Ernest Han
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View article: Correction: Senguttuvan et al. The Anti-Cancer Role of Pterostilbene in Endometrial Cancer: A Phase II Prospective, Randomized, Window-of-Opportunity Clinical Trial with Megestrol Acetate. Antioxidants 2025, 14, 345
Correction: Senguttuvan et al. The Anti-Cancer Role of Pterostilbene in Endometrial Cancer: A Phase II Prospective, Randomized, Window-of-Opportunity Clinical Trial with Megestrol Acetate. Antioxidants 2025, 14, 345 Open
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View article: The Anti-Cancer Role of Pterostilbene in Endometrial Cancer: A Phase II Prospective, Randomized, Window-of-Opportunity Clinical Trial with Megestrol Acetate
The Anti-Cancer Role of Pterostilbene in Endometrial Cancer: A Phase II Prospective, Randomized, Window-of-Opportunity Clinical Trial with Megestrol Acetate Open
Pterostilbene (3,5-dimethoxy-40-hydroxystilbene) is a potent oral antioxidant with a promising role in anti-cancer treatment. In endometrial cancer (EC), in vitro studies demonstrated a synergistic antiproliferative effect of pterostilbene…
View article: PR043/#416 Restaging uterine cancer patients with the 2023 FIGO guidelines: clinical characteristics and survival differences
PR043/#416 Restaging uterine cancer patients with the 2023 FIGO guidelines: clinical characteristics and survival differences Open
Introduction The landscape of endometrial cancer (EC) classification is undergoing a dramatic transformation as the disease moves towards molecularly driven categorization. Four molecular subtypes have been shown to portend different progn…
View article: EP017/#738 Insights from ovarian cancer patients’ rapid autopsy shed light on mechanisms of CD4+ T cell-mediated pre-metastatic niche formation through the STAT3 axis
EP017/#738 Insights from ovarian cancer patients’ rapid autopsy shed light on mechanisms of CD4+ T cell-mediated pre-metastatic niche formation through the STAT3 axis Open
Introduction Whether adaptive immune cells are required for the formation of pre-metastatic niches critical for tumor metastasis remains unknown. Prior research indicates that Signal transducer and activator of transcription 3 (STAT3) cont…
View article: EP124/#764 Natural compound baicalein synergizes with AMP-activated protein kinase activator SR04 in endometrial cancer by inhibition of PI3K/MTOR and STAT3 without activating AKT or MAPK
EP124/#764 Natural compound baicalein synergizes with AMP-activated protein kinase activator SR04 in endometrial cancer by inhibition of PI3K/MTOR and STAT3 without activating AKT or MAPK Open
Introduction Loss of PTEN expression is common in endometrial cancer. The PI3K/mTOR pathway has been a target, but counter-regulatory pathways via Akt and ERK may hinder efficacy. We previously showed that the natural flavonoid baicalein i…
View article: Impact of Sodium Thiosulfate on Prevention of Nephrotoxicities in HIPEC: An Ancillary Evaluation of Cisplatin-Induced Toxicities in Ovarian Cancer
Impact of Sodium Thiosulfate on Prevention of Nephrotoxicities in HIPEC: An Ancillary Evaluation of Cisplatin-Induced Toxicities in Ovarian Cancer Open
Purpose Hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin confers a survival benefit in epithelial ovarian cancer (EOC) but is associated with renal toxicity. Sodium thiosulfate (ST) is used for nephroprotection for HIPEC wi…
View article: BRCA germline mutations in multiethnic gynecologic patients: A 10-year retrospective analysis from a single cancer institute
BRCA germline mutations in multiethnic gynecologic patients: A 10-year retrospective analysis from a single cancer institute Open
Histologic and genetic mutation information from racially and ethnically diverse populations is warranted to better inform future cancer predisposition and promote health equity. A single institutional, retrospective capture of patients wi…
View article: Genomic Analyses of Germline and Somatic Variation in High-Grade Serous Ovarian Cancer
Genomic Analyses of Germline and Somatic Variation in High-Grade Serous Ovarian Cancer Open
Background High-grade serous ovarian cancers (HGSCs) display a high degree of complex genetic alterations. In this study, we identified germline and somatic genetic alterations in HGSC and their association with relapse-free and overall su…
View article: Additional file 2 of Genomic analyses of germline and somatic variation in high-grade serous ovarian cancer
Additional file 2 of Genomic analyses of germline and somatic variation in high-grade serous ovarian cancer Open
Additional file 2.
View article: EP266/#300 Robotic-assisted laparoscopic ovarian cancer staging is associated with higher nodal yield in early-stage ovarian cancer: a national cancer database study
EP266/#300 Robotic-assisted laparoscopic ovarian cancer staging is associated with higher nodal yield in early-stage ovarian cancer: a national cancer database study Open
Objectives Compare nodal yield by minimally-invasive surgical approach in early-stage (I-II) ovarian cancer. Methods The National Cancer Database (NCDB) was queried for patients with early stage (I-II) ovarian cancer between 2004 and 2017 …
View article: EP267/#1048 Preclinical evaluation of a novel near infrared fluorescent anti-TAG72-IR800 monoclonal antibody for identification of ovarian cancer in a mouse model
EP267/#1048 Preclinical evaluation of a novel near infrared fluorescent anti-TAG72-IR800 monoclonal antibody for identification of ovarian cancer in a mouse model Open
Objectives Determine whether ovarian cancer cells can be detected using, a novel monoclonal antibody (mAB) to TAG72 conjugated to a near infrared (NIR) dye (anti-TAG72-IR800) in a preclinical mouse model. Methods Athymic mice were subcutan…
View article: Hyperthermic Intraperitoneal Chemotherapy–Induced Molecular Changes in Humans Validate Preclinical Data in Ovarian Cancer
Hyperthermic Intraperitoneal Chemotherapy–Induced Molecular Changes in Humans Validate Preclinical Data in Ovarian Cancer Open
PURPOSE Hyperthermic intraperitoneal chemotherapy (HIPEC) confers a survival benefit in epithelial ovarian cancer (EOC) and in preclinical models. However, the molecular changes induced by HIPEC have not been corroborated in humans. PATIEN…
View article: NCCN Guidelines® Insights: Uterine Neoplasms, Version 3.2021
NCCN Guidelines® Insights: Uterine Neoplasms, Version 3.2021 Open
The NCCN Guidelines for Uterine Neoplasms provide recommendations for diagnostic workup, clinical staging, and treatment options for patients with endometrial cancer or uterine sarcoma. These NCCN Guidelines Insights focus on the recent ad…
View article: Allogeneic human neural stem cells for improved therapeutic delivery to peritoneal ovarian cancer
Allogeneic human neural stem cells for improved therapeutic delivery to peritoneal ovarian cancer Open
Background Immortalized, clonal HB1.F3.CD 21 human neural stem/progenitor cells (NSCs), loaded with therapeutic cargo prior to intraperitoneal (IP) injection, have been shown to improve the delivery and efficacy of therapeutic agents in pr…
View article: Allogeneic Human Neural Stem Cells for Improved Therapeutic Delivery to Peritoneal Ovarian Cancer
Allogeneic Human Neural Stem Cells for Improved Therapeutic Delivery to Peritoneal Ovarian Cancer Open
Background: Immortalized, clonal HB1.F3.CD21 human neural stem/progenitor cells (NSCs), loaded with therapeutic cargo prior to intraperitoneal (IP) injection, have been shown to improve the delivery and efficacy of therapeutic agents in pr…
View article: Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer
Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer Open
The evolution of resistance in high-grade serous ovarian cancer (HGSOC) cells following chemotherapy is only partially understood. To uncover phenotypic changes associated with chemotherapy resistance, we profiled single-cell RNA-sequencin…
View article: 405 Impact of hyperthermic intraperitoneal chemotherapy (HIPEC) on tumor microenvironment (TME) in ovarian cancer – a subanalysis from a Phase I clinical trial
405 Impact of hyperthermic intraperitoneal chemotherapy (HIPEC) on tumor microenvironment (TME) in ovarian cancer – a subanalysis from a Phase I clinical trial Open
Background Immunogenic cell death has been suggested as a mechanism for HIPEC, through the release of heat shock proteins, and resulting in activation of tumor-specific T cells. Methods This is a subgroup analysis of a Phase I trial using …
View article: Synergistic Anti-Tumor Activity by Targeting Multiple Signaling Pathways in Ovarian Cancer
Synergistic Anti-Tumor Activity by Targeting Multiple Signaling Pathways in Ovarian Cancer Open
More effective therapy is needed to improve the survival of patients with advanced and recurrent ovarian cancer. Preclinical and early clinical studies with single molecular targeted agents have shown limited antitumor activity in ovarian …
View article: Frontline Management of Epithelial Ovarian Cancer—Combining Clinical Expertise with Community Practice Collaboration and Cutting-Edge Research
Frontline Management of Epithelial Ovarian Cancer—Combining Clinical Expertise with Community Practice Collaboration and Cutting-Edge Research Open
Epithelial ovarian cancer (EOC) is the most common histology of ovarian cancer defined as epithelial cancer derived from the ovaries, fallopian tubes, or primary peritoneum. It is the fifth most common cause of cancer-related death in wome…
View article: Allogeneic Human Neural Stem Cells for Improved Therapeutic Delivery to Peritoneal Ovarian Cancer.
Allogeneic Human Neural Stem Cells for Improved Therapeutic Delivery to Peritoneal Ovarian Cancer. Open
Background: Immortalized, clonal HB1.F3.CD21 human neural stem/progenitor cells (NSCs), loaded with therapeutic cargo prior to intraperitoneal (IP) injection, have been shown to improve the delivery and efficacy of therapeutic agents in pr…