Harsimrat Kaur , et al. · 2020

Imidazole-based epidermal growth factor receptor (EGFR) inhibitors were computationally designed and synthesized.

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