Souradeep Basu
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View article: Control of CDK activity and the cell cycle by CKS proteins
Control of CDK activity and the cell cycle by CKS proteins Open
The eukaryotic cell cycle is orchestrated by the activity of Cyclin-Dependent Kinases (CDKs) 1 . Although most mechanisms controlling CDK activity are well understood, one class of proteins - the CDK regulatory subunit (CKS) proteins - rem…
View article: AlphaGenome: advancing regulatory variant effect prediction with a unified DNA sequence model
AlphaGenome: advancing regulatory variant effect prediction with a unified DNA sequence model Open
Deep learning models that predict functional genomic measurements from DNA sequence are powerful tools for deciphering the genetic regulatory code. Existing methods trade off between input sequence length and prediction resolution, thereby…
View article: CDK activity at the centrosome regulates the cell cycle
CDK activity at the centrosome regulates the cell cycle Open
View article: CDK activity at the centrosome regulates the cell cycle
CDK activity at the centrosome regulates the cell cycle Open
Cyclin-dependent kinases (CDKs) complexed with cyclins drive progression through the eukaryotic cell cycle. From yeast to human cells, cyclin-CDK localises to the centrosome, but the importance of this localisation is unclear. The conserve…
View article: A CDK activity buffer ensures mitotic completion
A CDK activity buffer ensures mitotic completion Open
The eukaryotic cell cycle is driven by the activity of cyclin-dependent kinases (CDKs). CDK activity rises over 50-fold during the cell cycle, from a low level in G1 to a high level in mitosis. However, it is not known whether the entire r…
View article: Core control principles of the eukaryotic cell cycle
Core control principles of the eukaryotic cell cycle Open
Cyclin-dependent kinases (CDKs) lie at the heart of eukaryotic cell cycle control, with different cyclin–CDK complexes initiating DNA replication (S-CDKs) and mitosis (M-CDKs) 1,2 . However, the principles on which cyclin–CDK complexes org…
View article: Core Control Principles of the Eukaryotic Cell Cycle
Core Control Principles of the Eukaryotic Cell Cycle Open
Cyclin dependent kinases (CDKs) lie at the heart of eukaryotic cell cycle control, with different Cyclin-CDK complexes initiating DNA replication (S-CDKs) and mitosis (M-CDKs). However, the principles on which Cyclin-CDKs organise the temp…
View article: Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease Open
SARS-CoV-2 is a coronavirus that emerged in 2019 and rapidly spread across the world causing a deadly pandemic with tremendous social and economic costs. Healthcare systems worldwide are under great pressure, and there is an urgent need fo…
View article: Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase Open
The COVID-19 pandemic has presented itself as one of the most critical public health challenges of the century, with SARS-CoV-2 being the third member of the Coronaviridae family to cause a fatal disease in humans. There is currently only …
View article: CDK control pathways integrate cell size and ploidy information to control cell division
CDK control pathways integrate cell size and ploidy information to control cell division Open
Maintenance of cell size homeostasis is a property that is conserved throughout eukaryotes. Cell size homeostasis is brought about by the co-ordination of cell division with cell growth and requires restriction of smaller cells from underg…
View article: Author response: CDK control pathways integrate cell size and ploidy information to control cell division
Author response: CDK control pathways integrate cell size and ploidy information to control cell division Open
View article: Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp14/nsp10 Exoribonuclease
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp14/nsp10 Exoribonuclease Open
Summary SARS-CoV-2 is a coronavirus that emerged in 2019 and rapidly spread across the world causing a deadly pandemic with tremendous social and economic costs. Healthcare systems worldwide are under great pressure, and there is urgent ne…
View article: Identification of SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of the nsp14 RNA Cap Methyltransferase
Identification of SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of the nsp14 RNA Cap Methyltransferase Open
Summary The COVID-19 pandemic has presented itself as one of the most critical public health challenges of the century, with SARS-CoV-2 being the third member of the Coronaviridae family to cause fatal disease in humans. There is currently…
View article: Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy
Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy Open
View article: Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center
Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center Open
View article: Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Open
View article: Scalable and robust SARS-CoV-2 testing in an academic center
Scalable and robust SARS-CoV-2 testing in an academic center Open
View article: The Hydrophobic Patch Directs Cyclin B to Centrosomes to Promote Global CDK Phosphorylation at Mitosis
The Hydrophobic Patch Directs Cyclin B to Centrosomes to Promote Global CDK Phosphorylation at Mitosis Open
View article: Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint
Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint Open
Significance A dedicated endoplasmic reticulum quality control (ERQC) machinery ensures the correct fold of secreted proteins bearing N-linked glycans, which constitute around a fifth of the whole proteome and are essential for many import…
View article: Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals
Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals Open
Significance Most pathogenic enveloped viruses crucially depend on the quality control (QC) machinery in the endoplasmic reticulum (ER) of the host cell. ERQC inhibitors therefore have the double potential benefit of targeting a wide varie…