Sanjay Singh
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View article: EXTH-33. The oncolytic adenovirus RGDOX sensitizes the anti-tumor efficacy of immune checkpoint blockades in murine melanoma brain metastases models
EXTH-33. The oncolytic adenovirus RGDOX sensitizes the anti-tumor efficacy of immune checkpoint blockades in murine melanoma brain metastases models Open
Amongst solid cancers, melanoma brain metastases (MBM) have the highest likelihood of metastasizing to the brain. The use of immune checkpoint inhibitors (ICI) for metastatic melanoma has emerged as first line therapy; however, intracrania…
View article: Low‐Valent Group 14 Species Supported by BICAAC: Isolation of a Germylone and a Digermanium Compound
Low‐Valent Group 14 Species Supported by BICAAC: Isolation of a Germylone and a Digermanium Compound Open
Herein, we have disclosed the successful isolation and spectroscopic characterization of a series of bicyclic (alkyl)(amino) carbene ( Me/iPr BICAAC) complexes of GeCl 2 and SnX 2 ; [ Me BICAAC‐GeCl 2 ( 1 ); iPr BICAAC‐GeCl 2 ( 2 ); Me BIC…
View article: Interaction Of Imatinib With 2ghw(Sars-Cov2 Spike) Protein Structure: A Molecular Docking Study
Interaction Of Imatinib With 2ghw(Sars-Cov2 Spike) Protein Structure: A Molecular Docking Study Open
View article: Mitigating oxidative stress in red blood cells with quercetin-loaded liposomes: a promising strategy
Mitigating oxidative stress in red blood cells with quercetin-loaded liposomes: a promising strategy Open
Quercetin-loaded liposomes effectively protect red blood cells from oxidative stress during the aging process, enhancing antioxidant defence and offering a promising therapeutic strategy.
View article: Nature-Inspired Nano Cellulose Materials, Advancements in Nano Cellulose Preparation and Versatile Applications
Nature-Inspired Nano Cellulose Materials, Advancements in Nano Cellulose Preparation and Versatile Applications Open
A promising ecofriendly, cost-effective biomaterial derived from natural sources, i.e., lignocellulose natural fibers from trees, plants, agri waste, fruits, vegetables, seeds, and leaves. It clicked the attention of the researchers due to…
View article: Use of antioxidant nanoliposomes for co-delivery of PTEN plasmids and plumbagin to induce apoptosis in hepatic cancer cells
Use of antioxidant nanoliposomes for co-delivery of PTEN plasmids and plumbagin to induce apoptosis in hepatic cancer cells Open
Hepatocellular carcinoma remains a challenging contributor to the global cancer and related mortality, and claims approximately 800,000 deaths each year. Dysregulation or loss of function mutations involving the tumor suppressor gene, phos…
View article: Triethyl phosphine decorated cerium oxide nanoparticles exhibit selective killing of the unicellular protozoan parasite Leishmania donovani
Triethyl phosphine decorated cerium oxide nanoparticles exhibit selective killing of the unicellular protozoan parasite Leishmania donovani Open
View article: Nanomaterials in Animal Nutrition and Disease Treatment: Recent Developments and Future Aspects
Nanomaterials in Animal Nutrition and Disease Treatment: Recent Developments and Future Aspects Open
Raise in the human population requires increased demand for animal-derived food products. The quality of animal-derived food depends on the livestock's health and nutrition levels. Globally, every possible effort to make livestock disease …
View article: Low expression of TMPRSS2–a SARS-CoV-2 internalization protease–associates with basal subtype of head and neck squamous cell carcinoma
Low expression of TMPRSS2–a SARS-CoV-2 internalization protease–associates with basal subtype of head and neck squamous cell carcinoma Open
SARS-CoV-2 is a single-stranded RNA virus that has caused the ongoing COVID-19 pandemic. ACE2 and other genes utilized by SARS-CoV-2 to enter human cells have been shown to express in Head and Neck Squamous Cell Carcinoma (HNSCC) pa…
View article: Identification of 1,2,4-Oxadiazoles-Based Novel EGFR Inhibitors: Molecular Dynamics Simulation-Guided Identification and in vitro ADME Studies
Identification of 1,2,4-Oxadiazoles-Based Novel EGFR Inhibitors: Molecular Dynamics Simulation-Guided Identification and in vitro ADME Studies Open
Overall, in-vitro ADME results of these molecules showed good drug-like properties, which are well correlated with the in-silico ADME data, making them ideal for developing an oral drug delivery formulation.
View article: CuO Nanoparticles as Copper-Ion Reservoirs for Elesclomol-Mediated Intracellular Oxidative Stress: Implications for Anticancer Therapies
CuO Nanoparticles as Copper-Ion Reservoirs for Elesclomol-Mediated Intracellular Oxidative Stress: Implications for Anticancer Therapies Open
Dissolution of metal/metal oxide nanoparticles has been widely exploited to be one of the mechanisms of inducing oxidative stress within bacterial and mammalian cells. Elesclomol has been already evaluated in clinical trials, and the repor…
View article: Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry
Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry Open
Immune-related therapies have revolutionized the management of cancer. Oncolytic viruses are now considered part of the immunotherapy armamentarium and have shown promise in clinical trials of patients with glioblastoma. These studies have…
View article: Translational Development of A Tumor Junction Opening Technology
Translational Development of A Tumor Junction Opening Technology Open
Our goal is to overcome treatment resistance in ovarian cancer patients, which occurs in most cases after an initial positive response to chemotherapy. A central resistance mechanism is the maintenance of desmoglein-2 (DSG2)-positive tight…
View article: Calcium carbonate nano- and microparticles: synthesis methods and biological applications
Calcium carbonate nano- and microparticles: synthesis methods and biological applications Open
View article: Second wave of the Covid-19 pandemic in Delhi, India: high seroprevalence not a deterrent?
Second wave of the Covid-19 pandemic in Delhi, India: high seroprevalence not a deterrent? Open
Background We report the findings of a large follow-up community-based serosurvey and correlating it with the COVID-19 test-positivity rate and the case load observed during the peak of the second wave of the Covid-19 pandemic in Delhi, In…
View article: Redox Active Cerium Oxide Nanoparticles: Current Status and Burning Issues
Redox Active Cerium Oxide Nanoparticles: Current Status and Burning Issues Open
Research on cerium oxide nanoparticles (nanoceria) has captivated the scientific community due to their unique physical and chemical properties, such as redox activity and oxygen buffering capacity, which made them available for many techn…
View article: Transformation in band energetics of CuO nanoparticles as a function of solubility and its impact on cellular response
Transformation in band energetics of CuO nanoparticles as a function of solubility and its impact on cellular response Open
View article: Polymer-Coated Cerium Oxide Nanoparticles as Oxidoreductase-like Catalysts
Polymer-Coated Cerium Oxide Nanoparticles as Oxidoreductase-like Catalysts Open
Cerium oxide nanoparticles have been shown to mimic oxidoreductase enzymes by catalyzing the decomposition of organic substrates and reactive oxygen species. This mimicry can be found in superoxide radicals and hydrogen peroxides, which ar…
View article: Dextran-Coated Cerium Oxide Nanoparticles: A Computed Tomography Contrast Agent for Imaging the Gastrointestinal Tract and Inflammatory Bowel Disease
Dextran-Coated Cerium Oxide Nanoparticles: A Computed Tomography Contrast Agent for Imaging the Gastrointestinal Tract and Inflammatory Bowel Disease Open
Computed tomography (CT) is an X-ray-based medical imaging technique commonly used for noninvasive gastrointestinal tract (GIT) imaging. Iodine- and barium-based CT contrast agents are used in the clinic for GIT imaging; however, inflammat…
View article: Oxidative stress-mediated genotoxic effect of zinc oxide nanoparticles on Deinococcus radiodurans
Oxidative stress-mediated genotoxic effect of zinc oxide nanoparticles on Deinococcus radiodurans Open
View article: DNA Methylation Mediated Cell-Cell Communication in BovinePreimplantation Embryos
DNA Methylation Mediated Cell-Cell Communication in BovinePreimplantation Embryos Open
View article: Emerging Trends in Nanotechnology: Nanozymes, Imaging Probes and Biosensors and Nanocarriers
Emerging Trends in Nanotechnology: Nanozymes, Imaging Probes and Biosensors and Nanocarriers Open
View article: Nanomaterials Exhibiting Enzyme-Like Properties (Nanozymes): Current Advances and Future Perspectives
Nanomaterials Exhibiting Enzyme-Like Properties (Nanozymes): Current Advances and Future Perspectives Open
Biological enzymes are macromolecular catalysts that catalyze the biochemical reactions of the natural systems. Although each enzyme performs a particular function, however, holds several drawbacks, which limits its utilization in broad-sp…
View article: Unveiling the effect of 11-MUA coating on biocompatibility and catalytic activity of a gold-core cerium oxide-shell-based nanozyme
Unveiling the effect of 11-MUA coating on biocompatibility and catalytic activity of a gold-core cerium oxide-shell-based nanozyme Open
Replacement of CTAB and CeO2 nanoparticle layer by 11-MUA from the surface of Au core-CeO2 shell nanoparticle.
View article: Biomimetic polycaprolactone-chitosan nanofibrous substrate influenced cell cycle and ECM secretion affect cellular uptake of nanoclusters
Biomimetic polycaprolactone-chitosan nanofibrous substrate influenced cell cycle and ECM secretion affect cellular uptake of nanoclusters Open
Biomimetic cell culture substrates are developed as an alternative to the conventional substrates. They provide necessary biochemical and biophysical cues to the cells from their surrounding environment for their optimal growth, behaviour …
View article: Recent advances and future prospects of iron oxide nanoparticles in biomedicine and diagnostics
Recent advances and future prospects of iron oxide nanoparticles in biomedicine and diagnostics Open
View article: Liposomal formulation of vitamin A for the potential treatment of osteoporosis
Liposomal formulation of vitamin A for the potential treatment of osteoporosis Open
Vitamin A targeting to bones is a suitable treatment for osteoporosis. In this study, we have developed vitamin A-encapsulated liposomes that can be useful to deliver vitamin A to the bones in a selective manner. This liposomal formulation…
View article: Liposome encapsulation of doxorubicin and celecoxib in combination inhibits progression of human skin cancer cells
Liposome encapsulation of doxorubicin and celecoxib in combination inhibits progression of human skin cancer cells Open
Therapeutic agents aimed at inhibiting a single molecular target have not been successful in cancer therapy, but rather they impart resistance. However, multi-target inhibitors have shown promising results in circumventing the development …
View article: Curcumin Ag nanoconjugates for improved therapeutic effects in cancer
Curcumin Ag nanoconjugates for improved therapeutic effects in cancer Open
Curcumin has a broad spectrum of pharmacological activities, one of them is anticancer activity that is mediated through multiple mechanisms. The major disadvantage associated with the use of curcumin is its low bioavailability due to its …
View article: Cellular internalization and antioxidant activity of cerium oxide nanoparticles in human monocytic leukemia cells
Cellular internalization and antioxidant activity of cerium oxide nanoparticles in human monocytic leukemia cells Open
Overproduction of free radicals contributes to oxidative stress and inflammation leading to various disease conditions. Cerium oxide nanoparticles (nanoceria) have been shown to scavenge free radicals and have the potential for being used …